Diucifone is a complex preparation of synthetic origin, stimulating metabolic processes, immune defense of the organism and powerfully suppressing activity of pathogenic microorganisms. Today, we'll talk about whether DiSyphon's medicine helps with leprosy, what are its instructions for use, price, analogues.
Features of the preparation
The pronounced activity of Dyu-Citon is observed in relation to tubercle bacillus Koch and mycobacterium leprosy.
Initially, Dyuziphone was synthesized for the treatment of leprosy patients. Having proved its effectiveness in curing this pathology, the drug simultaneously showed high possibilities in the complex treatment of diseases that occur in violation of the basic mechanisms of immune responses such as psoriasis, tuberculosis, scleroderma, rheumatoid arthritis.
Next, we'll figure out what constitutes the active ingredient of the diucifone.
Composition of Dyuzifone
The active ingredient of Dyuziphon is a chemical compound - para-para-( 2,4-dioxo-6-methylpyrimidinyl-5-sulfonamino) -diphenylsulfone, which is derived from diaminodiaphenylsulfone in the presence of two methyluracil residues.
Dosage form
- The product is manufactured as powder , snow white or with a light cream color, odorless with little bitter taste. Crystalline powder melts at a temperature of about 235 C, soluble in water moderately, does not dissolve completely in alcohol.
- In addition, Dyuziphone is produced as ointment and 3% solution of .
Pharmacological action
Dietuconon's therapeutic activity is aimed at a powerful suppression of the growth and reproduction of pathogenic microorganisms that cause severe dermatosis.
The drug was developed as an effective remedy against leprosy, which provokes fewer negative side effects than diaphenylsulfone( DDS), and simultaneously has a stimulating effect on immune and metabolic mechanisms.
Farmakodinamika
- Practical application of Dyuzifona proved that the drug has a pronounced positive effect on immune reactivity. And the impact is simultaneously manifested at two levels: humoral and cellular.
- In the mechanism of humoral immunity, Dyuziphon normalizes the number of B-lymphocytes that recognize foreign agents, including microbes, and produce antibodies( immunoglobulins) against them.
- At the level of cellular mechanisms of immunity, Dyusiphon increases the content and activity of so-called immunocompetent cells - T-lymphocytes and phagocytes, which protect the body from viruses, fungi and cancers.
- In addition, Dyuziphone stimulates the production of IL-2, special protein compounds - cytokines that suppress the activity of Gram-negative bacteria Escherichia coli, activates the synthesis of RNA and proteins.
- The drug inhibits the multiplication of pathogenic microorganisms and massively suppresses all types of leprosy, including lepra species, which are provoked by pathogens that are not susceptible to sulfones.
- Studies have proven that Dyutiphon is almost 5 times less toxic than DDS and is much better tolerated, causing much less adverse adverse effects with long-term admission, which is typically found in sulfones.
Combining the properties of diphenylsulfone and methyluracil, Diucifone has the following effects on the body:
- accelerates the processes of tissue regeneration, granulation maturation of new connective tissue, epithelization;
- suppresses inflammation;
- stimulates the production of red blood cells and leukocytes;
- improves the trophism( cellular nutrition) of tissues;
- normalizes protein metabolism.
Pharmacokinetics
Medication is excreted slowly enough. It has the property of accumulating and shows the greatest effectiveness with a long course of use, since the therapeutic effect develops gradually.
Indications
Diuzifon is indicated for patients with tuberculoid and lepromatous forms of leprosy, tuberculosis, as well as the following pathologies:
- of dermatoses against immunodeficiency such as - severe psoriasis, sclerodemia, true eczema, pyoderma( pustular skin disease);
- herpetiform( herpetic) vesicular dermatitis of Dühring;
- infectious diseases with an allergic component leading to inflammation of the joints( rheumatoid arthritis);
- of chronic lung diseases and acute pneumonia( the result is comparable with the therapeutic effect of Levamizol and Prodigiozan).
About instructions to the medicine for leprosy and other dermatological diseases Diucifon we'll talk below.
Instructions for use
Diuzifon used in two forms - inside( in powder) or in injections( intramuscularly).
Leprosy
For leprosy apply:
- inside 4 to 5 times 100 mg per day after meals( admissible reception 2 - 3 times a day for 200 mg);
- in injections - intramuscularly once a day.
For injection, a 5% solution is prepared by pouring 200 mg of the powder from a vial of 4-5 ml of hot water( distilled).
