Studies have shown that the drug is able to effectively lower the pressure. Long-term use reduces the risk of stroke and reduces the risk of death from cardiovascular problems. About the instructions for use and indications for taking the drug Felodipine( Felodip), its price, analogues and reviews about it we will talk in this material.
Features of the preparation
The product has a mechanism of continuous action. The tablets are coated. Patients tolerate therapy with felodipine.
In case of significant discomfort in the functioning of the liver, the dose is carefully selected, the drug is administered with caution.
Composition
Substance: felodipine. Auxiliary ingredients:
- povidone,
- yellow iron oxide,
- lactose monohydrate,
- propylene glycol,
- microcrystalline glucose,
- talc,
- magnesium stearate,
- hypromellose,
- red iron oxide,
- propyl,
- titania,
- colloidal silicon.
Dosage forms
The product is available in tablet form. In one package there are 30 tablets. They have the form of lentils and are covered with a shell.
A preparation with the main substance content is produced( average package price is given):
- 10 mg - 820 ÷ 918 rub.,
- 5 mg - 510 ÷ 560 rub.,
- 2.5 mg - 430 ÷ 475 rub.
Pharmacological action
- The main active substance has the property of blocking calcium channels.
- An obstacle is created to increase pressure through the action on the vessel walls and decrease the resistance of the vascular bed.
- The preparation has almost no effect on the conductive system. The contractions of the heart do not diminish their strength.
- The decrease in pressure is due to the decrease in the resistance of the vessels at the periphery.
- An anti-ischemic effect is created. With reperfusion, the drug protects the heart from possible complications.
- Has a positive effect on myocardial infarction, reducing its size.
Pharmacodynamics
In addition to antihypertensive action, the drug also has a number of useful effects on the body:
- natriuretic effect of - promotes the production of a peptide that affects the decrease in sodium concentration in the channel, is involved in the regulation of blood pressure;
- antianginal action of - means that it helps with angina pectoris;
- diuretic action - Displays excess fluid.
Anti-ischemic action occurs in connection with the effect of the expansion of coronary vessels, improvement of oxygen supply to the myocardium. The diuretic effect is obtained because the conditions for reabsorption of sodium deteriorate, which creates the prerequisites for excluding the delay of excess fluid.
For prevention and treatment of cardiovascular diseases, our readers advise the drug "NORMALIFE".This is a natural remedy that affects the cause of the disease, completely preventing the risk of getting a heart attack or stroke. NORMALIFE has no contraindications and begins to act within a few hours after its use. The effectiveness and safety of the drug has been repeatedly proven by clinical studies and long-term therapeutic experience.
The opinion of doctors. .. & gt; & gt;
Pharmacokinetics
The absorption of the drug occurs in the digestive system. Felodipine is found in the blood plasma throughout the day. This effect is due to the peculiarity of the tablet to release the substance with deceleration.
In turn, the absorption has a prolongation, and therefore the presence of felodipine is maintained in the plasma. From the total amount of the drug consumed to the destination in the body, to create a therapeutic effect, 15% of the substance is ingested. Assimilation of the ingredients of the drug occurs in the liver.
The half-life of the basic substance is 25 hours. A half percent is outputted with urine, the substance remains unchanged.
The rest is excreted as metabolites:
- 70% with urine,
- with feces - what's left.
Indications
The drug should be taken with such diseases:
- angina,
- hypertension,
- angina of Prinzmetal.
The agent should not be taken in cases:
- of pregnancy,
- the patient does not reach the age of 18 years.
On how to take felodip, read below.
Instructions for use Felodipa( Felodipine)
Tablets are taken without violating their integrity. They should be swallowed with water( half a cup). The dose of the drug at the reception is determined by a specialist.
For the reception of pills, felodip is chosen morning time. It is allowed to do this after a small breakfast or before eating.
- For angina pectoris, the following guidelines are recommended. Treatment begins with a one-time dose of 5 mg per day, unless otherwise indicated by the doctor. Within 24 hours the amount of active substance taken should not exceed 20 mg. If necessary, then a single dose can be increased to 10 mg. With violations in the functioning of the liver - a single dose is reduced to 2.5 mg. In the case of diseased kidneys, dose adjustment is not done.
- At elevated pressure, it is recommended to take the drug as follows. For the initial dose in old age take 2.5 mg, at a younger age you can start with a single dose of 5 mg. It is taken once a day. The amount of taking the drug can change the attending physician, should consult with him before the start of the course. The maintenance dose is usually 5-10 mg per 24 hours. Instead of increasing the single dose, you can add another drug of similar effect.
For contraindications to felodipine( felodipine), read below.
Contraindications
No prescription if the patient has:
- heart failure during decompensation period,
- unstable angina,
- intolerance of any constituent of the drug,
- myocardial infarction - a period lasting a month after the disease,
- myocardial infarction in the acute stage,
- severe aortic stenosis,
- breastfeeding,
- cardiogenic shock,
- arterial hypotension of pronounced character.
Side effects of
Taking the drug may trigger such phenomena:
- fatigue,
- facial redness,
- allergic reactions in the form of rashes,
- heartbeat, peripheral edema, heart rhythm disturbance;
- headache,
- ankle edema,
- abdominal pain, nausea;
- dizziness,
- seldom there is an increased excretion of fluid from the body with urine,
- pain in the muscles and bones( infrequently),
- sexual disorders,
- sometimes liver enzymes become more active.
In most cases, adverse events may manifest themselves at the beginning of the treatment course or if an increase in dose occurs.
Special instructions
- When treating the drug, you must stop taking the juice from the grapefruit. The combination of the drug felodip and juice increases the concentration of the first in the blood.
- If the patient has severe disorders in the operation of the left ventricle, then the purpose of the drug for its treatment should be done with extreme caution.
- At the moment when the dose is being selected for admission, it is necessary to keep the pulse rate and blood pressure in the field of attention.
- During the treatment should abandon the activities associated with the need to be in the focus and respond quickly.
- The preparation, as well as other means of such action, can greatly reduce the pressure. In some patients, this situation initiates myocardial ischemia.
Reviews
- Users note the effectiveness of the drug. Successfully lowers blood pressure and improves the condition with angina.
- Some patients describe that at the initial stage of treatment there was discomfort from the fact that blood pressure fell sharply. After about a week, this effect disappeared.
- Patients' comments on the use of the drug are mostly positive. There are cases of refusal to use the drug, due to the fact that side effects have developed.
- It is described that after taking the medication the head ceased to hurt, although before that there were chronic pains of an inexplicable nature. Another patient points out that the unexpected effect was an increase in working capacity.
Analogues
Preparations in which felodipine is used as the main substance:
- retention of felotenes,
- was captured by ,
- felodipine-C3.