Liprimar is a fast-acting agent that helps lower cholesterol in the blood. This effect allows you to achieve the normalization of the heart muscle, which reduces the likelihood of serious and even fatal diseases.
Despite the relatively high cost, the drug has proved to be one of the most reliable in its segment, so many prefer it to him. Therefore, today we will talk in more detail about the indications for use and instructions of Liprimar, its price, analogues and reviews of doctors and patients about it.
Features of the drug
The drug does not impair the speed of the psychomotor reaction or concentration, so it can be taken when working with complex mechanisms. It also does not affect the ability to drive.
When an overdose occurs, there is a risk of symptomatic side effects. Antidote for eliminating the effects of overdose does not exist, so treatment is reduced to standard methods, including gastric lavage. Hemodialysis is ineffective, symptomatic therapy.
Composition
1 tablet contains a different amount of active substance atorvastatin, which is present in the form of calcium salt. As auxiliary components, the agent can contain:
- polysorbate 80,
- simethicone emulsion,
- microcrystalline cellulose,
- magnesium stearate,
- calcium carbonate,
- carboxymethylcellulose sodium,
- lactose monohydrate,
- candelilla wax( other than tablets 80 mg).
Dosage forms
The product is available in the form of elliptical tablets, which are film-coated. The active substance in them can be contained in an amount of 10 mg, 20 mg, 40 and 80 mg of atorvastatin.
Liprimar has a fairly high average price, which varies and depends on the size of the active substance, as well as on the number of tablets in the blister. The lower price bar is located in the area of 700 rubles. For volumetric packing( 100 pcs.) To give it is necessary about 2500-2800 thousand rubles.
Pharmacological action
- The main action of Liprimar is hypocholesterolemic, hypolipidemic. It is aimed at reducing harmful lipids, reducing their absorbability and replacing them with dense and useful categories of fats. The drug is excellent for family forms of hypercholesterolemia, in which conventional drugs from the hypolipidemic category do not give results.
- With angina pectoris( when Q tooth is missing), atorvastatin significantly helped reduce the risk of hospitalization, mortality and subsequent complications.
When taken orally, the medicine is well absorbed. The number of fatal outcomes with the development of a heart attack, stroke or other heart diseases becomes less. Liprimar practically does not affect puberty, but its use is not recommended in adolescence, although it is possible.
For prevention and treatment of cardiovascular diseases, our readers advise the drug "NORMALIFE".This is a natural remedy that affects the cause of the disease, completely preventing the risk of getting a heart attack or stroke. NORMALIFE has no contraindications and begins to act within a few hours after its use. The effectiveness and safety of the drug has been repeatedly proven by clinical studies and long-term therapeutic experience.
The opinion of doctors. .. & gt; & gt;
Pharmacodynamics
- Atorvastatin is the main component of the drug, it lowers the level of lipoproteins and cholesterol. The total level of lipoproteins is reduced by 40-60%, cholesterol by 30-48%, TG and apolipoprotein-B by 33% and 50%.
- The same drug promotes the increase in high-density lipoproteins, which has a beneficial effect on the condition.
- At a dosage of 80 mg, Liprimar is guaranteed to reduce the risk of angina pectoris, ischemia, myocardial infarction.
- The mortality rate is also reduced by 16%, and the likelihood of re-hospitalization is 26%.With different baseline indicators, the efficacy remains high, the age, sex or disease category has little effect on the end result.
The dose is always selected taking into account the therapeutic effect, because for different stages and degrees of disease, you need your size of the remedy. Prevention of atorvastatin is indicated in the presence of a risk of heart complications arising from such pathologies as:
- diabetes mellitus,
- different types of stroke,
- atherosclerosis,
- arterial hypertension,
- heart failure.
Liprimar is used for primary and secondary prevention.
Pharmacokinetics
The basic substance is absorbed very quickly and after only 1-2 hours in the blood, maximum amounts of the drug can be observed. Increase in the rate of absorption and maximum concentration will be higher when taking large doses. Systemic bioavailability of about 30%, absolute - 14%.
Low score is justified by passing through the gastrointestinal tract and liver. Also absorption is capable of food, however, there has been no decrease in the effectiveness of the drug. Digestibility does not depend on the time of taking the remedy, in spite of the fact that in the morning it is more quickly detected in the blood plasma( compared to the evening indices by 30%).
Atorvastatin penetrates poorly into erythrocytes, but has an excellent connection with blood proteins( up to 98%).It is excreted from the body Liprimar after extrahepatic or hepatic metabolism with bile. The blood content drops after 14 hours, but due to the activity of metabolites, the inhibitory effect persists for up to 30 hours.
Indications for use
Indications for the use of the drug are:
- With a large number of low-density lipoproteins in the blood, as well as total cholesterol, apolipoprotein B, triglycerides. Particularly shown in those cases when after non-drug exposure( exercise, diet), the normalization of the cholesterol level is not achieved.
- Patients with disbetalipoproteinemia, with elevated serum triglyceride levels, when diet therapy does not result.
- Family homozygous form of hypercholesterolemia.
- With an unfavorable prognosis of ischemic heart disease or other cardiac pathologies. In particular, for the prevention of a high risk of angina pectoris, myocardial infarction, stroke.
- To reduce the need for revascularization or dyslipidemia in patients with cardiac problems.
