Gentamicin Ointment: instructions for use, price, analogs, reviews

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In connection with the increase in the number of cases of skin diseases, the choice of medicines is increasing, the effect of which is directed at combating various microorganisms. Among very effective drugs, a drug such as Gentamicin Ointment appeared.

This medicine has earned recognition in many patients due to its moderate cost, strong effect. We will consider today the instruction on the use of gentamicin ointment for children and adults, its analogs, the price and reviews about it.

Features of the drug

• The drug under consideration for long-term admission may cause the development of resistance to it of pathogenic microorganisms.
• If patients with CRF use a drug to treat a large area of ​​skin, resorptive action becomes possible.
• The drug may be partially absorbed into the bloodstream, and then manifest its therapeutic effect.
• If, after use of the drug for a long period of time, the curative effect does not appear, it is necessary to stop using it, consult a specialist.

Let's take a look at the composition of gentamicin ointment.

Gentamicin ointment from Aktavis( photo)

Composition of

The water tuba contains gentamycin sulfate 25 mg. This drug is an active substance of this drug.

Among the excipients are:

• solid paraffin( 52 - 54);
• liquid paraffin;
• soft white paraffin.

Next, you will find out how much is the gentamicin ointment.

Dosage forms

The drug is available in the form of an ointment, is intended for external use. Inside the tube contains 15 or 25 mg.medicinal product. The price of gentamicin ointment in Russia starts from 57 rubles, it depends on the amount of medicine.

Also "Gentamicin" is made in the form of powder, solution for injection.

Pharmacological action of

The drug in question is considered to be included in the group of aminoglycosides, ophthalmic agents."Gentamicin" is known as an antibacterial agent of a wide spectrum.

Farmakodinamika

Gentamicin shows activity against various microorganisms. It acts on multi-resistant strains, as well as the following microorganisms:

• Serratia spp.;
• Pseudomonas aeruginosa;
• Salmonella spp.;
• Escherichia coli;
• Shigella spp.;
• Staphylococcus spp.;
• Proteus spp.

"Gentamicin Ointment" does not affect anaerobic bacteria, fungi, viruses. This medicine has a bactericidal effect. It penetrates the cell membrane of microorganisms. Then, after the binding of gentamicin with the 30S subunits of the ribosomes, inhibition of protein synthesis occurs in pathogenic microorganisms.

Pharmacokinetics

• Penetrates the skin very poorly through the skin. When applied to undamaged areas of the epidermis, only 0.1% of the preparation is absorbed.
• If this medicine is applied to the injured area of ​​the epidermis, it will be absorbed much more easily. From the damaged, burned skin area( 1 cm2), the absorption of the drug is significantly increased( up to 1.5 μg).
• After a single application of the drug on the epidermis, its effect is noted for 8-12 hours. Gentamicin is excreted by the kidneys. It comes in unchanged form due to glomerular filtration.

On how gentamicin ointment is used in gynecology, for treating eyes, for acne and what responses it received from patients, read on.

Indications for the use of gentamicin ointment

The drug is prescribed for the control of infectious and inflammatory diseases, the occurrence of which provoked gentamicin-sensitive microorganisms. The drug is used to treat:

• of primary epidermal infections( furunculosis, infected acne, impetigo, superficial folliculitis),
• secondary epidermal infections( infectious eczematoid dermatitis, bullous dermatitis, bacterial superinfections, infected abrasions, viral / fungal epidermal damage, seborrheic dermatitis, anthrax carbuncle),
• andin the field of surgery for the treatment of infected varicose ulcers, infected skin cysts, minor wounds, superficial burns with infection( 3, 3A degree), cuts, cutaneous infectionsbstsessov after autopsy.

Gentamicin is intended for such use cases:

• Local .It helps in the therapy of such diseases: dacryocystitis, blepharitis, meibomite, conjunctivitis, blepharoconjunctivitis, keratoconjunctivitis, keratitis.
• Parenteral .It promotes the therapy of cholangitis, ventriculitis, acute cholecystitis, pneumonia, wound infection, sepsis, pleural empyema, infection of bones / joints, purulent infections of the epidermis, pyelonephritis, peritonitis, purulent soft tissue infections, burn infections.
• Outdoor .It helps in the fight against infected acne, superficial folliculitis, secondary bacterial infection, sycosis, furunculosis, pyoderma, infected varicose ulcers, infected skin wounds of different etiologies( insect bites, burns, hard healing ulcers, wounds).

