Digoxin: instructions for use, price, reviews, analogs, indications

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A drug designed to help the work of the heart. The use of the product requires care and caution. Therefore, today we will tell you more about the tablet itself, its analogs, the price and reviews of Digoxin, we will review its instructions for use and side effects.

Features of the preparation

The agent is a cardiac glycoside obtained from the leaves of the digitalis. The substance is insoluble in water and alcohol.

Composition

The main substance that causes the action of the drug - digoxin. Additional ingredients of the product:

• talc,
• potato starch,
• sucrose,
• dextrose,
• lactose,
• calcium stearate.

Dosage forms

The drug is available in tablet form. One tablet contains digoxin in an amount of 250 μg.

Blister has 10 tablets. The bundle can have blisters:

• one,
• two,
• three.

There are in the pharmacy network tablets in a plastic package of 50 pieces in a jar. The average price of a package with tablets No. 30 is 38 rubles.

The drug is a cardiac glycoside. Is acting:

• antiarrhythmic,
• cardio-stimulating, affects cardiac contraction force;
• vasodilator, affects stagnant processes;
• is moderately diuretic, which helps to reduce swelling.

Pharmacodynamics

• The drug reduces sympathetic activity from excessive function to normal. The power of the heart increases.
• Myocardial tonus becomes higher, which leads to the fact that the heart muscle shrinks and its oxygen demand decreases.
• Increased myocardial force causes the property of the drug to increase the content of sodium ions in cells. This activates the sodium-calcium exchange, and the content of potassium ions decreases.
• Antiarrhythmic effect occurs through inhibition of the rate of passage of the pulse through the atrioventricular node and it is important that the refractory period is prolonged.

Pharmacokinetics

• The bioavailability of of active substance reaches 70%.Getting into the food tract, it is quickly absorbed. In plasma, a therapeutic dose is observed 1.5 hours after taking digoxin.
• The substance is excreted through the kidneys together with the urine. This process will depend on the functionality of the kidneys, the age of the patient.
• The half-life of substance in young people is up to one and a half days. In the elderly, this takes twice as long.

Now let's talk about the indications and contraindications for taking Digoxin.

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Indications for the use of the drug Digoxin

The properties of the drug make it possible to use it during the bearing of a child under the question mark. If the benefits that a woman receives will greatly prevail over the harm that the fetus feels, then the purpose of the drug makes sense. Children under three years of age do not recommend taking the remedy.

The drug is prescribed to solve problems:

• Atrial fibrillation( tachysystolic form) with the course of paroxysmal and chronic illness.
• For chronic heart failure as part of a comprehensive treatment.

For the dosage of digoxin tablets, we will explain later.

Instruction

Dose is prescribed in each case individually, taking into account all the characteristics of the patient. First, they achieve that the amount of matter in the body reaches saturation, then only maintain the therapeutic effect.

• Slow saturation of - taking the drug once a day( for about a week) in an amount of 0.125 ÷ 0.5 mg.
• Moderately fast saturation of - during the day or a half day recommend taking the drug in an amount of 0.75-1.25 mg. The dose is taken twice a day in equal parts. Before each reception, an electrocardiogram is made to monitor the condition.
• The maintenance dose of is approximately 0.25 ÷ 0.125 mg per day.

Contraindications

Assign with caution if the patient has a violation:

• myocarditis,
• impaired renal function,
• hypothyroidism,
• obesity,
• electrolyte disturbances.

Contraindications:

• intolerance of one or more ingredients of the drug,
• II degree of AV blockade,
• cardiac tamponade,
• glycosidic intoxication,
• complete impairment of atrial to ventricular transmission,
• Wolff-Parkinson-White syndrome,
• myocardial infarction.

Side effects of

Most often, the body's response to the drug is inadequate when an overdose occurs. Adverse events that may cause drug intake:

• disorders in the digestive system:
  • abdominal pain,
  • decreased appetite,
  • nausea, possibly vomiting;
  • diarrhea,
  • anorexia,
• related to sensory organs and nervous system function:
  • diplopia,
  • vision impairment,
  • sleep disorder,
  • photophobia,
  • headache,
  • fatigue,
  • flashing of flies,
  • drowsiness,
  • faintness,
  • dizziness,
  • depression,
  • psychosis,
• reactions associated with blood circulation, vascular system:
  • bradycardia,
  • cutaneous hemorrhage,
  • thrombopenia,
  • ventricular extrasystole,
  • thrombocytopenicpurpura,
  • AV blockade,
• other manifestations:
  • rash,
  • gynecomastia,
  • urticaria,
  • bowel ischemia.

Special instructions

Due to the fact that the drug in excess dose manifests itself as a toxic substance, it is important to observe the prescribed amount of the substance at the reception. Between the therapeutic dose and the dose that can cause negative manifestations, the difference is not high. Therefore, you should carefully follow the prescription and, when using the remedy in the medical process, be supervised by specialists.

If the patient has a kidney disease, then a reduction in the dose of the drug at least a quarter of the usual dosage is required. The risk of toxic effects of the drug is increased if the patient suffers from such disorders:

• hypothyroidism,
• alkalosis,
• hypercalcemia,
• pulmonary heart,
• hypomagnesemia,
• marked myocardial dilatation,
• hypernatremia.

For the control of the condition, it is necessary to periodically conduct:

• electrocardiography,
• monitoring of blood serum for the maintenance and the ratio of electrolytes:
  • calcium,
  • magnesium,
  • potassium.

Reviews

Patients taking digoxin, note that you should treat this carefully and if you have discomfort, seek the advice of a specialist. When taking an increased dose, the patient experienced hallucinations. After the drug was discontinued, the negative effect stopped.

There is a positive result in heart rhythm disturbances. Although at first it was nausea, sweating. Patients talk about a good effect in heart failure, dyspnea. It is necessary to pay very careful attention to the prescribed doses of the medicine, there are poisonings with the active substance.

Analogues

This:

• Digoxin Grindeks,
• Celanid,
• Novodigol,
• Digoxin-Health,
• Digoxin TFT.

Elena Malysheva in her program will tell you about what you should not eat when you take Digoxin: