In order to determine the patient's pancreatitis, he is sent for the delivery of various tests, including blood and urine. The submitted samples are subjected to a general and biochemical analysis, and they look at how much the obtained indicators deviate from the norm, check for the presence of unusual chemicals for the state, for example, such as bilirubin.
During the exchange of bilirubin, the formation of bile pigments occurs, which should not be contained in the urine. If bile pigments are found in the urine, then this will be indicated on the form of the results of the analysis in the part where it is said about the chemical properties of urine. One of the reasons may be a mechanical interference with the outflow of bile( obstruction of the biliary tree).
Often the concentration of bilirubin increases with an increase in the size of the head of the pancreas. In the composition of the blood, it is in two states: a) bound;b) unbound. In the first state, an increase in its volume occurs due to a decrease in the reverse entry or excretion of pigment into serum from hepatocytes, which is often found in mechanical jaundice. In this case, depending on the duration and severity of jaundice caused by pancreatitis, the level of this protein will correlate. Jaundice in patients with pancreatitis, with proper treatment, is very unstable and after a few days, its symptoms decrease. The same applies to the level of bilirubin. The high content of unbound pigment is characteristic for problems with binding, seizure, or its high pancreas production.
When it comes to the common bilirubin in the blood, we talk about the total value of its direct and indirect index. Normally, the pigment will be 1.7-20.5 μmol / l, of which about 25% are directly attached.
As already mentioned, the pigment in the blood occurs both in bound and unbound states, and in the urine unbound bilirubin should not fall, because it does not pass the renal filters, and therefore, should not be excreted in the urine. Therefore, in pancreatic disorders associated with problems of secretory function, such as pancreatitis / cancerous tumors, direct bilirubin can appear in the urine in large amounts. If urine turns indirect pigment, it means that along with pancreatitis, the patient has damage to the kidney filter, which allows him to excrete in the urine.