Today the herpes virus responds well to therapeutic effects with medications. But if the body is resistant to the components of these drugs, you need to find medications that can still overcome the ailment. And there is such a tool - it is a component of sodium foscarnet.
Features of the drug
Foscarnet sodium or Foscarnet sodium - a substance with a pronounced effect against herpes. It is used for treatment in the case when the body is resistant to other drugs, for example, to acyclovir.
The drug is sold at pharmacies without a prescription form.
Fosquavir( photo)
Dosage forms
Fosquavir is available in two forms:
- in the form of an external cream-ointment with 3% Foscarnet sodium;
- solutions for intravenous administration of 250 and 500 ml.
The tablet form of the drug does not exist, so that its availability when ingested through the digestive tract is extremely low.
Foscarnet Composition( Foscavir)
Foscarnet is a water-soluble powder, whose chemical name sounds like dihydroxyphosphine carboxylic acid oxide trisodium salt.
Price
The cost of packing Fosquavir, consisting of 10 bottles - 2400 euros.
Pharmacological action
Foscarnet or Fosquavir is an antiviral drug of high efficacy.
Pharmacodynamics
After ingestion, Foscarnet sodium suppresses the DNA of all herpes viruses:
- Varicela-Zoster;
- cytomegalovirus;
- is a simple virus.
Pharmacokinetics
Foscarnet sodium is excreted completely unchanged by the urinary system, which makes fosquavir toxic to the kidneys. The elimination of half of the dose Foscarnet takes 8 hours, and after 3-4 days is deduced by 95%. A small part of the substance remains in the bone tissue.
Indications
Fosquavir is indicated for use in:
- herpes I and II types;
- Cytomegalovirus;
- Type IV EB;
- hepatitis A and B;
- HIV.
There is also varicella among the indications, but in practice the foscarnet is not prescribed for the treatment of chickenpox, because the price of the medicine does not correspond to the therapeutic effect in the pathology that passes independently.
Instruction for use
- Foscarnet is poorly soluble in water, therefore before administration it is bred in isotonic glucose solution or plasma-substituting sodium chloride solution.
- The drug is effective only with intravenous administration, while the low rate of its accumulation in the bloodstream is important, so Fosquavir is not injected by injection, but by drip.
Adults
The dosage of the drug is calculated based on the weight of the person. With AIDS per kilogram of weight, 60 mg of Foscarnet sodium is needed. The drug is added dropwise after 8 hours. When the interval between infusions is 12 hours, the dose rises to 100-120 mg per kilogram of body weight. The average course is about 3 weeks.
For herpes, Foscavir is administered at a rate of 40 mg Foscarnet sodium per kilogram of body weight 3 times a day for 15-20 days.
For infants, infants
For newborns, prescribing is strictly prohibited.
The course of treatment for children older than 3 years is three days, during which time Fosquavir is administered at a dose of 50 mg of the drug per 1 kg of body weight three times a day. Then, until the end of the course, the length of which is determined by the attending physician, Foscavir is administered once a day at a dose of 30 mg per kilogram of weight.
In pregnancy and lactation,
Pregnant women and nursing mothers should not use preparations based on Foscarnet sodium.
Contraindications
A sodium foscarnet is not prescribed by the treating physician to a patient if a history of it is found:
- pregnancy;
- lactation period;
- is an allergy to the drug;
- CRF;
- age over 65 years.
The last contraindication is not categorical, and the drug can theoretically be administered to the elderly, but with sufficient care and under the supervision of a physician.
Side effects of
Given the fact that the substance of Fosquavir is excreted through the urinary system, nephrotoxicity is one of the main side effects. On the background of admission, the following signs of decreased renal filtration may appear:
- diuresis change in the background of the usual drinking regimen;
- change in color of urine;
- edema;
- nausea and vomiting.
During treatment, there must be control over the level of creatinine and urea. If these indicators become extremely high, hemodialysis can be indicated.
- Also, fosquavir has a negative effect on the nervous system. On the background of therapy, many patients complained of headache, emotional lability, depressive state, rapid fatigue and decreased cognitive functions.
- On the part of the hematopoietic system, anemia occurs - a decrease in hemoglobin, and thromboembolism - a high degree of coagulation. As a rule, studies conducted against a background of therapy quickly reveal this fact and prescribe medications to normalize the viscosity and composition of the blood.
- If the cream is locally applied with a component of Foscarnet sodium, a burning sensation and hyperemia of the skin may occur.
Special instructions
For the greatest effectiveness, it is necessary to begin herpes therapy before the bubble stage, then the drug quickly eliminates the virus and its external manifestations on the skin.
Interaction with other medicines and alcohol
Fosquavir should not be used together with analogues in the mechanism of action, for example, with Acyclovir. Also, do not concurrently prescribe Fosquavir and drugs from the groups:
- with aminoglycosides;
- amphotericin;
- with pentamidine.
Reviews
The drug has few reviews, because its use in herpes is indicated solely in the absence of the effect of acyclovir, which occurs infrequently. In addition, the drug has a high cost, which also affects its popularity among consumers.
But for the treatment of HIV infection, Fosquavir is one of the most effective means of having a lot of positive feedback from both doctors and patients.
Analogs of
The analogues of Fosquavir are:
- Gefin;
- Triapten;
- Acyclovir.
However, according to the therapeutic properties of Fosquavir is the most effective than all existing analogues.