Medicinal antiulcer Omez prescribed for gastritis with high acidity, peptic ulcer. Take this drug for a long time, without interruptions for holidays and weekends, which raises questions about whether it is possible to take the medicine simultaneously with alcohol.
Principle of the drug Omez
Omese is an inhibitor of the proton pump, a remedy that reduces the acidity of gastric juice. The active substance of the drug - omeprazole, exhibits antiulcer, antisecretory effect.
Mechanism of action
Omeprazole blocks the formation of hydrochloric acid in the stomach, acting on the enzyme H + / K + - ATPase. The drug is absorbed in the small intestine, enters the liver with blood, then penetrates into the mucous cells of the stomach, accumulating in the secretory tubules.
With increased acidity, omeprazole binds to the enzyme H + / K + - ATPase, blocking its work, stopping the production of acid. This interaction between the drug and the enzyme is irreversible. To renew the tubule activity, it is necessary to renew the enzyme, synthesize a new molecule of H + / K + - ATPase.
It takes about 2 days to resume the secretion of hydrochloric acid. During this time, the acid concentration decreases.
Pharmacokinetics
Omeprazole is rapidly absorbed, penetrates into the cells of the stomach after 0.5-3.5 hours. The half-life period is 1 hour, with liver diseases it is absorbed more slowly, the half-life period lasts up to 3 hours.
Indications, contraindications
Omega is prescribed for the treatment of gastric ulcers, reflux esophagitis, erosive diseases of the duodenum.
The risk of hypomagnesemia increases with the simultaneous use of diuretics - diuretics. Ethyl alcohol has a diuretic effect, when used with Omega it can reduce the concentration of magnesium in the body.
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Taking drugs whose action is based on blocking the proton pump increases the likelihood of senile dementia in old age.
Side effects of
Admission Omeza is able to affect:
- on the nervous system, with the appearance of dizziness, drowsiness, disturbance of night sleep, development of depression, arousal;
- on the digestive tract, with the occurrence of stomach pain, diarrhea, constipation;
- on the musculoskeletal system, contributing to the appearance of muscle weakness, pain in the muscles, joints.
On the video review of the drug Omez:
Drug compatibility with alcohol
Metabolism of omeza and alcohol is carried out by the same enzyme system, which increases the load on the liver.
The frequent effects resulting from the compatibility of these substances include:
- nausea, vomiting;
- disorder of stools;
- headache;
- allergy;
- is a nervous stimulation.
The mutual influence of the drug and ethyl alcohol is manifested by increased signs of intoxication. In addition, the intake of alcohol causes the release of hydrochloric acid, acting in the opposite way to the drug, the reception of which reduces the synthesis of the acid. Alcohol reduces the concentration of the drug, reducing the effectiveness of treatment.
Possible consequences
Simultaneous reception of omeza with alcohol:
- enhances the intensity and duration of intoxication;
- worsens the liver, provoking the development of hepatitis;
- increases the acidity of the stomach, reducing the effectiveness of treatment;
- enhances the side effects of the drug.
The effects of taking Omez at the same time as alcohol include hepatic encephalopathy. The disease develops in patients with impaired liver function.
Taking the drug concomitantly with ethanol on the background of liver disease causes:
- a rapid increase in the ammonia content in the blood plasma;
- imbalance between the formation and breakdown of neurotransmitters in the brain.
Changes in internal equilibrium are expressed by clinical signs. With mild degree of hepatic encephalopathy, the patient is noted for apathy, the appearance of drowsiness, and retardation.
Disturbance of liver function under the influence of alcohol and drug can worsen the patient's condition. By combining Omez with ethanol, one can achieve confusion of consciousness, confusion in stupor - a state of mental oppression with lack of mobility, silence.
At this stage, contact with the patient is broken, if you do not help the victim, a coma may develop. The leading role in this state belongs, of course, to ethyl alcohol. Anti-ulcer drug Omez plays an auxiliary role in this process, strengthening liver failure.
Rules for taking
Omez is quickly absorbed by the body. To drink alcohol safely, do not worry about the consequences, it's enough that between the taking of this medication and ethanol took 1 hour.
Treatment of peptic ulcer disease requires compliance with the diet. No diet aimed at treating the stomach, does not include alcohol. When treating the stomach can not under any circumstances take alcohol.
Conclusions
Admission of omeza with alcohol worsens the condition with a hangover, disrupts liver function, increases intoxication, reduces the effectiveness of treatment. Ethanol destroys the stomach, causes alcoholic gastritis.
Drinking alcoholic beverages in cases of stomach diseases is contraindicated, especially with the medicine. But after drinking alcohol, there are such conditions that are treated with Omega.