Being one of the most effective modern drugs with antihistamine action, Histaphen copes with a variety of allergic manifestations, reducing the degree of skin resistance and restoring its structure in the lesions. Gistafen is offered in pharmacies in various dosage forms, which makes it possible to choose the most convenient option for its use. With a high degree of efficacy, the agent in question is quite affordable, for this reason, it refers today to the most popular antihistamines.
Quickly absorbed in the gastrointestinal tract, Histafen cope even with multiple manifestations of allergic diseases, eliminating the most unpleasant symptoms for the patient. In order to obtain a more rapid positive result, it is recommended to undergo a doctor's examination before starting to use it and, after carrying out the necessary laboratory tests, to draw up an adequate treatment regimen.
Features of the preparation
Having the Latin name Histafen, Histafen has a multicomponent composition, which in many respects predetermines the high effectiveness of treatment of allergic manifestations even in the advanced stage. Withdrawal of itching, burning of the skin, which are most typical for such lesions, as well as stabilization of the general condition of the patient( elimination of fever, restoration of the microflora of the skin) - the first manifestations of the action of Histafen.
Simple application, a lot of positive feedback and high impact efficiency are the most important advantages of the medicine in question, which is used to eliminate allergic manifestations. A relatively small number of possible side effects allows it to be used to treat people with increased sensitivity of the skin, as well as to eliminate allergies in the elderly.
Histaphene is sold only in pharmacies, a doctor's prescription is required to purchase it, which can be obtained after passing the required examination and with the final confirmation of the diagnosis. Control of the doctor in the process of treatment for adults is also desirable, in a timely manner to make the necessary adjustments and accelerate the process of eliminating the most unpleasant manifestations of allergies.
Dosage Forms
For sale, Histaphen is available in the form of tablets that have a white color, an elongated oval shape. There are tablets in a polymer blister for 10 pieces in each.
The cardboard package contains also detailed instructions for use, which makes it possible to study the features of the composition of the preparation, its quality and recommendations for use. One pack can contain 10,20 and 30 tablets( 1, 2 or 3 blisters respectively).
Composition of Histaphane
The active ingredient of Histafen is the substance of sephifenadine hydrochloride, which shows increased activity to serotonin, the level of which increases significantly when an allergic reaction of the body occurs. Also included in the Histaphen tablets are the following components:
- microcrystalline cellulose;
- lactose monohydrate;
- magnesium stearate;
- cornstarch;
- silicon dioxide.
This multi-component causes a high degree of effectiveness of the drug Histafen, and the stability of the therapeutic effect ensures a long-term preservation of a positive result. The drug reaches its maximum activity after 30-40 minutes from the moment of taking the tablets, at which point the active substance reaches its maximum in the blood plasma.
Price
The value indicator can be considered one of the most important factors determining the level of demand. Gistafen, depending on the number of tablets in the package can be bought without any problems in almost any pharmacy in the city at a price of 420 to 650 rubles per package.
Pharmacological action of
This drug is one of the most active blockers of H1-receptors, which are responsible for manifestations of the most vivid allergic reactions of the body - skin flushing, manifested due to increased blood supply to the blood vessels of the epidermis, swelling of the skin, manifestations of pain and itching of the skin.
Pharmacodynamics
The drug reaches its highest concentration in the blood plasma and bone marrow tissues 12 hours after taking the Histafen tablets. Accumulation of the active substance in the body is not noted, the process of excretion begins after 25-30 hours from the beginning of the disintegration of the drug inside the body.
Due to this drug there is a significant decrease in the level of serotonin in the tissues, which provides removal of the main symptoms of allergies. However, the degree of exposure and blocking of serotonin receptors with the administration of Histafen is insignificant, and the decrease in the activity of H1 receptors is observed to a greater degree.
Pharmacokinetics
The disintegration of the drug is accompanied by the formation of inactive metabolites, which are gradually eliminated from the tissues of the body. The kidneys and intestines respond to the elimination process, the liquid fraction is excreted by urine, the solid fraction is excreted by feces.