It is also necessary to take Liprimar in cases when the disease has not yet been detected, but there are the main signs of the likelihood of developing CHD: smoking, having an anamnesis of relatives of early cardiac pathologies, age over 55, small concentrations of Xc-HDL, hypertension.
Pregnancy should not be taken with a medicine. Women who are in the reproductive period should use adequate methods of contraception at the time of taking the remedy. When planning pregnancy or the likelihood of conception, the drug should be replaced with another medication, since Liprimar negatively affects the fetus. Since the exact impact on the child's body is not studied, its use at this age is prohibited.
How to take Lipimar, the next section of the article will tell.
Instructions for the use of tablets Liprimar
Take the drug inside, regardless of the period of the day or meals. Before using the drug, diet therapy should be used, try to lower cholesterol by reducing weight and regular exercise, paying special attention to the treatment of the underlying disease. To maintain a special diet is necessary and in the period of admission Liprimar.
Dosage is selected individually, but you can not use more than 80 mg of medication per day. The level of lipids after the administration of tablets is controlled for several weeks.
- In primary or mixed hyperlipidemia, a one-time intake of 10 mg is sufficient. The maximum therapeutic effect is manifested after 2-3 weeks of continuous therapy.
- Deficiency of renal function. Dosage is selected individually, but impaired renal function does not affect the absorption of the drug.
- In case of insufficient liver function, the dose of Lipimar must be reduced without fail.
- Family homozygous hypercholesterolemia. Use 80 mg of the product at a time.
Special adjustment of the selected dose is necessary when combined with other drugs.
Contraindications
- pregnancy,
- age under 18,
- lactation,
- unclear genesis and serum elevated transaminase activity,
- sensitivity to the main components of the agent,
- active liver pathology.
With special care, Liprimar is indicated for use in patients with previous liver disease, as well as in problems with alcohol. A special prohibition is imposed on the lactation period, since it is still unknown with accuracy whether atorvastatin is excreted in breast milk. Stop taking immediately after pregnancy, to avoid undesirable consequences for the child.
Side effects of
Undesirable effects develop in very rare cases, but it is impossible to completely eliminate this possibility. Side effects from various areas of the body are as follows:
- GI: diarrhea, pain, constipation, nausea, flatulence, indigestion( impaired digestion), pancreatitis, glucose concentration change.
- CNS: asthenic syndrome, headaches, insomnia, paresthesia, weakness.
- Hepatobiliary system: hepatitis, increased activity of hepatic transaminases, jaundice.
- Bone and muscle tissue: myopathy, myalgia, myositis, muscle cramps.
- Allergic reaction: rash, itching, urticaria.
Other side effects are even less likely to develop( less than 1%).These include:
- baldness,
- anorexia,
- erectile dysfunction,
- weight gain,
- chest or back pain,
- malaise,
- amnesia,
- arthralgia,
- vomiting,
- bullous rash,
- Lyell's syndrome,
- thrombocytopenia,
- peripheral edema,
- Stephen-Johnson syndrome,
- hypoglycemia or hyperglycemia.
Special instructions
Liprimar is a lipid-lowering drug, and it is typical for them that after application, an increase in serum activity of hepatic transaminases is possible. And a strong and persistent increase occurs only with a probability of 0.7%.The higher the dose, the more likely the appearance of persistent activity.
No special symptoms, including those characteristic for high activity of hepatic transaminases, are not observed. Both after cancellation and after lowering the dosage their activity comes back to normal, and low doses of the drug do not cause a repeated development of pathology or other consequences.
Indicators of liver function are necessarily monitored before Liprimar is taken, and again at 6 and 12 weeks. If the activity of liver transaminases has increased or signs of liver damage have appeared, then the control should be constant until the indicators come back to normal.
Myopathy( muscle pains) was observed in people prone to developing myalgia. With a serious increase in CKK or signs of myopathy, Lipimar should be discontinued immediately. Appearing myopathy is most likely when the drug is combined with drugs of the following categories:
- fibrates,
- antifungal agents,
- immunosuppressants,
- nicotinic acid,
- erythromycin.
With the expected high benefit from Liprimard with simultaneous application of the means described above, the patient should additionally be observed by the doctor.
Atorvastatin - the main component of the drug, is capable of provoking the activity of CK.At a risk of renal failure, myopathy or the likelihood of rhabdomyolysis( extreme degree of myopathy), the medication is limited. For the future, patients are warned about the likelihood of such manifestations, so for any manifestations of fever or weakness in the muscles, he should immediately visit a doctor.
Reviews
Patients taking Liprimar respond positively to the drug. Especially there is a powerful effect, which allows in a limited time to significantly affect the amount of cholesterol in the blood, lowering it. Some argue that ischemic manifestations and symptoms also gradually go away on a background of constant medication.
Do not ignore the fact that the tablets have a limited list of contraindications and side effects, which develop in the most rare cases. The category of shortcomings include the need for a long reception to maintain the proper effect, as well as a high price.
Analogues
Analogues of
To the list of analogs include medicines:
- Atomax,
- Ator,
- Torvacard,
- Atorvastatin,
- Anvistat,
- Atoris,
- Lipford,
- Novostat,
- Vasator,
- Torquard,
- Lipon,
- Torvas,
- Torvalip.
About analogues of Lipimar, as well as its interaction with other drugs and similar nuances will tell this video: