The crucifer is a medication used to reduce body weight, severe atherosclerosis, and other physiological pathologies with high lipid and cholesterol content in tissues. Therefore, today's article will be devoted to indications for use and instructions for the preparation of Krestor, its analogues, substitutes, price and reviews of doctors and patients.
Features of the preparation
Composition
The active substance of the tablets is rosuvastatin calcium. In addition to the active substance, two kinds of substances are included in the formulation of tablets:
- , which promote better absorption of the active substance - stearic magnesium, calcium phosphate, hydrated lactose, crospovidone;
- forming a structure of a tablet form and facilitating the rapid dissolution of digestive enzymes: titanium oxide, glycerol acetate salt at positions 1, 2, 3, iron oxide, hydrated lactose, hypromellose.
Dosage Forms
The only dosage form known in the pharmacy is the tablet form. The difference between the three types of tablets is based on different amounts of active substance, prescribed in the form of engraving on tablets.
Tablets with 10 and 20 mg rosuvastatin contain an engraving on one side of the tablet, where the amount of active substance is noticed at the end of the symbolism "ZD4522 10" or "ZD4522 20".If the symbol "ZD4522" without further digits is located on one side of the tablet, the amount of active substance should be searched on the other side, equal to 40 mg.
The carton can contain 1 or 2 blisters, each containing 7 cruciform tablets. The minimum price of tablets with 10 mg of rosuvastatin is 539 rubles( 1 blister).The highest price for Krestor tablets with the amount of active substance 40 mg( 2 blisters) is registered in 5494 rubles.
Pharmacological action of
The crucifer is active in inhibiting the enzymes of the chain reaction of the formation of numerous cholesterol precursors. The enzyme is active against the secretion of low-density lipids and free cholesterol. The mechanism of lowering the level of low-density lipids is associated with an increase in the number of active receptors for the capture of low-density lipids and their subsequent disintegration.
In addition to the cholesterol formed by low-density lipids and free low-density lipids, the concentration of free triglycerides and associated low-density lipids decreases. Against the background of a decrease in low-density lipids, the level of high-density lipids, as well as cholesterol and triglycerides, associated with them increases.
Pharmacodynamics
The drug used for patients of different ethnic, sexual and age groups showed the same efficacy of its use.
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The opinion of doctors. .. & gt; & gt;
- Patients with a hereditary form of hypercholesterolemia with admission of the Crestor show a decrease in blood lipid concentrations of different densities. The degree of decrease in lipids and cholesterol in this category of patients is directly dependent on the genetic condition of the pathology.
- A greater decrease in low density lipids occurs in patients with a heterozygous condition of the gene alleles of this pathology( 53% of the patients) than in patients with a homozygous state of the mutant allele. However, the lipid profile of the blood decreases in homozygotes to 22%.
Pharmacokinetics
The maximum concentration of rosuvastatin in the blood is detected 5 hours after the use of the Crestor. Every nine out of ten rosuvastatin molecules bind to albumin proteins of the blood plasma. Bioavailability of the drug varies within 20%.
Intermediate and final decomposition of rosuvastatin is carried out by hepatocytes of the liver. Part of the intermediate products of rosuvastatin catabolism( N-desmethyl) has pharmacological activity - 10% of the total pharmacological effect. Other intermediate products of metabolism - lactone metabolites of pharmacological activity do not show.
The half-life of the active substance reaches 19%.The final metabolites are excreted in the majority through the digestive system. About 10% of metabolites are found in urine. The pharmacological action of rosuvastatin has a long-lasting character.
By the seventh day the therapeutic effect begins to show up. After 14 days after taking the Crestor, the maximum effect is achieved. The pronounced effect of the drug is noted for 21 days.
Indications
Indications for the admission of the Crestor is familial hypercholesterolemia by the type of heterozygosity, provided there is no effect after activation of motor reactions and diet. Crestor is also shown in family homozygous hypercholesterolemia in combination with diet and low efficiency of other therapeutic techniques.
The drug should be taken to people with an increase in the level of triglycerides in the blood. Note: The crest is combined with a diet.
Also indications for admission are:
- pronounced arteriosclerosis of vessels as a means of complex treatment with other medications and diet compliance;
- prophylaxis of the onset of coronary heart disease in patients of retirement and pre-retirement age;
- prevention of the occurrence of acute cardiovascular pathologies( stroke, heart attack, etc.);
- high concentration in the blood of reactive C-protein, taking into account the presence of smoking factors, high systolic pressure.
Instructions for the use of the drug Crestor is discussed below.
Instructions for the use of tablets Crestor
The crucifix is consumed regardless of meals. The starting dose should not exceed 10 mg per day. No dose adjustment for persons aged 50-65 years is performed, the remaining patients are observed during taking the tablets for 21 days, after which the doctor makes a decision on the basis of a blood test on a possible dose adjustment.
Patients with too high levels of lipid metabolism, as well as those suffering from familial hypercholesterolemia, may receive an appointment at a higher dosage. The maximum daily dose is 40 mg per day, these patients are subject to special monitoring.
Patients with acute liver disease are limited by the use of the Crestor. In patients with renal pathologies, the dosage of the drug is determined by the severity of the kidney disease. Severe forms of kidney disease exclude the possibility of using even a small dose( 5 mg per day) of the drug.
Contraindications
In addition to the above contraindications, Crestor is not used in cases:
- of an individual intolerance to rosuvastatin;
- combination with cyclosporin;
- weak contraception in women or her absence;
- myopathy;
- risk of rhabdomyolysis.
Side effects of
The frequency of occurrence of adverse events is determined by the dosage of the Crusher. Usually the symptoms of Crestor's side effect disappear when the drug is used on its own. Stability of undesirable phenomena with a high dose of the drug is noted:
- pains and circulations in the head;
- digestive problems( constipation or diarrhea, nausea, pancreatitis, etc.);
- shortness of breath, cough;
- non-insulin diabetes;
- skin problems( itching, urticaria);
- myopathy, myositis, etc.;
- terminal edema;
- polyneuropathy, memory loss.
Special instructions
The treating physician should be aware of taking medication when appointing Crestor, as there is evidence of a sharp increase in rosuvastatin concentration when combined with Ciclosporin, Gemfibrozil, vitamin K antagonists, ezetimibe, erythromycin and other medications.
Reviews
Among the patients' reviews there are many complaints about side effects in the form of dizziness and increased blood sugar. Dosage is better defined individually, there is no data on the passage of adverse events after a long reception of the Crestor.
Some patients are happy with the lowering of cholesterol level, when other drugs were ineffective. There were no adverse events among these groups.
Analogues
Active substance Rosuvastatin can be found both in the drug of the same name, and in Akorta, Tevastor, Mertenil and 3 more analogues. According to the pharmacological group, there are more than 30 analogues with another active ingredient.
Even more useful information about the drug Crestor is contained in the video below: