How is peptic ulcer formed: etiology and pathogenesis

In gastroenterology, peptic ulcer is considered a polyethological pathology. The etiology of the gastric ulcer includes factors that are divided into groups:

  • predisposing;
  • realizing or leading to relapses.

Heredity in the development of pathology occupies an important place and accounts for 50% of cases. It was noted that the prevalence of the disease is several times higher in patients whose relatives suffer from an ulcer. Specificity of blood groups also affects the occurrence of pathology. It also takes into account the inheritance of the nervous function, anthropological features( asthenic physique) and personality characteristics.

Among those patients who have gastric ulcer, the etiology of the disease depends on neuropsychiatric loads( stresses), dysfunction of the vegetative system, which relate more to the realizing factors. Among all the factors, the alimentary cause or eating disorders and bad habits are distinguished( smoking, alcohol).It is proved that rough, spicy and spicy food leads to irritation of the mucosa, and nicotine leads to narrowing of the vessels and increased secretion of the stomach.

Etiology and pathogenesis of peptic ulcer often depends on the intake of alcohol. It increases the aggressiveness of gastric juice, reduces the barrier activity of the mucosa. Medications are also often cause irritation of the mucosa. In particular, ulceration can cause non-steroidal anti-inflammatory and hormonal drugs. This happens because the qualitative composition of mucus changes, its secretion decreases. As a result, the protective function of the mucosa decreases.

The pathogenesis of peptic ulcer disease directly depends on the bacteria discovered in 1984.The name of this bacterium is Nonlicobacter pylori. It is proved that the bacterium lives on the mucosa and affects it. Together with the above facts, there are data that pathology occurs against the background of diseases of other organs. Chronic processes in the cardiovascular system, lungs, pancreas, liver lead to a decrease in the normal function of digestion.

Scientists have established how a stomach ulcer is formed. For its occurrence, there is not enough isolated pathogenic factor. There should be several interrelated factors. In youth, attention is focused on heredity, the average age is prone to pathology due to neuropsychic stresses, inaccuracies in nutrition, bad habits. In old age, concomitant diseases and the use of drugs prevail.

  • Share