Gastritis is an inflammatory disease of the gastric mucosa, often associated with the infectious agent Helicobacter pylori. Today, this pathology ranks first among GI diseases in both adults and children.
Metronidazole is a drug of the 5-nitroimidazole group. A broad-spectrum antibiotic that exhibits high therapeutic efficacy against obligate anaerobes, protozoal infections, which finds its application in gastroenterological medical practice for gastritis, especially associated with the presence of Helicobacter pylori.
Each tablet contains 250 mg of metronidazole;Starch, povidone and stearic acid are used as auxiliary ingredients.
Metronidazole with gastritis
The NO2-group of metronidazole is incorporated into the respiratory chain of bacteria and protozoa, disrupting the processes of their intracellular metabolism, which causes the death of pathogens. The effectiveness of the drug is potentiated by its ability to inhibit the replication of the DNA molecule and, as a result, the very process of reproduction and development of pathogens of a number of anaerobic obligate infections.
The drug is indicated for gastritis, associated primarily with Helicobacter pylori infection, the presence of which is determined by special laboratory tests.
In the treatment of gastritis, metronidazole is prescribed only as an additional agent in combined eradication therapy for Helicobacteriosis together with other drugs. In modern medicine, two basic 7-day regimens for treating gastritis are used: on the basis of inhibitors of H + / K + -ATPase and bismuth preparations.
- Proton Pump Blocker: Omeprazole or Lansoprazole( 20 mg and 30 mg respectively) twice daily + Clarithromycin, 250 mg twice daily with meals + Metronidazole, 500 mg twice daily with meals.
- De-nol in a dosage of 120 mg to drink 4 times daily before meals + antibiotic Tetracycline, 500 mg per 4 doses per day( either Amoxicillin or Clarithromycin, 1000 mg and 500 mg respectively, 2 times a day) + Metronidazole, 500 mg twice daily( with food).
Metronidazole and Amoxicillin in the treatment of gastritis
Amoxicillin is an antibiotic agent related to semisynthetic penicillins of a wide range of action. The mechanism of its pharmacological action is a violation of the synthesis of the phospholipid bacterial cell wall. Amoxicillin is indicated for gastritis associated with Helicobacteriosis, therefore it is often prescribed in complex therapy along with Metronidazole, which mutually reinforces their effect. In addition, with such a scheme, the probability of antibiotic resistance( resistance) of pathogenic microorganisms to both drugs is significantly reduced.
With gastritis, Amoxicillin is prescribed to drink together with Metronidazole in a daily dosage of 1.5-2 g( based on 2 doses).If necessary, the doctor responsible for the patient can make changes in the course of treatment, depending on the patient's condition, the effectiveness of therapy, etc.
Metronidazole and Amoxicillin for gastritis against a background of Helicobacter pylori infection form one of the most sought after treatment regimens. But in order for their therapeutic effect to be most effective, one should take into account the severity of the disease, its duration, the presence of concomitant pathologies - all this can be assessed only by a specialist who, accordingly, will prescribe the correct treatment.