1 Composition and mechanism of action of
This combination drug includes amoxicillin and clavulanic acid, an inhibitor of bacterial enzymes.
- Amoxicillin is an effective substance for eliminating bacteria, having a semi-synthetic origin. This drug acts on the protective wall of the microbe, reducing the release of protein. This leads to a slow development or the gradual withering away of the pathogenic bacteria.
- Clavulanic acid is necessary in order to destroy the microflora resistant to the main active substance. This component also increases the intracellular activity of leukocytes, increasing the overall effectiveness of the drug.
Microorganisms that produce β-lactamase type 1 do not enter the area of action of the drug. These include: serration, enterobacter, Pseudomonas aeruginosa, etc. Especially often these bacteria are found in chronic sinusitis, so before the treatment of this form of the disease, diagnostics is carried out to identify the type of harmful microflora.
Amoxiclav is available in the form of tablets, solutions for intravenous administration and suspensions. With internal application, the drug is rapidly absorbed into the digestive tract. Active substances quickly accumulate in the maxillary sinuses, middle ear and lungs. A small amount of the drug can get into breast milk, so when pregnant, it should be taken with caution.
We recommend that you familiarize yourself with
- Antritis preparations for adults
- Effective antibiotics for sinusitis
- Treatment of chronic maxillary sinusitis
- Contemporary preparations from Pressure!
2 Contraindications and side effects
When taking the drug, negative effects appear very rarely and quickly disappear. Nevertheless, one should keep in mind that the following unpleasant phenomena can occur from different organs and systems:
- Nervous system: sleep disturbance, headaches, increased irritability.
- Skin: rashes, swelling, swelling.
- GASTROINTESTINAL TRACT: symptoms of intoxication, in rare cases - pseudomembranous colitis.
- Circulatory system: thrombocytopenia, anemia, leukopenia, agranulocytosis.
- Liver: increased enzyme release, hepatitis, jaundice.
- Other systems: hematuria, candidiasis.
In addition to individual sensitivity to the components of the formulation, Amoxiclave is not recommended for use in such cases:
- if there is an anamnesis of jaundice or hepatitis;
- for mononucleosis caused by infection.
3 Course of admission and dosage
The dosage and duration of treatment is determined by the attending physician.
If the patient has allergic diseases, the treatment of sinusitis with Amoxiclav is accompanied by the intake of antihistamines.
In the presence of kidney pathologies, doctors usually reduce dosage.
The most effective medicine shows if you take it after eating. In addition, this method of administration will avoid side effects from the gastrointestinal tract.
Amoxiclav does not affect the motor skills of the hands, so it can be taken before driving. But it must be taken into account that this drug reduces the effectiveness of contraceptive means of internal application and can differently affect the effectiveness of concomitant medications. Therefore, combining Amoxiclav with other drugs can only be recommended by a doctor.
The drug is not compatible with alcohol. Alcoholic drinks reduce its effectiveness and increase the negative effect on the liver.