Tryptans - effective medications for migraine

1 Indications for use

In almost all cases, a sick person does not understand how to interrupt the progression of the disease as effectively as possible and to calm the attacks. Such people start taking analgesics, but the decision comes late, and in almost all cases the effect of taking analgesics is extremely low and very short-lived. Due to the fact that the effect of analgesic drugs is barely noticeable, the patient decides to increase dosages or dilute analgesics with other drugs against headache. However, this only leads to an aggravation of the current situation. In addition, the risk of kidney damage increases manyfold. Excessive use of drugs of this nature can lead to gastritis and cause a drug-induced headache.

Thus, a person has an acute need for a drug that would rebuff the migraine and at the same time cause minimal harm to the body. So, in medicine there were special preparations from migraine - triptans. Special preparations against migraine triptans are drugs based on the substance-agonist serotonin. These substances have a selective effect on serotonin. Means of this nature began to be created in the near 90-ies of the twentieth century.

Triptans from migraine are intended in cases of both the presence of an aura and its absence. Aura is a series of specific symptoms that characterize migraines. In general, the aura begins to manifest itself a few days before the onset of the migraine itself and is somewhat of a harbinger of pain announcing its arrival. A person can learn to determine by the aura the period when the migraine will become aggravated and make itself felt.

2 Principle of action of the

group Most people assume that absolutely all tryptans from migraine exert an identical effect on a person. However, it should be noted that those drugs that helped to cope with migraine to one person, can fail in the case of another and prove to be completely useless. In general, a person can be approached only 1 or 2 drugs from all existing. Therefore, the list of necessary funds for treatment is made by the patient himself. However, all this should be controlled by a doctor. The patient only notes whether any given drug has any effect and helps to cope with migraine. For the final choice, the patient needs to test the means. Each drug is used during 3 attacks, and its effectiveness is noted, then only the most effective ones are left. The rest of the money should be discarded. The principle of the action of triptans:

1. The agents affect the receptors located on the walls of the vessels. This effect contributes to the narrowing of excessively dilated vessels, which affects the reduction of pain syndrome.
2. Drugs have very high selectivity, as a result of which the effect of tryptanes is directly on the vessels of the meninges, bypassing other peripheral and coronary vessels.
3. These drugs are also blockers of the pain syndrome at the nervous level. They directly affect the receptors of the spinal cord, which leads to a significant decrease in susceptibility to pain.
4. The drugs give some guarantee of preventing the recurrence of pathology. In addition, they eliminate accompanying migraine symptoms such as light and phobia, nausea and vomiting.

Triptans are a new generation of drugs, so some of the funds are still undergoing clinical trials. Despite this, most drugs have already passed the stage of clinical trials and proved to be effective. Triptans significantly exceed all other means of identical effects. These medicines are the main ones in the fight against migraine and have achieved unprecedented successes in this field. Migraine is divided into types, and tryptans must be selected based on the type of disease.

3 The list of medicines

Despite the relative youth of these funds, the triptans have already been divided into two generations. The first is only one drug - sumatriptan. This drug is the "forefather" of all means of this nature. This medicine is the most studied at the moment and is the standard of struggle against migraine. In the market this remedy is present in two forms: tablets and spray. The maximum effect of sumatriptan in the case of the use of tablets comes in 2.5 hours, and if you use a spray, the peak effect of the drug will come in 1.5 hours.

The second generation of triptans include modern drugs and in general all the drugs released after sumatriptan. There are a lot of such drugs, and no less than really useful medicines that have the necessary effect. It is worth saying that the second generation products are produced mainly in the form of tablets. In addition, the second generation has been poorly studied, and most clinical trials are still under way. It is necessary to note the most effective second-generation drugs:

1. Naratriptan. This tool effectively removes the pain syndrome. Significant relief comes within 1 hour after taking the drug, and the maximum is achieved after 2 or 3 hours.
2. Fluorotriptan. This drug is much weaker than the "forefather", but it is also weak in the occurrence of side effects.
3. Zolmitriptan. The fastest drug. A palpable effect occurs after 15 or 20 minutes, the maximum is reached after 1 hour. Especially effective in acute and very severe pain.
4. Risatriptan. It can be said that this drug is a clone of sumatriptan.
5. Relpax, or eletriptan. In general, it has a similar effect to the "forefather", but is more selective to the vessels of the brain.
6. Almotriptan. This drug has surpassed its ancestor. Has an effect that surpasses the effect of sumatriptan 4 times. The maximum impact occurs in the interval between 1.5 and 4 hours.

4 Daily dosage

The instruction for the preparation will be as follows: the optimal dose for all agents is 1 tablet per 1 reception. Increase in the dose is allowed only in the absence of any effect when trialing a multitude of tryptanes. Increase dosage should be consulted by a doctor;repeated use of the tablet is allowed no earlier than two hours after the first. The daily dosage for each product is different. The medicine is used together with a lot of water. Apply the tryptane after the end of the aura.