Alcohol is a tricky thing. With uncontrolled use, this invariable attribute of all festive feasts and corporate parties becomes the cause of a serious illness that is difficult to correct - alcoholism. It is known that with excessive use of alcoholic beverages, the liver is primarily destroyed. Therefore, in the treatment of alcohol dependence, the restoration of this vital organ is of paramount importance. For these purposes, narcologists use a new drug - Metadoxil.
Description of the drug Metadoxil
Metadoxil is a medical preparation for the treatment of chronic alcoholism and the support of liver function. It has hepatoprotective properties, helps to relieve hangover syndrome, reduce cravings for alcohol. Produced in Italy by the pharmaceutical company CSC - LAB.BALDACCI.In pharmacies Metadoxil is presented in the form of tablets of 30 pieces per pack, or in the form of ampoules for intravenous and intramuscular injection. In one package there are 10 ampoules of dark glass 5 ml each.solution in each.
The active ingredient of Metadoxil is a methadoxine, a more potent pyridoxine derivative known as vitamin B6.One tablet contains 500 mg of metadoxine, microcrystalline cellulose, magnesium stearate. Ampoules for injection contain 300 mg of metadoxine and auxiliary substances - sodium metabisulphite, sodium edetate, methyl-p-hydroxybenzoate, water for injection. Tablets have a round shape, convex on both sides, color - white, on one side have a risk, on the other - engraving with the name of the drug. Ampoules contain a clear liquid that looks almost colorless or with a slight yellowish tinge.
Pharmacological properties of
Metadoxil has the property of purifying the body of toxins caused by the action of constituents of alcohol, in other words has the effect of detoxification. This is due to the activation of liver enzymes, which are directly involved in the processing of ethanol. The active substance metadoxine protects the liver from the formation of fibronectin and collagen, eliminates the accumulation of triglycerides in hepatocytes, which significantly reduces the risk of rapid decay of the liver. Due to the rapid elimination of alcohol decay products, the patient's neuropsychic state improves, the activity increases, withdrawal and anxiety go away.
It is acceptable to use the drug to avoid the appearance of hangover syndrome, that is, withdrawal symptoms. In addition to improving overall health, the drug at such times relieves the patient's increased cravings for repeated use of alcohol.
Pharmacodynamics of metadoxil is due to its pharmacological properties.
Pharmacokinetics
The drug is rapidly absorbed when ingested. Has high bioavailability - 60-80%.Long circulates in the blood, found in the blood plasma for 8 hours with any method of administration. It is excreted by the kidneys and intestines for 96 hours.
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Indications
In general, the drug is indicated for use by persons who have alcohol dependence.
Used in the following conditions:
- acute alcohol poisoning;
- toxic damage due to excessive consumption of ethanol;
- chronic alcoholism;
- hangover syndrome of any severity;
- prophylaxis of cirrhosis of the liver;
- reduced dependence on the use of alcoholic beverages.
Instruction for use
In acute alcohol intoxication, the drug in ampoules is predominantly used. The patient is administered 5-10 ml intramuscularly or 5-15 ml in the form of a dropper intravenously. The dosage and method of administration are determined by the physician. With intravenous administration, the desired dose is diluted in 500 ml of isotonic sodium chloride solution or 5% glucose solution and injected into the drip for an hour and a half.
In case of liver damage and to prevent the development of cirrhosis due to chronic alcohol abuse, the drug is prescribed in tablets 1x2 times a day. The medicine is consumed before meals. If necessary, tablets can be taken up to three times a day.
If the doctor prescribes the administration of an intramuscular solution of Metadoxil, the dosage is 5 ml of the drug per day.
The duration of treatment should be about three months. The abstinence syndrome is removed by intravenous injection of the drug solution.15 ml of the drug are diluted in isotonic sodium chloride solution or in glucose solution, as mentioned above. The solution is administered drip once a day and is given depending on the severity of the withdrawal.
Contraindications
Do not use the drug in Parkinson's disease, as it reduces the effectiveness of the medications taken with this disease.
Side effects of
No serious side effects were observed with the use of the drug. One should only fear the occurrence or strengthening of bronchospasm in persons suffering from bronchial asthma when using a solution.
Reviews
At specialized forums of alcohol-dependent people you can meet a dual opinion about the drug. Here's what one of those who want to quit taking alcohol writes: "... I started taking the pill right after the end of the encoding. While there is no craving for drinking. I'm going to take it further. "
Another anonymous alcoholic of a similar forum with great skepticism refers to Metadoxil:". .. nothing but recovery and protection of the liver is an expensive medicine you will not get. Another divorce for money. ยป
Practicing doctors-narcologists unequivocally recommend this drug in complex treatment of alcoholism, based on the conducted studies, which proved its effectiveness as hepatoprotector and neuroprotector.
Analogues and prices
Given the fairly high cost of the drug Metadoxil, and its average price in Russia is 1100 rubles.for 10 ampoules or 1400 rubles.for 30 tablets, patients of drug treatment clinics are wondering whether there are more affordable similar drugs. Among the most common drugs for the treatment of alcohol dependence, there are Lidevin tablets, but they have much more protiposages, and drops for the treatment of chronic alcoholism Colme. The drug Colme is very expensive and is not a hepatoprotector, like Metadoxil. Therefore, it is safe to say that there are no such analogs of Metadoxil.