The problem of inflammatory diseases of the gastrointestinal tract( GIT), in particular, gastritis - today is one of the most topical in the field of gastroenterology. Among the reasons for this situation are eating disorders, environmental factors, stress, etc.
Omez is included in the standard regimen for gastritis. It belongs to the group of inhibitors of the proton pump - it has an antisecretory effect on the production of hydrochloric acid( HCl) by the basal cells of the gastric mucosa.
Omez for oral administration with gastritis is available as gelatin intestinal soluble capsules, each containing 10 or 20 mg of the main active substance, omeprazole, as well as pellets containing 10, 20 or 40 mg of the active ingredient. As auxiliary ingredients, mention may be made of sucrose, mannitol, sodium lauryl sulfate, purified water, etc. Various dosage forms of the release are provided with an instruction detailing how to take the drug.
Mechanism of action Omeza with gastritis
Being a prodrug, Omez only in the acidic environment of the stomach is converted into an active form - sulfenamide. The latter, in turn, blocks the functioning of the proton pump, inhibiting the transport of hydrogen ions to the gastric cavity and, as a consequence, prevents the formation of hydrochloric acid, the main irritant factor in gastritis. Omeprazole also has an indirect antimicrobial effect, creating an alkaline pH environment that is unsuitable for the normal functioning of pathogenic microorganisms and contributes to the accumulation of antibiotic concentrations.
Omez with gastritis against a background of hyperacid conditions is used as a monotherapy, as well as in the complex treatment of inflammatory processes associated with the Helicobacter pylori infectious agent.
How to take omez with gastritis?
The question of how to take the drug with gastritis - in what dosage and how many times a day - is decided by a specialist supervising the patient. Only strict observance of its instructions can guarantee the safety and effectiveness of its application. Most likely, the doctor will appoint the following scheme or plan of reception: to drink Omez in the form of tablets or capsules on 20 mg one time on an empty stomach during all course of treatment( 1 - 2 weeks).In this case, the symptoms of an irritated stomach( gastralgia, nausea, heartburn, etc.) stop very quickly: the therapeutic effect comes from the first days of the drug. If necessary, the treatment process can be adjusted accordingly, which, however, is the prerogative of a specialist. About the same as taking Omez with gastritis combined with Helicobacter pylori infection, the patient can also consult a gastroenterologist who will give exhaustive instructions on how to use it. Usually in this situation, it must be drunk in combination with antibacterial drugs - Clarithromycin or Amoxicillin and Metragyl( Metronidazole) - 1 capsule( 20 mg) 2 times a day for 7-10 days.
How to take omez with other medicines for gastritis?
According to clinical data, simultaneous administration of omeprazole with such drugs as caffeine, theophylline, non-steroidal anti-inflammatory drugs( piroxicam, diclofenac), beta-adrenoblockers( metoprolol, propranolol), as well as estradiol and lidocaine did not lead to a significant change in their concentration in the blood plasma. Also, there are no negative reactions or a weakening of the therapeutic effect, either in case of drinking Omez in combination with antacids with gastritis( Almagel, Gastal, Maalox, etc.).
Contraindications to taking omeza with gastritis
When appointing the drug, the gastroenterologist will determine how to take it with gastritis and how long it will take for the course of treatment. To maximize the effectiveness of therapy, the patient, in turn, must strictly follow his instructions. As for contraindications to treatment with Omega, it is worth highlighting the individual intolerance of the drug and its auxiliary components, age of up to 12 years, the period of pregnancy and lactation, as well as gastritis against the background of hypo- and anacid conditions. In the latter case, non-compliance with the instructions is fraught with the development of Achilles, which, as is known, increases the risk of malignant degeneration of the cells of the stomach. Also, the use of the drug is contraindicated in case of severe liver and kidney pathology.
Side Effects of
Among the side effects of Omega, which occur during its reception with gastritis, it is possible to distinguish disorders from the gastrointestinal tract( gastralgia, nausea, diarrhea or, conversely, constipation), central nervous system( migraine, dizziness, depressed mood), musculoskeletal system(myasthenia gravis, arthralgia), as well as manifestations of allergic desensitization of the body( skin itching, urticaria, erythematous rashes, bronchospasm).Also, changes in the blood formula can be observed, in particular, a decrease in the number of platelets and leukocytes, much less often - agranulocytosis. When observing instructions for the use of omezo, side effects are extremely rare. When canceling the taking of tablets or capsules, negative manifestations quickly regress.
In the pharmaceutical market today there is a very limited number of drugs for the treatment of hypersecretory conditions, and it is not known how long it will take to develop new drugs. Omez, thanks to its efficiency and affordability, will remain for a long time a standard in the application of a gastritis of a hyperacid form.