Gentamecin is also used in the presence of optic neuritis, the complex treatment of otitis in adults, including external otitis, as an adjuvant in the presence of prostate adenoma in men.

Instruction of

The dosage for each patient is calculated by his treating doctor individually. To calculate the dose, the doctor takes into account the localization of the lesion, the severity of the disease, the degree of sensitivity of the pathogen.

• For external use of the drug, it is advisable to perform 3 to 4 treatments per day. Apply "Gentamicin ointment" to the problem area of ​​the epidermis thin layer. If there is pus on the affected area of ​​the epidermis, necrotic masses, they should be removed, then apply ointment. If the lesion of the epidermis is significant, it is recommended to apply a daily dose within 200 g of ointment.
• In the treatment of eye lesions, the drug is used in the form of drops. You need 1 - 2 drops, which are instilled in the conjunctival sac( lower).
• If the drug is administered intramuscularly, the single dose is 1 to 1.7 mg / kg. The daily dose is 3 - 5 mg / kg.

Gentamicin is contraindicated in pregnancy. This is due to the peculiarity that the drug has the ability to penetrate the hematoplacental barrier, thus achieving the fetus itself, its tissues. According to studies conducted by scientists on animals, gentamicin shows reproductive toxicity.

If a woman is breastfeeding a baby, she needs to stop breastfeeding for the duration of treatment. This precaution is necessary for the reason that gentamycin penetrates into breast milk. If there is no absorption of the drug from the digestive tract, side effects do not appear.

Gentamicin can also be used with prostatitis, as described in this video:

Contraindications

Among the contraindications we note the following:

1. The presence of hypersensitivity in the patient to the main component, which is gentamicin.
2. Presence of hypersensitivity to auxiliary components.
3. Presence of renal failure.
4. Age is less than 3 years.
5. Introduction of aminoglycosides.
6. In neuritis of the auditory nerve, it is necessary to use with caution the drug to treat a large area of ​​the epidermis.

Side effects of

The use of the drug in question can provoke the following side effects:

1. In the hematopoiesis system: granulocytopenia, anemia, leukopenia, thrombocytopenia.
2. In the digestive system: hyperbilirubinemia, vomiting, nausea, increased activity of transaminases in the liver.
3. In the urinary system: microhematuria, proteinuria, renal insufficiency, oliguria.
4. In the nervous system( CNS, peripheral UA): drowsiness, irreversible deafness, headache, functional disorders of the vestibular apparatus, hearing loss, deterioration of muscle conduction.

In addition to the aforementioned side effects, allergies can also occur in the form of skin rashes, itching, hives, less often in the form of edema Quincke. Also, when gentamicin is taken, paroxysmal positional vertigo may develop.

Special instructions

• The drug should be used very carefully in the presence of diseases such as myasthenia gravis, parkinsonism, disruption of the kidneys.
• Using "Gentamicin ointment" for medicinal purposes on a large area of ​​epithelium, one should not forget about the resorptive effect of the drug. In particular, this applies to those who suffer from kidney failure( chronic).
• Local use may contribute to a decrease in the sensitivity of pathogens of various kinds. In the absence of a noticeable therapeutic effect, the patient will need specialist advice.
• The incidence of allergic manifestations reaches 1.4%.Cases of sensitization become more frequent with the use of ointment for a considerable period. Side effects occur more often and more clearly after treatment with the preparation of extensive areas of the epidermis.

Interaction with other drugs

Gentamicin is concurrently used with antibiotics that exhibit oto-, nephrotic action:

• "Florimycin".
• "Streptomycin".
• "Kanamycin".
• "Ristamycin".
• "Monomycin".

It is also counter-indicative for simultaneous use of gentamicin with Furosemide.

Gentamicin incompatibility with the following drugs has been noted: heparin, drugs that are considered unstable at acid pH, and also with solutions having an alkaline pH.

Reviews

• About "Gentamicin Ointment" patients leave a positive response, everyone likes its effective bactericidal, antimicrobial effect.
• At the same time the cost of the medicine is quite affordable.
• With a low price, the quality remains at a high level.

Analogs

Note the following analogs:

• "Gentamycin sulfate".
• "Taizomed".
• "Streptomycin sulfate".
• "Tobrex 2x".
• "Kanamycin".
• Isofra.

On the use of gentamicin in ear diseases in a child will tell this video: