Among medicines that have an exceptionally positive effect on the condition and work of the stomach, it is worthwhile dwelling on a drug with a wide spectrum of action, Cimetidine, which copes well with the manifestation of gastric ulcerative lesions. Its balanced composition and minimal amount of side effects during use make it possible to prescribe it even at the advanced stages of pathological processes on the gastric mucosa, stimulating the regenerative processes of damaged tissues, and also providing elimination of unpleasant manifestations of peptic ulcer.
Cimetidine is considered to be one of the popular antiulcer drugs, since the preservation of demand for it is determined both by a high degree of efficiency and by relatively low cost: when buying, the buyer refers specifically to the value indicator, evaluating the means and possibilities for application in each specific case by the responses and characteristics of the agent. The balance of the composition provides a rapid manifestation of the positive effect for a short time since the beginning of the medication, numerous positive reviews suggest the possibility of using cimetidine.
Features of the drug
Latin name of the drug Cimetidine, you can buy it at pharmacies only if you have a doctor's prescription. This drug can be used both in monotherapy and in complex treatment, which only increases the effectiveness of the treatment. The preservation of a positive result for a long time after the appointment of cimetidine is provided by its composition, as well as by the correctly selected dosage - it is for this reason that treatment with it should be performed only by the attending physician-gastroenterologist. Self-medication of any lesions of the stomach can cause the appearance of negative manifestations on the health of the patient, slow the receipt of a pronounced positive dynamics in treatment.
Ease of use of this tool also increases the level of interest to it from the buyers, and the cost, while being quite affordable in comparison with similar anti-ulcer agents, can also be considered one of the important advantages of the drug in question.
Dosage Forms
There are several different drug variants of cimetidine available on sale:
- tablets , which are coated with a soluble coating and arranged in a cellular blister for 10 pieces each;
- capsules , having an oblong shape and providing a simple swallowing;
- injection , recommended for use in cases of neglect of the pathological process and the presence of complications in the health of the patient.
Due to the presence of several dosage forms of the drug in question, it is possible to select the most convenient and more effective version of cimetidine. The doctor after the examination of the patient prescribes a certain type of medicine that can be used both independently and in complex treatment.
Composition of cimetidine
The active component of the drug is cimetidine, which has a calming and restoring effect on the gastric mucosa. Its high efficiency allows in a short time to eliminate the most obvious manifestations of peptic ulcer, stabilize the patient's condition and eliminate the most unpleasant symptoms of the disease.
The auxiliary components of the agent include the following substances:
- magnesium stearate;
- microcrystalline cellulose;
- Povidone;
- corn starch;
- talcum powder.
Balanced and well thought-out composition determines the possibility of obtaining positive dynamics from the treatment, with the minimal amount of possible negative manifestations during treatment with cimetidine, this should be considered an important advantage of the antiulcer medication in question.
Prices
The cost should be called one of the indicators, which primarily draws the buyer's attention. At different companies-sellers this tool is offered at a price of 108 to 1100 rubles. The cost also depends on the volume of the package and the dosage form of the product.
Pharmacological action
By acting on the process of gastric acid production of hydrochloric acid, cimetidine eliminates the unpleasant manifestations of its excessive production, normalizing the acidity index and ensuring the normal functioning of the digestive system. When using significant doses of the agent, the development of adverse manifestations from the gastrointestinal tract in the form of nausea, heartburn is likely.
Pharmacodynamics
At the onset of the drug, a significant activation of the active substance is noted, which blocks the action of the H2 receptors responsible for susceptibility to histamine. At the same time, the body's defenses are restored, and the mucous membrane is quickly restored in places where it is damaged.
With the appointment of this remedy, it is possible to increase the production of gastric mucus, which perfectly neutralizes the irritating effect of hydrochloric acid. This allows us to stabilize the digestion process rather quickly, eliminating the soreness typical of ulcerative diseases.
Pharmacokinetics
When the preparation is dissolved in the stomach, the H2-histamine receptors located in the walls of the blood vessels of the stomach are neutralized. It also has antiulcer results in treatment, which is important in advanced stages of the disease.
