Voltaren belongs to the group of drugs of anti-inflammatory action, not related to steroid preparations. A characteristic therapeutic effect is manifested in the elimination of pain, inflammation and heat. These properties allow us to classify Voltaren as an analgesic. The analgesic property of Voltaren is used for oral, topical and injectable dosage forms.
Voltaren eliminates pains of various genesis: articular, menstrual, head, dental. The pharmacological effect is directed not only to relief of pain, but also to reduction of swelling and inflammatory reactions. This article will tell you about analogues and prices for Voltaren gel, injections, candles, ointment, plaster, about its instructions for use and reviews about it by doctors and patients.
Features of the preparation
Composition Voltaren
The main active substance of all dosage forms of Voltaren is diclofenac sodium. The composition of the excipients will differ due to the consistency of the drug. Additional substances of tablets are dry colloidal silicon oxide, stearic magnesium, povidone K-30, maize starch, cellulose in microcrystals, starch derivative with a substituent group - sodium carboxymethyl, lactose monohydrate.
For the shaping and yellow color of the tablet, titanium and iron oxides, hypromellose, talc and glyceryl hydroxy stearic macrogol are used. Brownish tablets contain iron oxide in a more oxidized form. To better dissolve the tablet shell in the digestive system, silicone emulsion without foaming and polymers based on ethyl ester of acrylic acid are added.
Tablets and solution for intramuscular injection include from 25 mg to 100 mg of diclofenac sodium, depending on the weight of the tablet or the volume of the solution administered and the duration of action of the drug. The same amount of active substance is found in suppositories. The content of diclofenac sodium in gels - from 1 to 2%, in eye drops - 0.1%, in patches - from 15 to 30 mg. The spray has 8 mg of active substance, and the powder for dilution with subsequent oral administration is 50 mg.
Medicinal forms
Voltaren is represented by the largest number of dosage forms in modern pharmacy.
- Voltaren tablets can be bought from 240 to 295 rubles depending on the amount of active substance in them. The manufacturer of tablets is the Swiss company Novartis.
- The cheapest is plaster Voltaren , the price for which does not exceed 170 rubles. A patch, fixed on the skin for 24 hours and the amount of active substance is 2 times greater than in a conventional Voltaren, costs more - 250 rubles per package.
- Gel Voltaren is characterized by the percentage of active substance and the mass of tuba, which affects the cost of the drug. A gel with a capacity of 20 grams and a concentration of 1% costs 205 rubles, and a 50 g tube of the same concentration costs 360 rubles.50 grams of Voltaren gel 2% concentration can be bought for 445 rubles.100 g tuba 1% concentration is more expensive than all dosage forms - 450 rubles.
- Voltaren's spray for 114 doses of 8 mg in one dose is determined at a price of 380 rubles.
- The cost of rectal candles differs depending on the number of pieces in the package. Candles amounting to 5 pieces per pack will cost 300 rubles. Packing with 10 candles costs about 350 rubles.
- The solution for intramuscular injection of Voltaren is determined by the initial price of 285 rubles. The package contains 5 ampoules of Voltaren 3 ml each. Taking
As a non-steroidal anti-inflammatory drug, Voltaren reduces the intensity of pain, inflammatory reactions and high fever.
Pharmacodynamics
The cause of development of inflammatory processes is an increase in the concentration of prostaglandins formed in tissue structures.
- Diclofenac sodium reduces the cellular synthesis of prostaglandins, thereby reducing the manifestation of symptoms of inflammation. The use of diclofenac sodium does not affect the formation of cartilaginous cells of proteoglycans.
- Voltaren provides relief of symptoms in rheumatic complications. Puffiness of the joints and pain in the kinetic state are reduced, as well as at rest. Normalized biochemical indicators of blood.
- Often, Voltaren is used after surgery, as the process of edema formation in the area of a surgical wound is reduced, the pain sensations are arrested, the postoperative inflammatory process in the tissues is inhibited.
- The drug facilitates the process of menstruation, not allowing abundant blood and eliminating soreness. The use of Voltaren is not limited to rheumatic pains, and in different dosage forms. A more rapid effect is observed with intramuscular administration of the drug( 1 to 15 minutes).
