An effective drug for stopping the growth of malignant tumors in the early period of their development.
Form release, formulation and packaging
The product is available in ampoules( 15 mg).The package also contains ampoules with a sodium chloride solution, with a capacity of 20 ml each. The contents of additional ampoules are used for manipulation as a solvent.
The active substance is bleomycin.
Manufacturer
The medicine is manufactured in the country of Japan.
Indications for use
The drug is used in conjunction with other antitumor drugs. It can be combined with radiotherapy.
Assign in case of such health problems:
- Kidney cancer,
- Kaposi's sarcoma,
- testicular tumor,
- Penile oncology,
- Malignant ovarian formations,
- Skin cancer( squamous),
- Oncological disease of esophagus,
- Glioma,
- of the formation in the neck regionand head,
- pleural effusion,
- teratocarcinoma,
- reticulosarcoma,
- malignant cervical lesion.
Contraindications
The drug is not prescribed if the patient has a disease( or condition):
- in the lungs there is a process of increasing the presence of connective tissue( fibrosis),
- child bearing,
- respiratory function have severe disorders,
- kidney damage.
Pharmacological action
The antitumor effect is manifested in the fact that the DNA molecule responsible for the transmission of information by inheritance is subject to separation.
A special feature of the drug is its ability to accumulate in the cells of the skin and in the mucous membranes.
Therefore, the use of the drug for the treatment of formations on the skin, as well as on the mucous membranes, in the early stages, is effective.
The product suppresses natural defenses in a small amount. Bone marrow hemopoiesis also suffers to a small extent.
Instructions for use Bleomycin
The average dose that is recommended for taking during the course of treatment - per kilogram of weight 6 mg. The agent is administered intramuscularly or intravenously.
In manipulations, bleomycin is combined with a solution of sodium chloride, and also novocaine can be added for anesthesia. The preparation is administered at a slow speed.
Repeat the course at 2 months, but the dose should be reduced. When appointing a course of treatment for children, the doses are selected taking into account the weight of the child. For the elderly, they are cautious when determining the dose of the drug.
Side effects of
As the course of treatment of with bleomycin in , negative body reactions are possible:
- on the skin focal hyperkeratoses,
- vulvitis,
- body temperature may increase,
- hair loss( partial or complete),
- stomatitis,
- lack of appetite,
- tipsfingers become very sensitive,
- increased brittleness of the nails,
- deterioration of the lung:
- increase in the presence of connective tissue,
- pneumonia.
Disturbances caused by the use of medication, usually after the cessation of treatment. But the side effects in the lungs constitute a separate group.
The situation should be monitored, the lungs examined and, if impairment occurs, the drug is discontinued.
Overdose
If the dose is exceeded, then the reaction of the body is possible:
- rapid pulse,
- hypotension,
- fever
- symptoms of shock.
The effects of overdose are removed with the help of symptomatic treatment.
Special instructions
If the patient has varicella, use the drug with caution. The same applies to those cases when the patient was in contact with a person suffering from chicken pox.
In diseases caused by other herpes( shingles), as well as in acute conditions associated with manifestations of infection in the body, the drug is prescribed by the doctor taking into account these diseases of the patient.
Attentive treatment by a treating specialist is required by patients who have such characteristics or health problems:
- lung pathology,
- elderly patient's age,
- kidney disease,
- heart disease,
- patients who have been or are being exposed to radiation therapy.
Drug Interaction
When concomitantly taking the drug with cisplatinum, a delay in the release of the products of decay of bleomycin may occur. This may increase the toxic effect of the latter drug.
If the patient receives oxygen( this may be as part of anesthesia), a combination of bleomycin and an air toxicity reaction can be triggered.
Reviews
Users note that the drug helps in the fight against malignant formations. Some patients did not experience any side effects and received significant relief of the condition.
Price in Moscow
The cost of one ampoule of the drug( 15 mg) is approximately 1,400 rubles.
Bloomycin Analogues
Drugs with a similar active ingredient( bleomycin):
- verophilicin,
- bleomycetin hydrochloride,
- bleomycin-RON,
- bleocin,
- blenamax,
- blenoxane.
Synonyms
Antitumor drugs with a different composition:
- mitomycin,
- epirubicin,
- doxorubicin.
Conditions for dispensing from pharmacies
The product can be purchased at the pharmacy if a prescription is available.
Storage conditions and shelf life
The drug can withstand not more than +30 degrees during storage. Should be stored in a darkened place. Do not use the medicine after two years from the date of manufacture.