1 Dosage and action of the drug
- Drugs stimulate the narrowing of the vessels of the brain membranes, this occurs after the vessels of 5-HT1B receptors are activated and relieves painful pulsation.
- Inhibition of the isolation of vasoactive and algogenic proteins from the trigeminal nerve fibers. This reduces soreness and relieves inflammation.
- The tee nerve becomes less sensitive to pain when taking triptans.
- Pain decreases with vasoconstriction, after the action of the triptans on the receptors of the vascular wall.
- Drugs of this group do not affect the peripheral and coronary vessels, while acting on the hard shell of the brain.
- Drugs in this group eliminate symptoms such as nausea, vomiting, fear of light or noise, which is very important.
The first generation of triptans is the most studied. At the same time, the second generation of triptans has improved pharmacological properties. Some second-generation drugs are still undergoing clinical trials. To such carry фроватриптан and eletriptan.
Triptans from migraine are released in various dosage forms, such as tablets, injections or nasal sprays. The most commonly used tablets.
The recommended dose of these drugs is one tablet, which should be taken as soon as possible after the onset of an attack.
At the time of aura, the medicine should not be taken as well as for the prevention of migraine attacks.
Drugs of this group to date a fairly large number. These include imigran, amigrenin, rapimedom, zomig, rlpax, naramig, sumatriptan, sumamigren, trimigren, antimigren.
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2 Difference from compositions based on ergot alkaloids
Since the thirties, migraines have been treated with preparations based on ergot alkaloids. These are derivatives of ergotamine and dihydroergotamine. They block serotonin receptors, but at the same time affect adreno-and dopamine receptors. These drugs, in contrast to preparations of the ergotamine group, have many side effects.
One of the most common side effects of drugs in this group are disorders of the gastrointestinal tract. When taking these drugs, together with a reduction in headache, nausea increases, and weakness and malaise appear. With the use of triptans, these symptoms disappear.
Drugs of this group, in contrast to tryptans, cause dependence when taking more than 10 mg per week or any other dose more often than twice a week. Physical dependence manifests itself as an irresistible urge to take an ergotamine pill, or a condition that mimics a migraine attack.
Preparations of the group of triptans allow you to quickly stop migraine attacks, remove the additional symptoms accompanying the attack, while not exerting a negative impact on the central nervous system without causing hallucinations and addictions.
3 Contraindications to the use of
Triptans are contraindicated in people with circulatory disorders in the brain or those with cardiovascular problems, since they reduce the lumen of the coronary vessels to twenty percent.
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Despite the fact that there is a large number of drugs in this group, it is impossible to predict which of the drugs will be most effective. The choice of triptans for migraine depends not on the doctor, but on the patient, because only he can determine which of the drugs is most effective.
And remember: to confirm the diagnosis and find out the causes of the disease should consult a doctor.