Sulfasalazine is a drug that has antimicrobial and anti-inflammatory properties. In accordance with the chemical structure is the combination of sulfapyridine and 5-aminosalicylic acid. A smaller proportion of sulfasalazine in colitis will be absorbed from the intestinal lumen, after which a uniform distribution in the tissue of the joint will begin. The preparation is affected by the normal level of the intestinal microflora, as a result of which the molecules of the active substances begin to decompose into constituent components. It is these substances that have antibacterial and anti-inflammatory activity.
The anti-inflammatory effect of 5-aminosalicylic acid, due to the fact that it has a low capacity for absorption, will be determined predominantly in the colic walls of colitis. Sulfapyridine has an anti-inflammatory effect, due to the fact that it has better absorption.
Indication for sulfasalazine in colitis
In colitis, the drug is prescribed 4 times a day for 1-2 g, if there is an exacerbation of the disease. Against the background of remission, a gradual dose reduction is carried out, and then a transition to the dosage regimen for the prevention of exacerbation is carried out. Prophylactic dosage is taken for a long time.
For children, a daily dose of 40-60 mg / kg is prescribed in case of exacerbation of colitis. The prophylactic daily infant dosage is 20-30 mg / kg. Use the drug is allowed to children only older than 2 years.
If you take sulfasalazine in colitis, then there will be a decrease in the level of absorption of digoxin and folic acid. Also, anticoagulant drugs and hypoglycemizing sulfonamides are potentiated.
Drug is produced in the form of tablets, which are coated with a film coating of 500 mg. In one package 50 pieces. Tablets have a yellow-brown hue, biconvex, round with a bevelled shape.
Assignment of sulfasalazine in colitis
Before the appointment of the drug, the doctor performs a survey, which includes the delivery of urine and blood tests. The same tests for colitis are carried out regularly when taking tablets. With special care, a medicine is prescribed if there is a presence of hepatic and renal diseases, an allergic reaction and bronchial asthma. If Sulfasalazine has an allergic reaction, then immediate withdrawal of the drug is required.