Blemaren is a drug that dissolves uric acid stones in the kidneys and bladder. The remedy is used strictly for the intended purpose, and is taken only after consultation of the doctor. Urolithiasis or urolithiasis is an ailment in which calcium salts are precipitated in the kidneys and urinary bladder with the formation of stone stones. They can be of a different nature, so there is no universal medicine for urolithiasis.
Blemaren
Virtually all compounds that appear in the urine are water soluble. However, like any salt, these substances have a certain limit of solubility. It is determined by the acidity of urine. Normally, the pH level is about 6, but when this value is lowered, some of the oxalate salts can not dissolve sufficiently and precipitate. These depositions, accumulated, and form stones.
Blemaren refers to the type of drugs that have the property of preventing and the appearance of concrements, and dissolve them by increasing the urinary pH to 6.6-6.8.
Form
The preparation is produced in 2 kinds:
- dry granular powder for dissolution in water. Packing - as a rule, 200 g, is completed with a measuring spoon - for 3 g. The cost of packing - from 1390 r;
- effervescent soluble tablets - before use, tablets also dissolve in liquid: water, tea, compote. The plastic tube contains 20, 80 and 100 tablets. The price depends on the capacity of the package: a tube with 80 tablets costs on average 1077 r, 100 - from 1230 r.
The daily dose of the drug is determined by the pH of the urine. This value is calculated by the reaction of the indicator paper. The color on the test strip is compared with the standard and the acidity of urine is determined. Depending on the data, calculate the dose. Indicator paper and instructions for use are included.
Composition
Granular powder contains the following substances - per 100 g:
- 39,90 g - citric acid;
- 27,85 - potassium bicarbonate;
- 32.25 g - trisodium anhydrous anhydrous citrate.
The composition of the tablet is as follows:
- 1197 mg of citric acid;
- 967, 5 mg of potassium hydrogen carbonate;
- 835.5 mg of trisodium citrate.
As auxiliary substances are used: sodium saccharin, lemon flavor, mannitol, lactose, adipic acid.
In the video description of the drug Blemaren:
Principle of action
The action of the drug is based on changes in the pH of the urine. When the tablet is dissolved in the liquid, hydrocitrates of potassium and sodium are formed. Once in the kidneys, the compounds alkalinize the urine, raising the pH to 6.6-6.8.And with this value, the oxalate calcium salts begin to actively dissolve. Accordingly, the concretions formed by this kind of salts, stop in growth, gradually collapse, and dissolved salts are excreted in the urine.
The big plus is blemarene, which helps dissolve calcium salts, it prevents calcium washing away. Derived components of the drug after 24-48 hours, so that excess accumulation of potassium or sodium ions does not occur, and the total acid-base balance in the body is not violated. However, this is legitimate only if the kidney is relatively normal.
Indications
Blemaren is used in the treatment of a number of diseases. The active substances in its composition possess 100% bioavailability, are absorbed in the intestine and enter the blood within 20-30 minutes after administration. The components of the drug are excreted by the kidneys in an unchanged form. In treating any form of kidney disease, this is a very important indicator.
Assign the drug in the following cases:
- to dissolve and excrete oxalate calcium stones, and to prevent their occurrence if the acidity of urine is high;
- for destruction and excretion of stones, partly consisting of oxalate salts - not less than 25%;
- for alkalinization of urine - for example, in cases where the patient takes cytotoxic drugs or preparations for the removal of uric acid. In this case, its acidity sharply increases and there is a risk of precipitation of oxalate salts;
- with gout - the condition of such a patient depends on the level of uric acid in the blood and urine. Reception blemarena allows you to regulate the concentration of uric acid;
- in the treatment of hyperuricemia - an increase in the level of uric acid in the blood;
- in porphyria of the skin - treatment of the erythropoietic form of the disease requires the use of a large amount of hydroxyurea. Blarmarene allows to maintain the optimum pH level.
Instruction for use
The average daily dose assumes the intake of 12 g of powder or 3-4 tablets. In practice, the dose is determined by the pH level.
During the day before the medication, that is, at least 3 times, the urine pH is measured, for which indicator paper is used. The daily dose is matched correctly in the event that during these days the pH of the urine is within certain limits.
