Mometasone: indications and contraindications, instructions for use, reviews and analogues

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Drugs that are glucocorticosteroids, with local application successfully solve the problems associated with skin diseases( various dermatitis).However, when using them, care must be taken in connection with the possibility of side effects.

Features of the drug

The drug, which contains glucocorticosteroid ingredients, can affect the hypothalamic-pituitary-adrenal system. This is because the glucocorticoid is a synthetic analogue of the substance that this system produces in the body.

After stopping the use of the drug, the function of the adrenal gland is restored. Due to the very low digestibility of the ingredients in the preparation, the risk of getting them into the circulatory system of the patient is small. The rules for use should be observed, namely, do not use the product if the surface of the mucous layer or skin is damaged.

Dosage forms

Manufacturers produce the drug for external use in the form of:

• cream,
• ointment,
• lotion.

The drug is also used for inhalation of nasal passages, and for this purpose there is a dosage form in the form of a nasal spray.

Composition of Mometasone

The main active substance is mometasone. Cream contains additional substances:

• macrogol,
• glyceryl monostearate,
• wax white,
• acid phosphoric,
• hexylenglycol,
• cetostearyl ether,
• cetostearyl alcohol,
• paraffin white,
• purified water,
• titanium dioxide.

Ointment, in the form of additional ingredients, includes

• hexylene glycol,
• propylene glycol monopalmitostearate,
• paraffin white,
• wax white,
• phosphoric acid,
• purified water.

Price

The average cost of the drug in the pharmacy chain:

• cream( 5 g) - 98 rubles.,
• ointment( 5 g) - 98 rubles.,
• lotion( 20 ml) - 580 rub.,
• spray( 18 doses)

The drug is endowed with the ability to cause in the body such effects:

• vasoconstrictive action,
• antiallergic protection,
• anti-inflammatory effect,
• antipruritic effect.

Pharmacodynamics

The mechanism of action of mometasone is based on the fact that the reactions that are initiated in cells by the active substance reduce the possibility of the inflammatory process. In addition, allergic reactions get inhibited at any stage of development.

Pharmacokinetics

Studies have shown that the components of the drug do not accumulate in the body. The presence of the drug substance in the skin, eight hours after the application of the agent, was 0.4% of the dose. The agent was applied to the skin in the form of an application, the bandage was not carried out.

When the drug enters the body by the nasal route, it was found that its bioavailability is 0.1% of the applied dose and even less. The presence of the substance was determined eight hours after the application of the agent( in the circulatory system).

Indications

The specialist prescribes mometasone for treatment if the patient has such problems:

• seborrheic dermatitis,
• stasis-dermatitis,
• eczema,
• contact dermatitis,
• solar dermatitis,
• intertriginous dermatitis,
• atopic dermatitis,
• exfoliative dermatitis,
• neurodermatitis,
• psoriasis,
• radiation dermatitis,
• anogenital pruritus,
• healthy scalp(fibrous part),
• senile pruritus,
• pollinosis of the nose,
• allergic rhinitis.

Instruction for use

• The preparation, in the form of ointment or cream , is used externally for the treatment of dermatitis. On the affected surface, apply a thin layer. The procedure is carried out once a day.
• Lotion is used for the improvement of the scalp. The remedy is applied by the method: the liquid is applied to the skin, while simultaneously rubbing gently until the liquid is completely absorbed.
• nasal spray is used for inhalation in the nasal passages. To do this, use a special nozzle. One release of the substance after pressing the button on the vial is approximately 100 μg. But before using the bottle, you need to make seven strokes in a row so that after that the suspension is applied the next time you press it.

Adult

• The use of a cream, ointment or lotion to treat affected areas of the skin has the same recommendations for children and adults. Nasal spray is administered to different age categories with the appropriate dose.
• For patients of adult age and children after 12 years of age, the use of nasal spray is recommended with a daily dose of 200 μg. Inhalation is carried out twice a day using for the procedure 50 μg of the suspension in each nostril.
• If there is no desired effect, then the daily dose of the substance used is increased to 400 μg. In this case, and increase the number of procedures from two to four. If there are signs of improvement in well-being, the dose should be reduced.

For children

In childhood, nasal spray is recommended to apply once a day for 50 μg in each nostril. The daily dose for inhalation in the nasal passages is 100 μg. The age at which specialists allow the use of a nasal inhalation agent is 2 years.

Children's age is more susceptible to possible side effects of the drug, so its use should be done under the close supervision of a specialist.

In pregnancy and lactation

The condition of bearing and breastfeeding is a reason for contraindications to the use of the drug. How dangerous or safe to be treated with mometasone, with the conditions mentioned earlier, there are not enough studies.

In each individual case, the decision to prescribe the remedy remains with the doctor. The principle on the basis of which the choice is made - the benefit of the application exceeds the possible harm from the drug.

Contraindications

Do not prescribe mometasone if the patient has such problems or circumstances:

• on the skin or mucous membrane there is a violation of integrity( due to illness, injury, surgery in recent times);
• children's period( up to two years),
• increased individual sensitivity to the ingredients of the drug,
• , the patient has an infection that has not been treated:
  • tuberculosis infection,
  • fungal infection of the skin,
  • herpes,
  • viral or bacterial infection.

Side effects of

When using the drug for the treatment of skin diseases, undesirable phenomena may appear:

• burning of the skin,
  • burning,
  • burning of the skin,
  • appearance of rosacea,
  • pruritus,
  • folliculitis,
  • allergic contact dermatitis,
  • dry skin with subsequent irritation,
  • acne,
  • secondary infection,
  • hypertrichosis,
  • hypopigmentation,
  • striae,
  • perioral dermatitis,
  • sweating.

  Special instructions

  • The use of occlusive dressings increases the side effects of the drug. Since hormonal drugs are able to create a reversible suppression of the vital activity of the hypothalamic-pituitary-adrenal system, it is necessary to apply the drug, not exceeding the recommended doses, and at the first signs of side effects to cancel it or reduce the dose.
  • The drug should not be applied to the face area, especially it is necessary to protect the eyes from getting the product on the mucous surface. In the field of inguinal and axillary folds, mometasone is also not used.
  • If a related infection has occurred, symptomatic treatment of this phenomenon is necessary, and the use of momezaton should be temporarily suspended.

  Interaction with other drugs

  The chemical properties of the ingredients suggest that the drug is incompatible with alkalis. Other unwanted interactions with drugs have not been described in the medical literature.

  Reviews

  Users note that the drug is very effective. Side effects are not common.

  Treatment with a drug of allergic dermatitis, with the application of daily application, showed a therapeutic result in three weeks.

  Analogs

  Similar tools:

  • Betnoveit,
  • Momat,
  • Medrol,
  • Alvesco.