This antihistamine drug has a positive effect on the immune response of the body. The gradual stabilization of the blood pressure level is noted, the manifestations of puffiness of the skin are removed, the intensity of itching and burning of the skin decreases.
Indications
For use, Gistafen is prescribed for the following diseases and pathological conditions:
- for allergic diseases of a systemic nature - with hives, allergic renite and dermatoses. In these cases, comprehensive treatment is recommended to increase the degree of effectiveness of the therapeutic effect;
- lesions of various genesis, in which the appearance of skin itching, soreness of the skin;
- for the prevention of infectious lesions of the gastrointestinal tract.
In dermatology, the drug Histafen showed the best results in the process of eliminating the most characteristic manifestations of allergic reactions of the body. An integrated approach is more effective because there is no reduction in the degree of therapeutic effect of the active substance of the drug when used in conjunction with other medicinal products.
Instructions for use
Presented as tablets, Histaphen cope with allergic manifestations of any nature of occurrence. Instructions for using this tool are simple. However, there are a number of differences in the use of the drug in adulthood and childhood - the dosage of Histafen is lowered in the treatment of children due to the increased sensitivity of the child's organism to the active substance of the drug.
To obtain a pronounced curative effect, the following instructions for this drug should be observed:
- Histophenic tablets are taken after meals, and should be washed with plenty of water.
- Dosage is 50-150 mg per day depending on the age of the patient.
- treatment duration is from 10 to 15 days, a noticeable manifestation of the improvement of the condition is noted after 3 days of taking the drug.
This medication can also be used for preventive action before the season of allergic manifestations, the beginning of the intake - 2 weeks before the start of the supposed negative impact.
Adult
For adults, the drug intake is usually 100-150 mg per day. Dosage is determined by the attending physician, taking into account the individual characteristics of the organism and the degree of neglect of the pathological process.
Reception of Histafen as a prophylactic is carried out on 2 tablets a day.
For infants and children
Children should be more careful when using Histafen. On average, the daily dose for children older than 8 years is 50 mg, if necessary, the dose can be increased to 100 mg per day. However, treatment should be done by a doctor and, if necessary, corrections can be made to it.
During the neonatal period, Histaphene is not recommended.
When pregnant and lactating
When bearing a child, the drug can be used in the absence of a pronounced allergic reaction from the body of a pregnant woman. Control by the attending physician in this case is mandatory.
Active substance does not penetrate into breast milk, because Histafen can be used in the treatment and prevention of allergic manifestations.
Contraindications
Contraindications include increased sensitivity to the constituent components of the drug, increased symptoms of the current lesion and failure of the kidneys and liver.
Side effects of
As side effects, the following symptoms may occur:
- dry mouth, loss of sensation to taste of food;
- nausea, eructation, urge to vomit;
- flatulence and bloating;
- increased frequency of urination.
Special instructions
- Elderly people should take Histophen while under the supervision of the attending physician to avoid amplification of allergy symptoms.
- In case of an overdose, the product should clean the stomach, take activated charcoal.
Interaction with other drugs and alcohol
- Because of the low activity with respect to other drugs, there is the possibility of using Histafen in complex therapy to obtain a greater effect.
- Alcohol intake is contraindicated due to a decrease in the absorption of the active ingredient of the mucosa by the intestine.
Reviews
- Positive feedback on the effectiveness of ongoing treatment for allergies and the removal of the most obvious manifestations of this condition indicate a high level of interest from buyers to Gistafen.
- An additional advantage of the tool is its availability of value.
- Many note as an advantage over analogues the possibility of prescribing Histafen in complex therapy.
Analogs
Gestafen analogs include Telfast preparations, Lauratec. Allergy and such drugs as Loratadine, Erius, Diazolin, Fenkarol, Claridol, Ebastin are also good at dealing with allergies.
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