Inexpensive, but effective Enam, a drug from Vidal and some others, is an ACE inhibitor. This antihypertensive agent is very popular with our compatriots. And today, we will try to understand the reason for this, having thoroughly studied the instructions and indications for the application of Enam, the price in the pharmacies for the drug, the reviews of doctors, patients and its analogs in this article.
Features of the preparation
Enam is an inhibitor of the angiotensin-converting enzyme. It is also known as Enalapril Maleate( by name of active substance).
The closest analogue of a drug is Enalapril.
Composition
As mentioned, the main active ingredient of this product is enalapril maleate, each tablet( 2.5 mg) of Enam contains 2.5 mg of it. As ancillary, the medicament includes:
- anhydrous lactose;
- zinc stearate and
- maleic acid.
Forms of preparation
Enam is available to the consumer in the form of round tablets of white color with the designation "EMT" on one of the sides, as well as figures indicating the mass of the drug( this can be 2.5, 5, 10 or 20).
Packed in contour cells( 10 packs) in cardboard boxes, 2 blisters each. In pharmacies the cost of the drug starts at 23 rubles.
Pharmacological action of
Enam is an inhibitor of the angiotensin-converting enzyme. Has hypotensive effect.
Pharmacodynamics
- The drug has an antihypertensive effect, acts depressantly on the angiotensin-converting enzyme, which in turn reduces the formation of angiotensin II, inhibits its enalaprilate.
- Lowers blood pressure in patients, has an easy diuretic effect.
- Also, like Nitromint, it reduces preload and afterload on the heart muscle in case of heart failure.
- It is able to normalize blood circulation in the vessels of the kidneys and a small circle.
The duration of its action is from half a day to a day( 12-24 hours).
For prevention and treatment of cardiovascular diseases, our readers advise the drug "NORMALIFE".This is a natural remedy that affects the cause of the disease, completely preventing the risk of getting a heart attack or stroke. NORMALIFE has no contraindications and begins to act within a few hours after its use. The effectiveness and safety of the drug has been repeatedly proven by clinical studies and long-term therapeutic experience.
The opinion of doctors. .. & gt; & gt;
Pharmacokinetics
- Absorption and distribution. Orally taken, the drug is quickly and completely absorbed from the digestive tract. High bioavailability of the drug is noted( from 53 to 74%).The achievement of Cmax in plasma occurs 3-4 hours later. The connection with plasma proteins is 50%.
- Metabolism and excretion. It occurs in the liver, and the direct excretion of the medicine occurs through the kidneys( by 60%) and the intestines( about 33%).Please note that a small amount of the substance can enter the breast milk.
Next we will talk about the pressure at which Enam is taken, and what else the tablets will help according to the instructions for use.
Indications
Application of medication Enam is indicated in such cases:
- Enam is prescribed to patients for the treatment of various forms of hypertension, including reninovascular and essential hypertension. As an auxiliary preparation, it can be used in combination therapy of CHF.
- For preventive purposes, Enam is consumed with severe heart failure, as well as coronary ischemia in people with reduced left ventricular function.
Women "in the position" as well as nursing mothers taking medication is contraindicated.
Instructions for the use of Enam
tablets Regardless of the time of ingestion, Enam is consumed orally according to the following scheme:
- To people who do not receive diuretics. The starting dosage is 5 mg per day, followed by individual selection of the norm( usually prescribed from 10 to 40 mg of the drug per day).
- People receiving diuretics. The starting dose for the inability to cancel diuretics is 2.5 mg.
- CHF. The initial dose is similar to the previous dose( 2.5 mg) per day, while it is important to keep an eye on the pressure. After the doctor usually appoints the drug twice daily for 2.5 mg for three to four days. After the first 7 days of admission, the dosage is increased to 10 mg once a day. At the onset of 3-4 weeks, the dose can be 20 mg( 1 or 2 times a day) with systole.pressure of not less than 100 mm. Hg.
Contraindications
Complete ban on taking
As with other medications, the drug is contraindicated for those who are hypersensitive to one or more of its components, as well as pregnant or lactating women and children under 18 years of age.
Do not designate ENAM if the patient has:
- angioedema( due to the administration of ACE inhibitors) in the anamnesis;
- porphyria;
- stenosis( aortic, mitral).
Admission with extreme caution
In addition to categorical contraindications for the reception of Enam, there are also cases when it should be taken with caution. Such cases include:
- hypovolemia;
- IHD;
- heart failure;
- stenosis of the arteries of the kidneys;
- problems with cerebral blood flow;
- problems with water-salt balance.
Side effects
- Respiratory system: pharyngitis and glossitis, unproductive cough, watery discharge from the nose, shortness of breath.
- CCC: bradycardia and tachycardia, myocardial infarction, angina pectoris.
- GASTROINTESTINAL: problems with stool and digestion, pancreatitis, nausea, dry mouth, loss of appetite, intestinal obstruction, and others.
- CNS: depressive state, headaches, insomnia, tinnitus, loss of consciousness.
- System of hematopoiesis: hypoglycemia, decrease in leukocyte count, hemoglobin, as well as hematocrit, potassium and bilirubin increase, neutropenia.
- Allergic reactions: bronchospasm, urticaria.
- Reproductive system: problems with erection.
It is also possible to develop a sympathetic complex consisting of hyperemia, eosinophilia, vasculitis, and joint pain.
Special instructions
- If the patient exhibits an arterial hypotension, then it is necessary to check the electrolytes, blood pressure. The drug in this case is not abolished, but the dosage is adjusted.
- When consuming Enam during surgery, together with anesthesia often leads to hypotension.
- It is also likely an increase in the level of urea nitrogen and serum creatinine.
- The drug does not require simultaneous reception with potassium-containing drugs.
- If the arterial hypotension due to an overdose of the drug patient must be laid, legs should be raised. Further, if the case is mild, the saline solution should be administered orally, or, in severe cases, intravenous saline or plasma replacement for normalizing blood pressure.
Reviews
Summing up the available testimonials of those who tried Enam on themselves, one can distinguish such characteristics:
- well reduces hypertrophy of the left ventricle, and also reduces the need for cardiac muscle in oxygen;
- negative effects on themselves were felt by people with the syndrome of malabsorption of glucose-galactose, since the composition of the drug includes lactose;
- often causes stomatitis and decreased appetite;
- at too high doses of medication causes arterial hypotension.
In general, patients note its effectiveness, and doctors prescribe the drug quite often.
Analogues
Replace the drug( as agreed with the doctor) can be using such means as:
- Enalapril, the cost of 10 rubles;
- Enalapril Hexal, at a price of 72 rubles;
- Enap, the price is from 70 rubles;
- Enalapril-FPO, the cost of 30 rubles.