Aspirin cardio: instructions for use, price, analogies, indications, reviews

Aspirin cardio is a popular medication with acetylsalicylic acid, produced in Germany in tablets surrounded by a shell. It is a good medicine that counteracts the formation of blood clots. Has the properties of aspirin, a long-tested reliable medicine against fever, inflammation and pain.

More details on what is the difference from usual aspirin, about indications and instructions for the use of Aspirin Cardio, its price, its analogs and the responses of doctors and hosters are described in our article.

Features of the drug

Refers to the pharmacological group: Anticoagulants, Antiaggregants. The manufacturer of Aspirin Cardio is the German firm Bayer( Bayer Healthcare Pharmaceutical).

Composition Aspirin cardio

Active ingredient: acetylsalicylic acid( ASA).

Additional components:

• tablet: cellulose powder, corn starch;
• shell: methacrylic acid, ethyl acrylate copolymer, talc, polysorbate, sodium lauryl sulfate, triethyl citrate.

Dosage forms

Produced in the form of round solid tablets of 100 and 300 mg, convex on both sides, in a film-soluble, intestinal, white shell. The protective coating reduces unwanted manifestations of pain, heartburn and ulceration in the stomach. Inside - white homogeneous dense mass.

In a cardboard packing place:

• 2 aluminum-polypropylene plates containing 10 tablets each;
  2, 4 blisters for 14 tablets in each.

Estimated price of tablets Aspirin cardio in the Russian pharmacy network - from 80 to 240 rubles( depends on the number of tablets)

Pharmacodynamics

Pharmacodynamics

Acetylsalicylic acid has the ability to suppress the enzyme cyclooxygenase( COX), eliminating the symptoms of inflammation and pain, and inhibit the synthesis of thromboxane - a substance that causes an increase in pressure, causes platelets to clump into clots and has a strong vasoconstrictor effect.

This ability of Aspirin cardio prevents the formation of blood clots in the deep vessels, which, when detached from the walls, turn into "airborne" emboli, penetrating into the lungs, heart and brain and occluding the lumens of feeding vessels. There is an ischemia( oxygen starvation of blocked areas) and necrosis of cells, which leads to cerebral infarction, myocardium or pulmonary embolism, very often - with a fatal outcome.

• Medical studies show that ASA has other mechanisms of counteracting the aggregation of red blood cells, which is used for various diseases of blood vessels and blood.
• Simultaneously, ASA acts as a means to reduce inflammation, heat and pain, by reducing the sensitivity of nerve endings, leading to the effect of anesthesia.
• Actively suppressing the production of prostaglandins, ASA reduces its influence on the temperature control centers and, therefore, reduces it.

On the pharmacokinetics and what is better aspirin cardio or aspirin, and also what's the difference, we will tell further.

Pharmacokinetics

• After taking the pill - ASA is completely absorbed and absorbed into the blood. With the absorption under the action of enzymes, a partial metabolism of ASA occurs in the liver, with the creation of the main metabolite( an intermediate processing product in the metabolism) - salicylic acid.
• The maximum content of metabolites in the plasma is detected after 25 minutes after the use of Aspirin cardio.
  Because the tablets are closed with a protective film coating, acid-resistant and blocking the dissolution of Aspirin cardio in the stomach, acetylsalicylic acid is released only in the duodenum, where there is an alkaline medium.
• Therefore, the absorption of the active substance is slowed down to about 6 hours, unlike conventional aspirin tablets. If the kidneys are healthy, 85 to 100% is excreted in the urine for about 2 to 3 days.
• Salicylic acid strongly binds to plasma proteins( 65% -97%, depending on the amount of medication taken) and is actively distributed into tissues. Metabolite is able to enter the fetal tissues through the vessels of the placenta and into breast milk. Excretion of ASA from the body is associated with the accepted dose, since its processing with enzymes is limited.
• Half-life when consumed Aspirin cardio in low doses - up to 3 hours and up to 14 hours if the drug is taken in greater amounts( usually when acetylsalicylic acid is taken as an anesthetic).