The distribution of the drug( its active substance) in the tissues and fluids of the body is uniform, the removal of the decay products is carried out by the kidneys.
Indications
For use, cimetidine is usually prescribed in the presence of the following pathological conditions or diseases of the gastrointestinal tract:
- with ulcerous lesions of the stomach and duodenum;
- with the advanced stage of gastritis;
- in the development of Zollinger-Ellison syndrome;
- with reflux-esophagitis.
This medication can also be used in the prophylactic treatment of ulcers on the mucous membrane of the stomach and other organs of the gastrointestinal tract. Also the drug is used in some cases of therapy of such ailments as dermographic, cold, aquatic, thermal, cholinergic urticaria, and Quincke's edema.
Instruction for use
The use of cimetidine is prescribed by the doctor in case of gastric lesions, and depending on the degree of neglect of the existing disease, as well as the patient's well-being, the dosage of this remedy and the duration of use are determined. The degree of therapeutic effect is determined individually, and it depends on the susceptibility of the patient's body.
- Capsules and tablets Cimetidine is taken 2-3 times daily before meals, washed down with a sufficient amount of water. The duration of the drug depends on the age of the patient. Single dosage can vary significantly from 100 to 800 mg per day.
- Intramuscular injection of ( injection solution) is performed with advanced stages of gastrointestinal diseases. The daily dose also depends on the patient's age and should not exceed 4.2 mg per day.
Adults
In the treatment of ulcerative lesions, adults are given capsules or tablets of the drug 2-3 times a day, the duration of taking them is 2-5 weeks. Further it is recommended to take a break, after which, if there is evidence, treatment can be continued. The process of taking cimetidine should be controlled at all stages by the attending physician.
Children, newborns
The drug is administered to children from 10-12 years of age. At a younger age, because of the increased sensitivity of the child's body, the probability of adverse side effects is great.
In pregnancy, lactation
During pregnancy and lactation, cimetidine can be used only if there is a pronounced positive dynamics and a positive result over a possible negative manifestation. This is explained by the possibility of penetration of the active substance through the placental barrier and into breast milk, which can cause a negative impact on the child's body.
Contraindications
Cimetidine should not be used if the patient has severe renal and hepatic insufficiency, as well as individual intolerance of the constituent components of the drug.
Side effects of
To the adverse manifestation of cimetidine, the following can be attributed:
- deterioration of the digestive tract;
- feeling of nausea;
- the urge to vomit;Heartburn and eructation
- ;
- is also likely to have negative manifestations on the part of the nervous system in the form of confusion, dizziness, increased drowsiness, or vice versa overexcitation.
There may be an arrhythmia, a bradycardia.
Special instructions
Due to possible negative effects on the nervous system of the active substance of the drug, caution should be exercised: it must be manifested when people are assigned Fencarol, whose activities are associated with working with particularly complex mechanisms, since the agent can cause deterioration of self-control.
Interaction with other medications
Cimetidine has a number of contraindications when combined with other medicines.
- Thus, its use is prohibited with the parallel use of analgesics, because the drug efficacy of the active substance cimetidine is significantly reduced.
- Also not recommended for joint use with antibacterial drugs, because in the opposite case there is a high probability of an increase in the content of constituents of the drugs in the plasma.
- Cimetidine reduces the rate of excretion and metabolism of terbinafine.
- With concomitant use with cimetidine, plasma loratadine concentrations increase.
- The use of lomustine in combined chemotherapy regimens along with the drug "Cimetidine" and cytostatic drugs can significantly increase the occurrence of thrombocytopenia and leukopenia.
- Cimetidine increases the level of drug concentration of Delagil and Hingamin in the blood.
- The pressure drop can increase with simultaneous reception with Corinfar.
- The action of Euphyllin is enhanced by cimetidine.
Reviews
Numerous reviews indicate a high degree of effectiveness of the drug Cimetidine in the treatment of ulcerative lesions of the stomach and digestive organs. The balance of the composition makes it possible to obtain high results in eliminating the unpleasant manifestations of such diseases.
Buyers note the availability of the cost of the facility in comparison with most of the modern counterparts.
Analogues
To drugs with antiulcer action should include Gastrosidin, Tsinamed, Tsimegeksal.