With the diagnosis of duodenal ulcer, treatment with medicines forms the basis of conservative therapy.
Medications for duodenal ulcers are related to the following pharmacological groups:
Antisecretory drugs
Irreplaceable drugs in the treatment of duodenal ulcers. Medicines inhibit the secretion of the stomach, reducing the aggressive effect of hydrochloric acid on the defect of the mucosa of the small intestine.
The group of these drugs is not homogeneous. It consists of:
- H2 blockers( histamine-receptors): famotidine, ranitidine. Medicinal preparations reduce the dihydric acid production of the stomach by 60%, not allowing the acidic medium to erode mucous membranes of the intestine. Famotidine has the longest pharmacological effect than Ranitidine. Blockers create the most favorable environment for antibiotic therapy, making treatment aimed at killing Helicobacter pylori, the most effective.
- M1( anticholinergics): Pyrenzepine. The remedy for duodenal ulcer can reduce the amount of stomach acid and pepsin. And also to remove muscle tone. It is used as an auxiliary preparation to the basic treatment.
- Omega, Omeprazole, Zerocid are proton pump inhibitors. The newest remedy for duodenal ulcers, a single dose of which suppresses the secretory function of the stomach by 80%, reducing the daily amount of hydrochloric acid and the enzyme pepsin. The combined use of inhibitors and antibiotics most efficiently influences the bacterial infection of Helicobacter pylori, suppressing it.
Bismuth-containing preparations
De-Nol, Vikair, Vikalin, inhibit the viability of the pathogenic microorganisms Helicobacter pylori, form a protective film, preventing the aggressive attack of acid on the bowel defect.
Medications for duodenal ulcers containing bismuth, inhibiting the activity of bacteria, do not affect the properties of the juice produced by the stomach. When treated with bismuth-containing drugs, stools are stained with black.
Ranitidine( bismuth citrate) and sucralfate are complex effective remedies for duodenal ulcers, which possess an antacid, protective and suppressing Helicobacter pylori action.
Antiprotozoal and antibacterial agents
Amoxicillin, Tetracycline, Metronidazole, Trichopolum, Clacid, Tinidazole, Fazigin are prescribed to suppress the viability of Helicobacter pylori.
The drug treatment of duodenal ulcers is based on antibacterial drugs combined with antisecretory or bismuth-containing drugs. The remaining drugs play a secondary supporting role in antiulcer therapy.
Prokinetics and antacids
Motilium, Coordix, Cerucal improve the progress of food in the intestines, eliminating the feelings of nausea, preventing vomiting. Means for duodenal ulcer are prescribed when there is an overflow and heaviness in the stomach. Prokinetics are prohibited when narrowing the gastric outlet of the pylorus.
Antacids: Gastal, Almagel, Maalox, Gelyusil, Fosfalugel - symptomatic preparations that have an adsorptive and astringent effect, are taken with heartburn and pain caused by increased acidity.
Other medications for duodenal ulcer
1. Anesthetics: Ketorol, Baralgin;
2. Spasmolytics: Trigan, Atropine, Spazgan, No-shpa quickly stop pain in PDK ulcer, as excess acid provokes pain of a spastic nature;
3.Biogenic preparations that improve the nutrition of mucous membranes of the intestine: Actovegin, Solcoseryl, vitamins.