The range is calculated for different forms of the disease:
- 6,2-7 - urate stones dissolve;
- 7,5-8,5 - are necessary for the dissolution of cystine deposits;
- 7,2-7,5 - this level is preserved in the treatment of porphyria of the skin;
- 7,0 - the pH value when using cytostatics.
The data is measured and recorded in the calendar so that it is possible to adjust the treatment. In accordance with these indicators, the daily dose is increased to 18 g or 6 tablets, or reduced to 6 g and 2 tablets.
The dose is divided into 3 meals, taken after a meal. Pre-and the powder and tablets are dissolved in 200 ml of water, tea, fruit juice, alkaline mineral water. Coffee, strong tea, sour mineral water for obvious reasons are not allowed.
- No data on the use of blemarin in pregnancy or breast-feeding. During this period, you can take it only under the supervision of a doctor.
- Admission is not recommended for children under 12 years old: there is no data on the reaction of the child's organism to the use of the drug, since the target group of the drug is made up of patients of a much older age.
Side effects of
Despite the overall safety of the drug, some side effects associated with the underlying disease are possible.
So, if the kidney function is impaired, the appearance of:
- heartburn, eructation;
- flatulence, diarrhea;
- abdominal pain, not associated with flatulence.
Side effects such as swelling and an allergic reaction can occur if any of the components of the drug are irritating.
Contraindications
There are a number of ailments in which the use of blemarene is not allowed:
- sensitivity to any component of the drug. In this case it is necessary to use an analogue with another composition;
- metabolic alkalosis - in this case, the reaction of blood and urine and so is alkaline and its further alkalinization will exacerbate the condition;
- Renal failure is chronic or acute. The process of urine formation is difficult, it can not be burdened with regulating compounds;
- infectious diseases of the urinary system - most pathogens break down lactic acid;
- arterial hypertension or other conditions in which the patient is forced to comply with a very strict salt-free diet. And, more correctly, to limit the input of sodium ions. The composition of the preparation, as indicated, includes trisodium citrate;
- if the pH of the urine is for any reason higher than 7, the medication should be discarded.
Special instructions
In addition, when using blemarene, you need to follow other recommendations:
- A salt-free diet is a requirement that must be met for many diseases. If such an ailment is present in the history, the drug should not be used.
- It is compulsory during the treatment to observe a diet that restricts foods with a pronounced acid reaction and contain purines. Basically, these are protein products: meat, herring, sardines, sausages.
- It is necessary to ensure a sufficient volume of water - about 2-3 liters per day. If the diet during the disease requires water restriction, then the drug should be canceled.
- Blemaren weakens the action of cardiac glycosides. If the drug is taken with non-steroidal anti-inflammatory drugs or antihypertensive drugs, potassium accumulation is possible. The level of salts in the blood should be monitored during the therapeutic course.
- It is permissible to use blemaren in diabetes mellitus, since the drug does not affect the level of sugar.
- You can not prescribe a medicine that is blemish-free in patients with congenital intolerance to galactose.
- High urine incubation is not allowed - above 7.8, for a long time. In this case, the risk of forming a layer of phosphates on concrements, which will not allow the stones to dissolve, is great.
Analogs of
There are no analogues with identical composition. The following drugs have the same pharmacological effect:
- rovatinex;
- cyston;
- urolesan;
- Uralite U.
Reviews
Blamarin is prescribed for loosening and gradual dissolution of uric acid stones. Duration of the course and dose is selected individually. If the stone is large, then it will take a long time to drink the drug.
Blemaren is prescribed for complex combined concrements, and sometimes its appointment seems paradoxical at first glance: for example, experts often recommend drinking blemarene together with cystone with urate-phosphate stones. This is quite true if the proportion of urinary acid salt in the concrement reaches 30-40%.
The drug is very effective: patients' reviews indicate dissolution and removal of stones not only in the kidneys, but also in the joints. However, the course of treatment should be appointed individually, taking into account the composition of the stones and the condition of other organs. With renal failure, blemar can cause considerable harm.
It is very important to maintain the recommended pH of the urine: fluctuations both in one and the other side lead to the formation of different types of deposits, which significantly complicates the treatment.
Blemaren is a drug whose task is alkalinization of urine in order to dissolve and excrete uric acid stones. The drug acts only on one group of stones and in all other cases, as the doctors say, no positive effect will not.