Cefazolin is a semisynthetic antimicrobial drug. Thanks to its use, it is possible to cope with bacterial microorganisms. Therefore, it is often used in the treatment of otitis and other pathologies of ENT organs. To obtain the desired result, use the remedy is recommended solely for the doctor's prescription.
Composition, form, package
Cefazolin is available in the form of a powder for making a solution. It can be used for intravenous or intramuscular administration. The containers with the preparation contain 0.5, 1 or 2 g.
The active component of the antibacterial agent is the sodium salt of cefazolin. Each vial contains 500, 1000 or 2000 mg of the substance.
Antibiotic is produced under different commercial names - for example, zolin, anceph, kefzol, etc. However, there are other drugs, the names of which coincide with the international one. They include Cefazolin-AKOS or Sandoz.
All these drugs are one antibacterial drug - cefazolin. It can be used as standard
, regardless of the specific name.
There are many manufacturers that manufacture this product.
Indications for use
Cefazolin helps to cope with different microorganisms, because it is used to treat such disorders:
- otitis media;
- lung abscess;
- pleural empyema;
- infectious lesions of the chest, which develop after surgery;
- bacterial pneumonia;
The following are the limitations to the use of cefazolin:
- susceptibility to drugs from the category of cephalosporins;
- age less than 1 month;
Mechanism of action
Cefazolin is considered to be the least toxic antibiotic from the cephalosporin group, which has a broad spectrum of bactericidal action. The drug is active against gram-negative microorganisms and Gram-positive bacteria.
In this case, fungi, viruses and protozoa are resistant to the action of this substance. Limit concentration of the drug is achieved after intramuscular use in an hour. If the agent is administered intravenously, an instantaneous reaction of the organism can be expected.
The instructions state that the therapeutic dose of cefazolin is maintained for 8-12 hours. At the same time, 90% of the drug leaves the body through the kidneys in its original state.
Instruction for use
The agent is injected as an injection intramuscularly or intravenously. In the first case, the medicine is prepared by diluting the contents of the vial in 5 ml of special water for injection or novocaine. Also, physiological saline may be used for this. The medicine needs to be injected deep into the muscles.
For intravenous use by a jet, a single volume of antibiotic should be mixed with 8-10 ml of saline. The drug is recommended to enter slowly - at least 4 minutes.
For drip intravenous use, the drug in a volume of 500-1000 mg should be diluted in a 5% solution of glucose. Also, 150-250 ml of saline solution can be used for this. It is recommended to administer the remedy within 30 minutes at a rate of 65-80 drops every minute.
The daily volume of the drug depends on the sensitivity of the bacteria to the drug and the severity of the pathology. On average, this indicator for adult patients is 1000-4000 mg.
Side effects of
For prolonged use, the drug often provokes such effects:
- allergy - itching, urticaria, fever, Stevens-Johnson syndrome.
Excessive use of the drug may cause dizziness, headache, paresthesia. With chronic kidney failure in humans, neurotoxic symptoms may appear. In this case, generalized convulsions, tachycardia, vomiting are observed.
If you have any unwanted symptoms, it is recommended that you cancel. If necessary, prescribe anticonvulsant therapy. The appearance of toxic reactions requires the implementation of hemodialysis.
Rules for the use of antibiotics in our video:
People who have a history of an allergy to penicillins or carbapenems often have a high sensitivity to cephalosporins.
When using cefazolin, there is a risk of positive Coombs and false-positive urine reactions to sugar.
The use of the product may cause an exacerbation of digestive pathologies. Especially often develops colitis.
Do not combine the substance with diuretics and anticoagulants. With the combined use of cefazolin and loop diuretics, a tubular secretion blockade can develop.
Aminoglycosides provoke an increased threat of kidney damage. When using drugs that block tubular secretion, the level of antibiotic in the blood increases and the likelihood of toxic lesions increases.
Instructions for use Cefazolin in our video:
Reviews about drops
The drug is considered an effective remedy, therefore, reviews about it are positive. Most often it is used to fight with sore throats when amoxicillin is ineffective.
Prices for Cefazolin
The cost of the medicine depends on the dosage, the capacity of the vial and the manufacturer. The price is in the range of 30-100 rubles.
The analogues of this drug include such drugs:
Cheap analogs of
Cefazolin is considered an inexpensive, but very effective drug. If its use is impossible for some reason, it will not be difficult to find cheap analogs. These drugs are lexin and cephalexin.
Cefazolin are issued under a variety of names, but all of these are considered synonymous because they contain the same active substance. These include:
- of ash;
Terms of dispensing from pharmacies
The medicine can be bought at the pharmacy only by prescription.
Storage conditions and shelf life
The substance is recommended to be stored out of the children's access area in a dark place. The temperature should be a maximum of 25 degrees. It is permissible to store the medicine for 3 years. The finished solution can be used for a maximum of 1 day. The storage temperature should be 2-8 degrees.
Cefazolin is considered an effective tool that helps cope with bacterial microorganisms. To achieve good results, you should clearly follow all medical recommendations and not engage in self-medication.