The drug Paracetamol helps with colds, headaches, but will this drug help if you drink it after a glass of wine, a mug of beer? Will the remedy have a curative effect if it interferes with ethanol?
Paracetamol
Paracetamol is an analgesic, antipyretic, widely used for the treatment of adults, children, the elderly. The drug is released in tablets, rectal suppositories, syrups, the active ingredient of the drug is para-acetaminophenol.
As an active ingredient, para-acetaminophenol is included in Children's Panadol, Antigrippin, Tylenol, Akamol-Teva, Acetaminophen, Iphimol, Kalpola, Cefekon D, Effergangan.
Properties
Antipyretic, analgesic effect is based on the effect of the drug directly on pain centers, thermoregulation in the hypothalamus. The inhibitory effect on the enzymes responsible for the development of the inflammatory process( cyclooxygenase) is noted only in the central nervous system, which explains the slight anti-inflammatory effect.
Penetrating into the tissues of internal organs, the drug does not affect the balance of electrolytes, is not able to block the synthesis of mediators of inflammation of prostaglandins. This feature makes the drug safe for the gastric mucosa.
Pharmacokinetics
The drug almost immediately after ingestion enters the blood plasma, the maximum concentration is observed after 40 minutes. Antipyretic effect, a decrease in temperature is noted 1, 5 hours after drug use.
The elimination half-life is from 1 to 4 hours. Paracetamol almost does not penetrate into breast milk, it can pass through the blood-brain barrier, the metabolism occurs in the liver.
Usage, dosage
- The drug is used to relieve headache, toothache, muscle pain, with painful menstruation, migraine, neuralgia, trauma, burns.
- The drug is used at high temperature for colds, flu, ARVI.
The maximum daily dose is for an adult:
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- with weight less than 40 kg - 2 g;
- with weight over 40 kg - 4 g.
The course of treatment - up to 7 days.
Contraindications
Paracetamol has a number of contraindications:
- Allergy;
- age under 3 years;
- kidney disease;
- severe liver damage.
The instructions to Paracetamol emphasize that with alcoholism, liver damage caused by the action of alcohol, the drug is administered with caution. This means that the risk of adverse effects of the drug may exceed the possible benefits of its use.
Side effects of
After taking the drug, there may be such side effects:
- Allergy - rash, skin rashes, Quincke's edema;
- dizziness;
- stomach pain;
- anemia;
- insomnia;
- lesions of the kidneys, liver.
On the video about the drug Paracetamol:
Interaction with alcohol
Paracetamol is a hepatotoxic drug, with frequent admission causes impairment of liver function. With alcohol compatibility, the toxic effect is greatly increased, the likelihood of developing cirrhosis increases.
Para-acetaminophenol, the active substance of this drug, is cleaved in the liver to form N-acetyl-b-benzoquinonimine, a dangerous toxin that is neutralized by glutathione. If the body lacks glutathione, a toxic metabolite accumulates in the liver, causing the death of hepatocytes.
But if glutathione is not enough, alcohol makes the liver more vulnerable to treatment with Paracetamol. Frequent use of alcohol with this anesthetic accelerates the process of drug disintegration in the liver with the formation of toxic compounds. Accordingly, alcohol with this drug is not compatible.
Possible consequences of
So, is it possible to drink a drug with alcohol? The use of paracetamol with alcoholic beverages, even in therapeutic doses, causes drug-induced hepatitis, leading to cirrhosis of the liver.
Paracetamol in combination with ethanol on the kidneys is negatively affected. Taking large doses of drugs with alcohol promotes the emergence of acute pancreatitis - inflammation of the pancreas.
The lethal dose of Paracetamol for adults is 150 mg / kg.
Through how much you can drink?
Alcohol after treatment Paracetamol can be taken no earlier than 4 hours later. At the same time, combining medicine and alcohol, and even more so drink a medicine with alcoholic beverages, is impossible because of the high risk of liver damage. It should not be allowed that the liver simultaneously had a double load: the metabolism of ethyl alcohol and para-acetaminophenol, the active component of Paracetamol.
Paracetamol after taking alcoholic beverages is consumed only if the body is completely cleared of ethyl alcohol and the products of its metabolism. Calculate how much time alcohol can be removed from the body, you can use an alcohol calculator.
In addition, there are limiting daily doses of alcohol, which in the treatment of Paracetamol can not be exceeded:
- vodka can drink no more than 130 ml;
- beer - no more than 1 liter;
- of wine - no more than 440 ml.
How to prevent liver damage
The close reception of paracetamol and alcohol can cause toxic liver damage, up to hepatonecrosis, a condition characterized by the death of liver cells( hepatocytes).This condition is characterized by vomiting, pale skin, lack of appetite, weakness.
Treatment of this condition should be handled by medical personnel, and before they arrive you can wash the patient's stomach, and then give Enterosorbents Polysorb, Enterosgel, activated charcoal.
Conclusions
In doses not exceeding therapeutic, Paracetamol may be taken 4-5 hours after taking insignificant amounts of alcohol.
If the dose of Paracetamol or alcohol is exceeded, or when the dose is close( less than 4 hours), this combination can cause poisoning, liver damage, cirrhosis. In the absence of medical care, taking a lethal dose of the drug is very high risk of death.