Indications for use

Because Aspirin Cardio has the property of preventing the formation of blood clots, it is actively used in diseases of the myocardium, vessels with a high probability of thrombus formation, which is provoked by high viscosity of the blood.

Aspirin cardio is advisable in such cases:

• warning of myocardial infarction condition at the existing threatening factors( high cholesterol, diabetes, hyperlipidemia - abnormally high level of fats in the blood, hypertension);
• Prophylaxis of disturbance or stopping the supply of oxygenated blood, brain and heart cells;
• in angina pectoris - in a stable and unstable( stenokardia de novo) form, for which the inconsistency of the pain syndrome is characteristic;
• Stroke prevention( including conditions of brief circulatory disorders in the blood vessels of the brain);
• prevention of thrombosis and subsequent thromboembolism( blockage by thrombi) of the pulmonary arteries and its branches( with the use of oral contraceptives, prolonged immobility of the limbs);
• prevention of pulmonary embolism after extensive surgical interventions and invasive( with penetration through external skin) operations on the vessels, which include:
  • arteriovenous and coronary artery bypass grafting( restoration of blood flow in the cardiac artery bypassing the narrowed portion of the vessel with shunts);
  • balloon coronary angioplasty, the installation of stents extending the heart arteries;
  • endarterectomy and carotid angioplasty.

Pregnancy

Suppression of prostaglandin formation when taking Aspirin cardio can adversely affect fetal development.

• The amount of ASA more than 300 mg per day - which is the usual dose( from 500 mg) taken for anesthesia - in the first trimester causes teratogenic defects in the embryo. Therefore, in this period of bearing the fetus, the medicine can not be used.
• In the second trimester, the doctor prescribes aspirin with extreme caution, analyzing the real need and threat to the mother and child, and in an amount not exceeding 150 mg per day, in short courses( preferably one-time).
• In the third trimester, the amount of aspirin exceeding 300 mg per day causes slowing of the birth process, early intrauterine closure of the arterial duct in the baby, and dangerous blood thinning. The use of the medicine before the birth itself can provoke cerebral hemorrhage, more often in preterm infants. The threat of uncontrolled uterine bleeding in the mother is increasing. Therefore, use Aspirin cardio at the end of pregnancy - is unacceptable.

Lactation

Salicylic acid enters the female milk in small quantities. Single intake of ASA during lactation does not give unwanted reactions in the baby. With prolonged or frequent use of Aspirin cardio, when consuming more than 300 mg per day - immediately stop feeding the baby with breast milk.

The child receives approximately 8% of the amount of medicine taken by the mother. But with frequent and long-term admission, the active substance accumulates in the body of the infant and causes negative effects, including a decrease in blood coagulability, temperature, anorexia.

Instructions for use

Apirin cardio tablets are taken daily at one time, before meals, with warm water in large volumes( up to a glass of liquid). Long-term use of the drug( often - lifelong, but in the absence of negative side effects).

Assignment	Amount, mg, admission mode
Prevention of the following conditions:	daily	every other day
primary myocardial infarction:	100	300
deep vein thrombosis and development of pulmonary thromboembolism	100 - 200	300
repeated infarction	100-300	300
unstable angina	100 -300	300
stroke development and cerebral blood flow disturbance	100-300	300
Thromboembolism threat after vascular surgery	100-300	300
suspected acute infarction	100-300, the first tabletis taken immediately and must be chewed so that the absorption is more active. In the following month, if the infarction could not be prevented, 200-300.	100-300, the first tablet is taken immediately and must be chewed so that absorption is more active. In the following month, if the infarction could not be prevented, 200-300.

Skipping admission

If the tablet intake is missed, in this case immediately drink the missed pill, and then - in normal mode. Do not drink the medicine, if soon it's time to take the next pill to avoid taking a double dose.

Important Features

Aspirin cardio and the required dosages are prescribed by a physician.