When leprosy shows a long-term therapy, which is carried out in conjunction with other medicines. Treatment is prescribed by courses lasting up to six months with an interval of 1 month. The effectiveness of the therapy is estimated from laboratory data: bacterioscopy and histology.
Typically, the complete stagnation of the manifestations of the disease in tuberculoid leprosy is completed after 4 to 8 months( sometimes up to 12 months), with lepromatous form, improvement is observed at 8 to 10 months of treatment, and a complete cure occurs in 1 to 2 years.
Other diseases
- For the treatment of eczema, a course is needed that includes the introduction of 12 injections.
- Dermatoses require therapy according to the "intermediate" scheme: 100 - 200 mg orally 2 to 4 times a day( or 200 mg in 4 ml of a 5% solution intramuscularly) in cycles of 5 days with an interval of 1 day. The duration of the course is determined by the nature of the pathology, the severity of the disease and the tolerability of the Dyuucifone by the patient.
- In acute pneumonia, Dyuziphon is also prescribed according to a cyclic schedule: 3 days orally, 100 mg three times a day, with a break of 4 days. Duration 21 days.
- In obstructive bronchitis, the drug is prescribed in a daily dose of 300 mg in a course of 7 days.
- 6. Patients with pulmonary pathologies developing against the background of a fall in the body's immune defense( reactions to the pathogen) are prescribed 6 injections according to the schedule: 1 injection a day, then a two-day break, and one more course.
- In pediatrics, Dyuzifon is used to treat children from the age of 5 years. Assign a cyclical administration scheme - inside by 25, 50, 100 mg( depending on the patient's age and severity of the process) twice a day with a one-day interval every 6 days.
- In the form of injections, the agent is administered in a volume of 1 to 2 ml of the solution( 2.5% or 5%) every other day or every day. Course 21 - 28 days.
On whether the dose of Dyuziphone is reduced during treatment, we will describe below.
Contraindications
Diuzifon not prescribed:
- for diseases of the blood, liver, kidneys, organs of the gastrointestinal system;
- in severe form of cardiovascular pathologies;
- for organic lesions of the central nervous system
- with drug intolerance.
Side effects of
Undesirable concomitant reactions that may occur with the use of Diuzifone:
- weakness, insomnia, anorexia;
- digestive disorders;
- dizziness, headaches, transient visual impairment;
- increased frequency of myocardial contractions( tachycardia), pain in the region of the heart;
- rarely - cyanosis of the skin and mucous membranes;
- toxic inflammation of liver tissue;
- anemia( due to oppression of hematopoiesis);
- fever;
- itching, skin rash;
- neurological disorders.
If a severe adverse effect occurs, the dose is reduced or discontinued completely.
- In case of acute hepatitis, Diucifone is canceled and vitamins B12, B13, B15, C, PP, methionine, lipocaine, glucose together with cholagogue funds are prescribed against the background of the diet.
- With the development of iron deficiency anemia appoint Ferbitol, Ferrumlek, B12 and fractional blood transfusions.
Special instructions
During treatment with DYUTSIFON:
- Once a month, blood tests and urine tests are checked.
- To reduce the likelihood of adverse reactions at the same time as the drug, medications that have a positive effect on liver function - yeast, vitamin complexes with group B and PP, iron preparations are taken.
- When a serious drug overdose and the development of severe complications, glucocorticoids are used, calculating the daily dose, based on the rate of 1 mg of prednisolone per kilogram of the patient's weight.
- In severe disorders of liver and kidney functions, a decrease in the number of red blood cells to 2.5 × 1012 / l, not increasing within 15 days, the drug is canceled.
Next, reviews of doctors and patients about Diuciphone will be given.
Reviews
Reviews of patients and doctors about Diucifone are ambiguous.
For the greatest effectiveness of the drug before taking:
- accurate calculation of dosage;
- development of an individual therapy scheme, taking into account the nature and severity of the process, the age of the patient;
- use of the medication in a complex way - with other active medicines;
- inclusion of remedies eliminating unwanted reactions.
In these cases, the drug gives a positive result, curing for leprosy, dermatoses and pulmonary pathologies. If the remedy is taken on its own, there are side effects, which are the reason for negative reviews about the drug.
Analogues
Analogs for the action of medications:
- Avlussulfone,
- Dapsone( from 2 200 rub.),
- Solusulfone,
- Eporal,
- Diaphenylsulfone,
- Novophone,
- Diphenason,
- Clofazimine