Corinfar: instructions for use, reviews, analogues, price, contraindications

click fraud protection

For the treatment of stable and Prinzmetal angina, various means are used, the cost of which can reach up to a thousand or more rubles. But are there inexpensive and effective medicines? Yes. One such is Corinth.

Therefore, today we will review the instructions for the use of tablets Corinfar, its price, reviews, analogues and indications for use.

Features of the preparation

Corinfar has an optimal composition, as well as good pharmacological and pharmacodynamic properties, which causes its popularity and effectiveness.

Composition

One tablet of drug-Va contains 10 mg of nifedipine. Also included in the formulation are excipients( in mg):

1. lactose monohydrate( 15.8);
2. potato starch( 15.7);
3. MCC( 15.5);
4. Magnesium stearate( 0.3);
5. Povidn K25( 2,7);

The film membrane of Corinfar consists of hypromellose, macrogol 6000 and 35000, quinoline yellow dye, titanium dioxide and talc.

Dosage Forms

Corinfar is a yellow tablet covered with a film. The tablets have a biconvex form and sloping edges. The average cost of 100-140 rubles.

Pharmacological action and pharmacodynamics

Corinfar is characterized by anti-anginal and hypotensive action. The described time of onset of the clinical effect is 20 minutes. The action lasts for 4-6 hours.

Pharmacokinetics

Corinfar has a high absorption( more than 90%) and bioavailability( more than 50%).The latter is increased during meals. Also, the drug is characterized by the effect of the first patency through the liver.

Corinfar medication penetrates the barrier of the placenta and GEB, which causes contraindications. It also binds albumin to 95% and is metabolized in the liver. The excretion through the kidneys is within the limits of 60-80% of the consumed dose and 20% with bile.

Indications

Corinfar is prescribed for chronic angina pectoris or Prinzmetal, as well as hypertension. Its effectiveness in these conditions is due to pharmacokinetic and pharmacological properties.

• During the first trimester of pregnancy, it is forbidden to prescribe Corinfar, as the drug can carry a teratogenic effect. The administration of the drug in the second and third trimesters of pregnancy depends on whether the expected positive effect exceeds the possible negative.
• Because Corinaf penetrates into breast milk, its use during lactation is prohibited.
• With caution, the drug is prescribed to persons younger than 18 years of age, since safety and efficacy have not been established in this group.

On how to take Corinfar, we will tell you further.

Instructions for use

Corinfar is applied inside, after eating, while not chewing the tablet, but you can drink it with any amount of liquid. You can take and while eating, however, it delays the absorption of nifedipine in the digestive tract, although it does not reduce it.

The dosage depends on the patient's condition, always selected individually. The standard dose should be reduced if the patient suffers from cerebrovascular diseases, refers to the elderly.

There are standard dosage regimens that depend on the diagnosis:

• With angina pectoris. Start with 1 tab.2-3 r.in a day. If the effect is insufficient dosage is increased to 2 tablets, however, take 1-2 p.in a day. The maximum possible dosage is 4 tablets per day.
• With essential hypertension. The average dosage is 1 tab.2-3 r.in a day. If the effect is poorly expressed, the dosage is increased to 2 tablets, which are important to take 2 times a day. The maximum dose is the same - 4 tablets.

How long the course will last is determined by the doctor.

Contraindications

Contraindicated in prescribing Corinfar for sensitivity to nifedipine and other derivatives of 1,4-dihydropyridine, other components of the drug, as well as:

1. arterial hypotension;
2. cardiogenic shock;
3. collapse;
4. CHF, including decompensated condition;
5. marked stenosis;
6. Non-staged angina pectoris;
7. acute infarction;
8. concurrent administration of Rifampicin;

When taking precautions, the drug can be prescribed for stenosis of the mitral valve, obstructive cardiomyopathy, bradycardia or tachycardia, weakness of the sinus node, hypovolemia, severe circulatory disorders of the brain, hemodialysis, gastrointestinal obstruction and simultaneous use of beta-blockers, digoxin.

Side effects of Corinphar

There are many possible side effects of Corinfar, but only because it is well studied. The risk of serious complications such as tremor or paresthesia, violations of the liver is low and arises only if long-term intake or use of high doses.

The side effects of taking Corinphar include:

1. tachycardia;
2. arrhythmia;
3. swelling of the legs;
4. vasodilation;
5. syncope;
6. headache;
7. weakness and fatigue;
8. drowsiness;
9. depression;
10. dyspepsia;
11. dryness in the oral cavity;
12. flatulence;
13. arthritis;
14. myalgia;
15. anemia;
16. agranulocytosis;
17. leukopenia;
18. thrombocytopenia;

In a small part of patients, at first or with a sharp increase in dosage, angina may be noted or myocardial infarction may occur, which is weakened upon cancellation. Very rarely there are complications such as gingival hyperplasia, pruritus, hives, dermatitis of various forms, visual impairment, pulmonary edema, weight gain, bronchospasm, galactorrhea, impaired renal function.

Special instructions

The effect of the drug, namely, a reduction in pressure, may increase if, simultaneously with it, the following is accepted:

1. tricyclic antidepressant;
2. nitrate;
3. cimetidine;
4. anesthetic in inhalation form;
5. diuretic;

Also nitrates with Corinfar can strengthen tachycardia. Other drug interactions should also be indicated:

• With Diltiazem. Reduces the concentration of quinidine in plasma.
• With cephalosporins. Increases their concentration.
• With lithium preparations. Intensifies side effects like vomiting and tremors.
• With procainamides, quinidine. Increases the risk of increasing the length of QT.
• With grapefruit juice. The metabolism of the active substance of the drug is suppressed.

That's why it's important to take responsibility responsibly to the appointment of Corinth.

Reviews

After analyzing the reviews, you can confirm that they keep at around 4/5. Almost 90% of patients note the immediate help of the drug for angina pectoris, as well as general improvement in well-being. In this case, they note the action of the drug is prolonged, which can also be noted as a plus.

Negative responses are based not on the inefficiency of the drug, but on its incompatibility with many drugs, a large list of side effects, and contraindications.

Analogues of

There are preparations that can be called structural analogues of Corinfar, like:

1. Adalata;
2. Vero Nifedipina;
3. Retard calzagard;
4. of Cordafen;
5. Niefebene;
6. Osmola Adalat;
7. Nifedipine;
8. Nifedipine FPO;
9. Corinthard retard;
10. Niacardia;
11. Nifadila;
12. Cordaflex;
13. Cordypin;
14. of Nifesana;
15. Sponify 10;
16. Phenyhydidine;
17. Nifehexal;
18. Nifedex;
19. Nifedikapa;
20. of Nifedikor;
21. Nifecard;
22. Nifelata;
23. Sanfidipine;

However, it must be remembered that only a doctor can prescribe such drugs, since the pharmokinetic and pharmacological properties of these drugs differ.

The following video will tell even more about such a preparation as Corinfar: