Anauran is a combined drug for topical use. It is used mainly for the treatment of ear diseases, it is used to prevent complications after operations and various surgical interventions on other ENT organs.
Composition, form of release, packing
These are ear drops, produced in bottles-droppers from the darkened glass. The standard volume is 25 ml.
Packages are made of cardboard. The composition contains:
- Polymyxin B sulfate 10 thousand IU.Has a bacteriostatic effect on most bacteria.
- Neomycin - 3.75 thousand IU.Aminoglycoside with a wide range of action.
- Lidocaine hydrochloride. Eliminates pain, has a local anesthetic effect.
Additives include benzalkonium chloride, glycerol, propylene glycol, purified water.
Manufacturer
Drops are produced in Italy by ZAMBON, S.P.A.
Indications for use
Anaurean is one of the few drugs that can be used in the treatment of chronic and acute otitis media. Assigned before the appearance of a ruptured eardrum. Drops can be used for postoperative complications, for tympanoplasty, anthotomy, and some other procedures.
Contraindications
The drug should not be used with:
- hypersensitivity to any component drops,
- perforation of the tympanic membrane,
- treatment with antibiotics that adversely affect hearing.
With caution should be used with increased flaking of external ear tissues or with hyperemia.
Mechanism of action
The drug has antibacterial and analgesic action. Neomycin has a disastrous effect on most types of pathogenic microorganisms, but it has an insignificant effect on Streptococcus spp.
Polymyxin has a potent bactericidal action, but it has no activity on fungi and Gram-positive cocci. It performs a local-irritant function. Lidocaine quickly eliminates pain and itching.
No pharmacokinetic studies were performed. This is due to the fact that it is intended solely for local use. The appearance of systemic effects is unlikely.
Instruction for use
Anuran is used locally. During the procedure, it is necessary to tilt the head in the opposite side. Using a pipette, 4-5 drops are ordered three times per day. Children are prescribed 2-3 drops with the same multiplicity.
After inserting the drug into the outer ear, fix the position of the head for a few minutes to better move the drops to the department in which there is an inflammatory process.
How to drip drops in the ears, see in our video:
Side effects of
Systemic effects do not appear due to low doses of drug use. With prolonged treatment or failure to comply with the dosage, it is possible to develop systemic effects, for example, ototoxicity and nephrotoxicity due to neomycin absorption.
Possible development of local reactions:
- peeling of the external auditory canal,
- hyperemia,
- pruritus.
These symptoms disappear when the drug is withdrawn.
Overdose
Information on reactions due to overdose is not known. Perhaps the development of local reactions.
Special instructions
Anuran is used exclusively for the treatment of ear disorders. With persistent infection, local treatment is supplemented with a systemic intake of antibacterial agents. Long-term use without the supervision of a doctor may cause the development of superinfection resistant to the drug microflora.
In children under one year, medicinal drops are used only in case of emergency under medical supervision. The same applies to women during pregnancy. In the lactation period, risks are first assessed, and then course treatment is conducted.
Drug Interaction
Not recommended for use with:
- Nethylmicin
- Streptomycin,
- Amikacin,
- Gantamicin,
- Multimycin.
Together with Anauran, these preparations intensify ototoxic effect.
Reviews about drops
Many patients are satisfied with the drug, since the desired therapeutic effect is created with the classical dosage indicated in the instructions. It is noted that the remedy is well tolerated by children, it relieves painful symptoms.
Negative feedback is rare, often associated with side effects that occur due to a violation of the admission scheme. Some patients with hypersensitivity on the third day or later have an itch, which is the result of fungal attack.
But the likelihood of developing candidiasis is higher if antibiotic suspensions or tablets are used simultaneously with topical administration of drops.
Prices for Anauran
Depending on the characteristics of the pharmacy network and the location of the drug starts at 250 to 400 rubles.
Analogues of
There are no structural analogues. Analogues on the pharmacological effect:
- Otinum,
- Otofa,
- Sofraks.
Cheap analogs
- Gebryolone,
- Lidocaine,
- Vitimixin. Synonyms of medication
Auridexan, Otypax.
On the photo analogues of Anauran
Conditions for dispensing from pharmacies
Buy Anaurean is available only on prescription, because it is an antibiotic of combined action.
Storage conditions and shelf life
The drug can be stored in a dark place. It is necessary to make sure that the medicine is not free from children. Shelf life is 3 years. In the place of storage, the temperature should be within 15-25 degrees.