The drug Dostinex actively acts on the brain, reducing the concentration in the blood of the hormone prolactin. Alcohol abuse increases prolactin secretion by the pituitary gland. Such a controversial effect is caused by the simultaneous administration of these substances the effect of an overdose, makes the treatment useless.
Dostinex - description of the preparation
Producer of the drug Dostinex is an Italian company Pfizer. The form of the release is a tablet of 0.5 mg of cabergoline.
The active substance cabergoline belongs to the group of dopaminomimetics - drugs that stimulate dopamine receptors of the hypothalamus, basal nuclei of the brain.
Properties
Cabergoline - a synthetic compound, according to the formula corresponds to an ergot alkaloid, activates the D2-dopamine receptors of the hypothalamus, suppressing the production of the prolactin hormone.
When taking Donstinx tablets, it completely enters the bloodstream after 4 hours. Half-life:
- in patients with hyperpolaktinemia - from 79 to 115 hours;
- in the control group of healthy people - up to 68 hours.
In 72% of patients receiving treatment, the drug is detected in the body and after 240 hours. With hyperlactinemia, the concentration of the drug in the therapeutic dose is maintained up to 4 weeks. In women taking Dostinex to stop lactation, the content of the drug in the blood and its activity gradually decreases within 2-3 weeks.
Influence of the hormone prolactin on males and females
Excess prolactin in males leads to a decrease in the synthesis of male sex hormones, a change in the female pattern.
In women, prolactin stimulates lactation, regulates the menstrual cycle, is necessary for ovulation.
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Increases prolactin after:
- food intake;
- physical activities;
- thermal procedures;
- stressful situations.
Increase in prolactin is observed in chronic alcoholism. With a single intake of alcohol in a healthy person, the level of prolactin decreases. A low concentration of this hormone in the plasma is observed with abstinence.
Indications
Prolactin level increases during pregnancy, diseases of the pituitary and hypothalamus, liver cirrhosis, lowering of thyroid function.
Dostinex appoint, if necessary:
- , termination of lactation;
- treatment of conditions caused by hyperprolactinemia;
- of Parkinson's disease;
- therapy for pituitary adenoma.
Analogues of Dostinex include Agalates, Bergolak, Kabergolin.
Contraindications
Dostinex with caution prescribed for diseases:
- ulcer, internal intestinal bleeding;
- of hepatic insufficiency;
- mental disorders, memory impairment;
- concomitantly with drugs that lower blood pressure.
Side effects of
The drug Dostinex with long-term use( more than 6 months) in nearly 70% of cases is accompanied by side effects. They arise after 2 weeks of taking the drug, after the withdrawal of treatment, side effects disappear.
Action on the nervous system manifests itself:
- by dizziness;
- syncope;
- drowsiness;
- by depression.
There are also disorders of digestion, possibly the development of gastritis, dyspepsia. Arterial pressure is reduced as much as possible after 6 hours after taking the medicine.
Patients suffering from Parkinson's disease may experience drowsiness, sudden falling asleep when treated with cabergoline.
Compatibility of Dostinex and Alcohol
Alcohol has an effect on the pituitary and hypothalamus. A single intake of alcohol stimulates dopamine receptors, causing a release of dopamine, a sense of satisfaction, an increase in the level of prolactin.
With alcoholism, the synthesis of dopamine is depleted, the patient needs all new doses to at least overcome the state of withdrawal.
Signs of damage to the pituitary gland are manifested:
- decreased appetite, weight loss;
- dryness, pallor of the skin;
- decline of strength, lethargy;
- fragility of bones.
The combination of alcohol with Dostinex represents a danger for people who rarely drink alcohol. Given that Dostinex is prescribed to reduce prolactin, in such people the level of prolactin in the blood is increased.
Drinking a glass of alcohol-containing beverage, they dramatically increase the concentration of prolactin in the blood plasma. This leads to the fact that the dosage of the drug prescribed by the doctor for treatment is insufficient, which reduces the effectiveness of treatment.
Possible consequences of
A single dose of Dostinex and alcohol will not bring much harm. However, it should be borne in mind that the action of hormones is not fully understood. It is impossible to predict exactly how the overdose will behave.
So, increasing the dose intensifies the side effects, is accompanied by:
- stool disorder, nausea, vomiting;
- reduced blood pressure, syncope;
- convulsions;
- confused consciousness, the development of psychosis.
The state of health worsens because of strong palpitation, weakness, headache, sweating, leg cramps, confused consciousness, hallucinations.
Rules for admission
Drinking alcoholic beverages when taking Dostinex makes treatment meaningless. The drug effect of the drug develops long-term, its content in the blood is kept in therapeutic concentrations for 3-4 weeks. The intake of alcohol crosses out many days of effort aimed at reducing prolactin. Let's consider through how many after alcohol it is possible medicines and on the contrary.
Drinking alcohol after preparation
In order not to reduce the effectiveness of the action of Dostinex, it is permissible to drink alcoholic beverages once:
- in treatment for cessation of lactation - after 3 weeks;
- in the treatment of hyperlactinemia - after 4 weeks.
With alcohol abuse, the level of the hormone progesterone is reduced, Dostinex is not prescribed such a patient.
Taking the drug after alcohol
When you begin treatment with Dostinex, you need to be sure that the blood does not contain alcohol. Calculate the time required for the complete elimination of ethyl alcohol, you can yourself using an alcohol calculator.
So, if a woman weighing 60 kg, drank a bottle of light beer in the evening, then in the morning her alcohol will not be found in her blood.
Conclusions
Alcohol can not be combined with treatment by Dostinex. Doctors, prescribing treatment with this drug, emphasize that, although contraindications do not indicate incompatibility, it is also dangerous to take them at the same time.
Drinking alcohol and taking Dostinex:
- reduces the effectiveness of treatment with macrolide antibiotics;
- worsens the liver in cirrhosis;
- increases side effects;
- increases the risk of allergic reactions, hypotension.
Opinions of doctors on whether it is possible to drink Dostinex with alcohol are categorical, in all reviews, it is noted that such combination of a hormonal drug and a depressant, which is alcohol, is inadmissible.
Simultaneous reception negatively affects the nervous system. Sudden sleep, convulsions, hallucinations, confusion, depression - any of these symptoms may appear after drinking alcohol and medication.
The categorical response of doctors is also explained by the fact that the interaction of drugs containing cabergoline with alcohol has not been studied. Predicting exactly how such a combination will work is impossible. Risk increases when planning pregnancy and treatment with Dostinex.