Detailed instructions for the use of Euphyllin: reviews, side effects, indications

The pharmacological industry can offer a variety of medications to eliminate bronchial obstructive syndrome. However, the oldest and most inexpensive drug called Eufillin remains the most effective. So, let's consider with you the instruction on the use of the drug Eufillin by children and adults, prices, reviews about it and available analogues.

Features of the drug

Eufillin is a bronchodilator that relaxes the muscles of the bronchi and dilates the heart vessels. Its important feature is that it dissolves in water, and this causes the possibility of intravenous or intramuscular injection.

Composition

One tablet contains 150 mg of aminophylline. As auxiliary substances, calcium stearate and potato starch are used.

Dosage forms

• Eufillin is sold as tablets packed in a cardboard box. The average price for 30 pcs.is 20 rubles.
• Euphyllin in ampoules( solution for injections( 5 ml) contains eufillina - 120 mg, as an auxiliary substance is water for injections. The average price( for 10 ampoules) is 70 rubles

Next we will consider the mechanism of action of Euphyllin on the body.action of

Euphyllin is a derivative of xanthine, in fact, a bronchodilator. The pharmacological action is based on:

1. increase in accumulation in the body of cyclic adenosine monophosphate;
2. inhibition of phosphodiesterase;
3. blockingpurine receptors,
4. decrease in the intake of calcium ions through the cell membranes
5. decrease in the contractility of the smooth muscle
6. relaxation of the musculature of the bronchi
7. increase in mucociliary clearance
8. stimulation of the contractions of the diaphragm
9. improve the function of the respiratory muscles

Also the drug has the following properties:

• Euphyllin possessesstimulating effect on the respiratory center, since it is capable of increasing sensitivity to carbon dioxide and improving the ventilation of alveel, which reduces the severity and frequency of episodes of apnea.
• The drug normalizes the respiratory function, because it helps to saturate the blood with oxygen and reduce the concentration of carbon dioxide in it.
• The stimulating effect on the cardiac muscle was also revealed: the drug increases the strength and number of contractions, improves blood flow in the coronary arteries, lowers the tone of the vessels. Also, Eufillin reduces thrombosis, increases the acidity of the gastric secretion.
• Large doses also have an enileptogenic effect.

Farmakodinamika

Euphillin is able to enhance the relaxation of the bronchi and reduce the swelling of the mucosa, achieved with the administration of terbutaline and salbutamol. Do not drink Eufillin with beta-blockers, as this can lead to bronchospasm.

Pharmacokinetics

After intake, Eufillin is absorbed with a bioavailability of 90-100%.Absorption rate decreases with food intake, but the value remains constant. Action of Euphyllin is intensified by cimetidine, Erythromycin, oral contraceptives and influenza vaccine, while its concentration in the blood increases. The concentration decreases with simultaneous reception of nicotine, carbamazepine, phenytoin, rifampicin.

Indications for use of Euphyllin are discussed below.

Indications

The use of Eufillin is indicated in bronchoobstructive syndrome, for example, with:

1. bronchial asthma;
2. COPD;
3. with emphysema;
4. chronic obstructive bronchitis;
5. pulmonary hypertension;
6. "pulmonary" heart;
7. nighttime apnea.

Important to know:

• The use of Euphyllin in pregnancy is only indicated when the expected benefit from it exceeds the risk of exposure to the embryo.
• Children under 3 years of age should not be given a drug.
• At the time of taking the drug, it is necessary to stop lactation.

Instructions for use

Eufillin ingested:

• Adults. For 150 mg 1-3 r.per day. The maximum dose is 0.5 g( single) and 1.5 g( daily).
• for children. Calculation of 7-10 mg / kg per day, dividing by 4 admission. The maximum dose is 7 mg / kg( single dose) and 15 mg / kg( daily).

The course is determined by the course of the disease and tolerability of the drug, can range from several days to several months.

Contraindications

The main contraindication to taking Euphyllin can be called hypersensitivity to the main active substance of the drug and the xanthine derivative. It is also not recommended to take the drug to people with:

1. epilepsy;
2. peptic ulcer;
3. gastritis with increased acidity;
4. by hypotension;
5. tachyarrhythmia;
6. hemorrhagic stroke;
7. by a retinal hemorrhage;

Caution should be given to taking medication for people suffering from:

1. with coronary insufficiency;
2. hypertrophic cardiomyopathy;
3. by ventricular extrasystole;
4. increased convulsive readiness;
5. with renal or hepatic insufficiency;
6. by uncontrolled hypothyroidism;
7. by hyperplasia of the prostate;
8. in the elderly and children.

Usually, in these cases, it is recommended to take Eufillin together with anticoagulants.

Side effects of Euphillin

The most common side effects that mostly occur in an overdose are dizziness and headaches, anxiety and irritability, insomnia, agitation and tremors. Also, the drug may cause:

1. tachycardia;
2. arrhythmia;
3. cardialgia;
4. decrease in blood pressure;
5. skin rash;
6. fever;
7. pain in the chest;
8. albuminuria;
9. hematuria;
10. increased diuresis;
11. increased sweating;

Special instructions

Euphillin can lead to an increase in the level of uric acid in the urine. During use, care should be taken when consuming significant amounts of caffeine-containing foods and beverages.

Reviews

After analyzing the reviews, we can note their positivity. Patients claim that Eufillin perfectly removes bronchospasm, improves overall health.

The only negative point, noted by most patients, is the number of side effects, as well as an unpleasant taste. Therefore, when using the drug, it is necessary to strictly follow the dosage and prescriptions of the doctor.

Analogues

Eufillina has structural analogues that contain the same active substance. To such analogs it is possible to carry:

• Aminofillin.
• Aminophylline-Eskom.
• A solution of Euphyllin for injection is 2.4%.
• Eufillin-Darnitsa.
• Solution of Euphyllin for injection 24%.