• Acetylsalicylic acid can cause bronchospasm, asthma attack, allergic manifestations. Admission Aspirin cardio should be particularly careful with provoking factors such as: bronchial asthma, bronchial obstruction, hay fever, allergy to other medicines.
• The effect of ASA on blood clotting is retained a few days after the end of admission, so there is a high probability of bleeding during surgical operations. If you want to exclude the threat of bleeding during surgery, you should stop using Aspirin Cardio 2 to 3 weeks before surgery.
• Excessive dosages recommended by a doctor are dangerous for internal bleeding.

Contraindications

Drug use requires mandatory consideration and analysis of contraindications to prevent life-threatening conditions. They include:

• allergy to acetylsalicylic acid and its metabolites;
• age group is under 18;
• pregnancy( I and III trimester), feeding the baby with breast milk;
• bronchial asthma triggered by ASA;
• of ulceration, bleeding, erosion of the stomach, esophagus, intestines;
• hemorrhagic diathesis;
• suffered a hemorrhagic stroke;
• concurrent use with medication Methotrexate;
• deficiency of kidney function and clearance of CC less than 30 ml / min;
• is a serious disorder of the liver;
• chronic failure of myocardial function.

Side effects of

Negative manifestations in the use of Aspirin cardio are detected more often in case of an overdose and taking medication without taking contraindications.

Are noted:

• abdominal pain, nausea, acute heartburn, ulceration of the walls of the stomach, 12 duodenal ulcer;
• reversible liver function disorders;
• bleeding during or after surgery due to inhibition of platelet aggregation and blood thinning, hematoma;
• is rare - gastrointestinal, urogenital hemorrhage, cerebral hemorrhage( often - with high blood pressure, simultaneous treatment with medications that increase blood coagulation, such as Warfarin);
• acute, chronic or iron deficiency anemia( due to latent internal bleeding);
• allergic manifestations in the form of spasm of bronchi, rashes, itching, swelling, allergic rhinitis, nasal congestion;
• acute disturbance of respiratory function of the lungs, heart, anaphylaxis.

Special instructions

• Aspirin Cardio is a blood coagulant reducing agent. Together with drugs of a similar action - antiplatelet agents, thrombolytic agents and anticoagulants - the drug is usually not taken, or only after the permission of the doctor.
• Taking Aspirin cardio with gout, a large concentration of uric acid in the blood worsens the condition of patients and can provoke gout attacks in people with a reduced level of excretion of uric acid from the body.
• If a patient suffers from uncontrolled arterial hypertension, the use of aspirin increases the likelihood of hemorrhagic stroke.
• In cases of atherosclerosis of the arteries of the kidneys, serious surgical operations, sepsis, massive bleeding Aspirin cardio increases the likelihood of acute renal failure.

Reviews

• Numerous positive reviews about Aspirin cardio confirm its importance in the treatment of vascular disease and the successful prevention of strokes, heart attack, thrombosis and thromboembolism of the lungs.
• Negative reviews are found in cases where the drug was used without taking into account contraindications and side effects, as well as when the dose was exceeded.

Analogues

Synonyms Aspirin cardio is a medication that matches the action on the body, by composition, active component:

• Trombo ACC - aspirin-coated tablets, coated with enteric coating, manufactured by Lannacher( Austria) - from 138 rubles.
• Uppsarin UPCA( Sanofi, RF, the country of origin France) - effervescent tablets, from 180 rubles.
• Polokard( Polpharma SA, Poland) - enteric tablets from 200 rub.

Analogs are distinguished by a similar mechanism of action with the original, but other active substance or general composition:

• Cardiomagnet( Denmark): ASA + magnesium hydroxide. More suitable for additional nutrition of the heart muscle with magnesium. Tablets do not have a membrane, but magnesium hydroxide protects the lung from the negative effects of ASA.The cost in the range of 153 - 365 rubles.
• Agrenox( Boehringer Ingelheim, Germany): capsules( ASA + dipyridamole), from 955 rub.

Aspirin Cardio is often substituted for drugs, the active ingredient in which is clopidogrel, a more potent substance than ASA.It's Zilt, Plagril, Plavix, Lopirel. They are absolutely contraindicated for self-assignment.