An antitumor drug. Can be used only on the advice of a specialist. During the course of treatment, careful monitoring of the patient's condition( individual systems, blood) is required.
Composition, form of production and storage conditions
The preparation contains the active substance cyclophosphamide. There are no additional ingredients.
Manufacturer
Cyclophosphane is produced by JSC Biochemistry, Russia.
Indications
means assigned for use in diseases:
- liposarcoma,
- acute lymphoblastic leukemia,
- lung cancer, small cell shape,
- chronic lymphocytic leukemia,
- reticulosarcoma,
- ovarian cancer,
- Wilms tumor,
- breast cancer,
- multiple myeloma,
- Ewing tumors,
- bone reticulosarcoma,
- angiosarcoma.
Contraindications
If the patient is diagnosed with one or more of the following conditions, the drug is not prescribed:
- when the patient is in a severe stage of the disease, which is defined as a death;
- during gestation,
- if the tests showed a marked decrease in hemoglobin level in the blood,
- if the patient suffers from a viral infection in the active phase,
- for severe pathologies:
- of the kidney,
- of the heart,
- of the liver;
- if the patient is in a state of severe exhaustion,
- if the patient's body gives a negative reaction to the active substance.
Mechanism of action
Cyclophosphamide leads to destructive phenomena in the region of the cell's DNA through chemical processes initiated by the active substance of the agent. As a result, the cell loses its ability to reproduce.
Instructions for use Cyclophosphamide and dosing regimen
The drug is used as a solution intramuscularly or intravenously. The dose and mode of administration of the drug is individually prescribed by the doctor. The course is usually used from 6 to 14 g of funds.
The most commonly used regimens are:
- one intravenous procedure in two or three weeks( 2 ÷ 3 g);
- is the same, but in five days( 1 g);
- administration of the solution intramuscularly or intravenously every other day( 400 mg),
- is the same, but every day( 200 mg).
The drug is used for long-term therapy, as well as as an immunosuppressive agent.
During the course of treatment, you should observe the composition of the blood, do a blood test after 2 ÷ 3 days. It is important not to miss the moment when the decrease in leukocytes and platelets exceeds the permissible sizes.
Side effects
There may be negative consequences from the use of the drug. Cyclophosphate in some cases causes:
- disorders in liver function,
- may have problems with hematopoiesis:
- decrease in hemoglobin level,
- of the same white blood cells,
- of the same platelets;
- is a violation - hair regrowth, which differ from the usual and structure and color;
- discomfort in the digestive tract, which leads to such manifestations:
- constipation,
- nausea,
- pain in the abdomen;
- in men are possible such violations:
- testicular atrophy,
- oligospermia;
- in women there are malfunctions of the monthly cycle,
- In women of any sex, the drug can provoke sterility,
- allergic reactions:
- skin itch,
- rashes,
- urticaria;The
- preparation in some cases causes cardiotoxicity, pulmonary fibrosis.
Overdose of
If an overdose of the drug occurs, undesirable effects may appear:
- worsens the work of the bone marrow,
- urotoxic phenomena,
- changes in the composition of the blood.
You need to know that there is no special antidote.
In connection with what signs are manifested - appointments of symptomatic therapy.
Special instructions
Use with caution. With prolonged use, it can exhibit a carcinogenic effect. Incompatible treatment with the appointment of funds and the use of alcohol.
During the administration of the drug, the composition of peripheral blood should be controlled. To do this, periodically take a blood test.
Interaction
The drug can reduce the clotting factor of the blood. But sometimes an unknown mechanism works, and the effect of the drug shows the opposite result. During the intake, the use of grapefruit is excluded.
With the simultaneous use of drugs and daunorubicin or doxorubicin, cardiotoxic action is enhanced in them.
Patient feedback
Users respond well to Cyclophosphamide as a remedy that has proved effective in the complex treatment of malignant tumors. Also, good feedback on the use of the drug - its effect on the body is milder than other drugs of this direction.
It is noted that the drug assists at any stage of the disease severity.
Price
Cost of cyclophosphamide in pharmacies( in Moscow) is from 181 rubles.
Analogues of the drug
To the preparations that can be called analogues( have the same ATC code) cyclophosphamide are:
- Isole,
- cloceran,
- ifos,
- alkenean,
- holoxane.
What is better than Endoxan or Cyclophosphamide?
Endoxan and cyclophosphamide are synonymous with each other.
This designation indicates that they have the same active substance - cyclophosphamide.
The endoxane is produced in addition to the powder for the solution, also in the form of a dragee.
The manufacturer of the drug is foreign: Germany, USA, Spain.
Synonyms for the preparation
Means that are classified as synonyms for the drug:
- cyclophosphamide,
- endoxane,
- cytoxan.