Pharmacokinetics
Oral administration of Voltaren provides a rapid effect of the drug due to a high rate of absorption, depending on the presence of a shell dissolving in the intestine. The rapidity of this drug is in direct proportion to the amount of active substance in Voltaren.
- The maximum concentration of diclofenac sodium in the blood plasma is detected 2 hours after taking Voltaren. Simultaneous food intake together with the drug does not affect the concentration of active substance in the blood plasma, but reduces the speed of absorption of the drug.
- About 50% of the absorbed sodium diclofenac is split in the liver to intermediate metabolic products, which have less physiological activity. The rate of hepatic metabolism is different at rectal and oral administration at a lower rate than when injected.
- Recollection of Voltaren does not change the rate of its cleavage, the time of action of the active substance. The amount of diclofenac sodium contained in the blood is dependent on the dose taken.
- 0.3% of diclofenac sodium is in the blood in a free state, the rest is associated with a plasma albumen - albumin. In the joint bag, diclofenac sodium enters after 3 hours after entering the bloodstream. After the active substance enters the synovial fluid, its concentration in the blood decreases, while in the synovial fluid it remains unchanged for half a day.
- The half-life of diclofenac sodium and its 4 intermediate derivatives is 1-2 hours. All 5 compounds have good physiological activity. The sixth compound, an intermediate with a substituted hydroxo group and a methoxy radical, has a pronounced weak physiological effect and has a half-life of 8 hours.
- Excretion of diclofenac sodium is carried out by the digestive system by ingesting the products of the active substance together with bile. One-hundredth part of diclofenac is not subject to disintegration and is excreted through the bile duct into the duodenum intact.
Indications
Voltaren shows:
- with pain from the spine and nerves emerging from it( sciatica, lumbago, neuralgia, etc.);
- inflammatory processes and destruction of bone( cartilaginous tissues) in joints and bones( arthritis, spondyloarthritis, tendovaginitis, etc.);
- postoperative pain and the effects of tissue trauma;
- inflammation in the pelvic organs;
- as an additional agent in the treatment of inflammation of the throat, middle ear, tonsils;
- with osteochondrosis( including cervical) and even dizziness with it;
- for infectious myocarditis;
- in complex therapy for pulmonary sarcoidosis;
- for the treatment of prostate adenoma in men;
- permanent and regular pain in women during menstruation.
Sometimes Voltaren is also used for stomach cancer, bullous dermatitis.
Instructions for use
The nature of treatment with Voltaren does not differ in the duration of the course and is expressed in the individual selection of the minimum dosage required to relieve symptoms. It is recommended to use tablet forms on an empty stomach, after taking a small amount of water.
Voltaren can be taken several times a day, dividing the daily dose. The maximum dose for an adult is 100-150 mg, although in medical practice it is enough to eliminate symptoms of 50-75 mg. Children older than one year receive no more than 2 mg per 1 kg of body weight. In the period of breastfeeding and the second half of pregnancy, Voltaren is undesirable.
Contraindications
Voltaren should not be used with:
- gastric ulcer, bleeding and perforations;
- acute period of inflammation of the intestine;
- urticaria, rhinitis caused by taking aspirin;
- severe degree of renal, hepatic and cardiac failure;
- hepatic pathologies in the acute period;
- increased susceptibility to bleeding;
- when performing cardiac bypass surgery;
- marked lack of potassium concentration in the blood;
- individual intolerance to the active and additional substances of the drug.
Side effects of
On the part of almost all functional systems, disturbances can occur when taking Voltaren, if dosage is not met or there is an individual intolerance to the drug.
Special instructions
- Before the appointment of a drug, a thorough examination of the medical history, history and other diagnostic procedures is recommended for a complete picture of the patient's health.
- Voriconazole and Sulfinpyrazole, in collaboration with Voltaren, have bilateral systemic oppression. The rest of the drugs are not critical from simultaneous reception.
Reviews
Patients who took Voltaren for a short while, respond positively to the drug as an analgesic. Long-term use in most responding users of the drug caused stomach pain.
For cheap and expensive analogues of Voltaren read below.
Analogues
Each dosage form has a number of Voltaren analogues:
- Diklovit,
- Arthrosan,
- Diclof, etc.
Even more useful information about Voltaren is contained in this video: