Fucidin is a preparation of antibacterial action. A natural antibiotic called fusidic acid is the main active substance. The drug is widely distributed in dermatology for the treatment of infectious diseases caused by staphylococci, streptococci, and also some other types of bacteria.
Features of the drug
Pharmaceutical companies produce ointment, cream, tablets, powder and suspension under the same name - Fucidin. All of them are intended for the treatment of various diseases. The drug is recommended to buy by prescription of a treating specialist.
Dosage forms
Fucidine is manufactured in various forms:
- Ointment is sold in aluminum tubes of 15 g and is used externally. Tubes are packed in cardboard boxes.
- Cream is sold in aluminum tubes for 15 grams and is used externally. Tubes are packed in cardboard boxes.
- Tablets for oral administration are packaged in 12 pieces in a cell package. Are sold in cardboard packs.
- Suspension for oral administration is sold in glass bottles of 90 ml. The bottles are packed in cardboard boxes.
- Powder for infusion and topical application is packaged in glass bottles of 10 ml and packed in cardboard packs. To each bottle of powder futsidina attached 1 bottle of buffer solution.
Composition of Fucidin
The main active component of fucidin is fusidic acid. In each dosage form, its auxiliary substances.
Price
The price category of the drug is relatively high.
- In pharmacies of different regions it varies greatly from 342 rubles to 866 rubles.
- The average price in online pharmacies ranges from 422 rubles to 529 rubles.
Pharmacological action
Active substance of the drug Fucidin - Fusidic acid. It was introduced in the 60s of the last century into medical practice. The effect of acid has on staphylococci, streptococci, meningococci, pneumococci, gonococci.
Farmakodinamika
The action of the drug is based on the binding of antibiotic molecules to the ribosome of the bacterium and on the suppression in the cell of the bacterium of protein biosynthesis. This process provokes the destruction of pathogenic bacteria at the intracellular level.
The toxicity of a natural antibiotic is low. The acid is not active against fungi, E. coli, protozoa, salmonella.
Pharmacokinetics
With external application, Fucidine practically does not penetrate into the bloodstream, as only about 2% of the drug is absorbed into the skin. Fusidic acid is excreted from the body mainly with bile, in part - with urine.
Indications
Fucidine in the form of a cream or ointment is prescribed for the treatment of skin infections, including:
- of furunculosis
- carbuncle disease
- impetigo( streptodermia, staphylodermia)
- acne vulgaris
- infected wounds
- purulent inflammation of apocrine sweat glands( hydrangea)
- purulent inflammation of the hairfollicles and sycosis of the beard
- pseudo-fungal infections
- inflammation of the peri-oral roller
Fucidine in the form of tablets, suspension or powder for the preparation of lyophilizate(
Fucidin powder is used topically for eye diseases such as:
- conjunctivitis
- keratitis
- infections caused by removal of a foreign body from the eye
- barley
- inflammation of the lacrimal sac( dacryocystitis)
- inflammation of the eyelid edges bilateral( blepharitis)
Instruction for use
Fucidine has several advantages over other drugs with a similar effect,apply even for newborns. Use it in accordance with the instructions.
Adult
Ointment or cream treat affected skin areas up to 4 times a day. Pre-skin should be cleaned of excreta and pus, then apply the drug in a thin layer. If you use a gauze dressing, then the number of daily treatments can be reduced to two times a day. The usual course of treatment is 1 week. In exceptional cases, the doctor may extend this period to two weeks.
Suspension, tablets or powder are prescribed to adult patients according to body weight:
- if body weight exceeds 50 kg, 1500 mg per day is needed
- if body weight is less than 50 kg - 18 to 21 mg per day per 1 kg
Dailythe portion is taken in three divided doses.
Fucidine in the form of a powder is diluted with a buffer solution. In ophthalmology, the solution is applied topically twice a day. After the symptoms of the disease disappeared, the procedure should continue for another two days.
Powder diluted in a buffer solution is introduced into a container with 500 ml of infusion composition. Infusion is performed through large veins for two hours, through superficial veins of small size - at least 6 hours. The remaining solution should not be used categorically if it has been standing for more than a day.
The following infusion solutions are used in combination with Fucidin solution:
- saline solution - 0.5 l
- sodium lactate - 0.5 l
- 4% dextrose solution
- 0.18% sodium chloride solution
- 5% dextrose - 0, 5 l
- 0.3% solution of potassium chloride
- Ringer's solution - 0.5 l
For infants and newborns
- Newborns and children under 18 years of age ointment and cream Fucidin are prescribed as well as adults, up to 4 times a day fortreatment of lesions on the skin.
- Suspension, powder and tablets are prescribed to children at a rate of not more than 21 mg per kg of body weight.
In pregnancy and lactation,
Breastfeeding mothers and pregnant women should not apply ointment or cream to large areas of the skin. Fucidin is prescribed in the period of bearing of the child and lactation only in those cases when it is impossible to select an alternative drug.
Contraindications
Fucidin is not prescribed for:
- infections in newborns with severe physical pathologies
- infections in premature infants
- hypersensitivity to
- bile duct obstruction
- severe liver disease
- rosaceous acne
- syphilis
Rarely prescribed this medication for women intime of gestation and during breastfeeding.
Side effects of
Undesirable effects with Fucidin are extremely rare and can be as follows:
- Skin and subcutaneous tissue: rash, irritation, contact dermatitis, hives, eczema
- On the part of the eye: irritation of the conjunctiva
- For intravenous and oral administration: spasm veins, thrombophlebitis, nausea and vomiting, anaphylaxis, anemia, asthenia, drowsiness
No overdoses of the drug.
Special instructions
- A medicine in the form of an ointment or cream should not be applied to the eyelids, since fusidic acid strongly irritates the conjunctival tissue.
- Auxiliary components in the drug may cause skin allergic reactions.
- Long-term use of the drug is not recommended to avoid the formation of bacterial resistance.
- For the elderly, there is no change in the amount of the drug.
- Application of fucidin does not affect the management of vehicles and work with complex devices.
Interaction with other drugs
The possibility of using Fucidine together with other medicines should be agreed with the treating specialist.
- The efficacy of the drug significantly strengthens the antibiotics of the penicillin and tetracycline series, as well as preparations of similar action Rifampicin and Linkomycin.
- Do not use Fucidine together with antibiotics such as Gentamicin, Vancomycin, Carbenicillin.
- Fucidin solution can not be combined with whole blood, amino acid and lipid solutions, dextrose concentrates.
Reviews
According to patients who have been treated with ointment or Fucidine cream, the drugs work identically. At observance of all medical recommendations efficiency of their high. Cases of overdose, inefficiency and adverse reactions are very few.
Analogues
- Fusiderm
- Fucitalmic
- Fusidine-sodium
- Sodium fusidate