Drug Dermozolone is used in dermatological practice as an anti-inflammatory drug. The drug has an effect against fungi and bacteria in the skin. It is used as an external agent, is produced on an ointment basis.
Therefore, today we are poem for ointment Dermozolone, instructions for its use, the price in pharmacies, reviews and analogues of the drug.
Features of the preparation
Composition
Dermozolone contains adjuvants to achieve the consistency and viscosity of the preparation: wax, petrolatum, cetyl alcohol and liquid paraffins. As the main substances that have a medicinal effect on the affected skin, we use clioquinol and a synthetic hormone - prednisolone.
Ointment Dermozolone has water solubility due to cetyl alcohol and substances that promote hydrophilicity of the agent and are solvents for paraffins and waxes: polysorbate 60 and methyl parahydroxybenzoate.
Pro form and prices for shampoos and cream dermozolon we'll fade below.
Dosage Forms
Dermozolone is available in a single dosage form suitable for external use - ointments. Ointment is released in tubes with a mass of 5 grams. Interruptions in the production of the drug make it difficult to determine its value.
Pharmacological action
The drug eliminates the symptoms of itching, allergic reactions, disinfects and removes the inflammatory reaction in the area of application to the skin.
Farmakodinamika Dermozolona
Prednisolone reduces the lumen of the blood vessels of the skin, reduces the penetration of substances through their walls. The action of the substance is aimed at reducing the rate of maturation of fibroblasts and the penetration of monocytes into the affected foci of the skin, resulting in the localization of the inflammatory focus only at the site of injury. Prednisolone normalizes the structural function of the cell membrane lysosomes. With the action of the drug, the alternative and exudative functions of the inflammatory process are inhibited.
Clioquinol acts destructively on the enzymatic properties of prokaryotes and microscopic fungi on the skin surface. Clioquinol has the ability to inactivate Gram-positive pathogenic skin bacteria, yeasts and fungi that cause dermatomycosis( Microsporum, Trichorhyton and Epidermorhyton).
Pharmacokinetics
With external use of Dermozolone, the active substance prednisolone is absorbed partially into the bloodstream. In the free state does not occur, detection in the blood is possible in conjunction with blood proteins albumin and transcortin. Prednisolone is excreted through the digestive and urinary systems.
Approximately half of the substance is removed unchanged, the remainder - in the form of intermediate products of decomposition. The conversion of prednisolone into intermediate metabolites occurs in the liver during oxidation-reduction reactions. The non-oxidized portion of prednisolone binds to sulfate ions and glucose derivatives.
Clioquinol when exposed to the skin enters its blood vessels in small amounts. In a free form in the blood does not occur, only in the peptide-clioquinol complex. Intermediate decay occurs in the liver. Clioquinol is excreted by the urinary system.
Instructions for use
Dermozolone is used externally. Applying the drug to the affected area of inflammation is recommended to do with light rubbing up to 3 times a day.
No confirmed data on the harm of the drug on the body of a pregnant or lactating woman, but, if possible, it is recommended to replace the drug with softer analogs. The same pattern should be observed in the treatment of infants, infants and children of nurseries.
Indications
Dermozolone is used as an external agent in the treatment of skin diseases:
- fungal disease between the toes,
- most types of dermatitis,
- skin infections,
- eczema caused by bacterial pathogens.
Effective in primary and secondary skin infections. It is often prescribed with itching around the anus and in the area of the external genitalia.
Contraindications
The dermatologist does not prescribe an ointment for treatment if the patient exhibits an individual intolerance to individual components of the drug. In addition, categorical contraindications are:
- skin diseases of a viral nature;
- chicken pox;
- violations of the integrity of the skin( wounds);
- cutaneous tuberculosis;
- malignant, benign and other types of neoplasms, skin conditions preceding cancer;
- syphilis;
- is a perioral dermatitis;
- skin reactions to vaccination of the body.
Side effects of
Following the instructions for use and the treatment plan suggested by the dermatologist, Dermozolone is tolerated by most patients satisfactorily. Dermosolone application on a large area of the skin can cause minor side effects that cause discomfort to the patients:
- skin irritation as a response to the iodine component of the drug;
- dryness and slight burning of the skin;
- purple;
- hyperlipidemia with possible inflammation of the sebaceous glands;
- excessive sweating.
With prolonged use of the ointment, problems may arise outside the dermatological area. The nature of the problems is determined by the long-term hormonal effects and concerns the violation of the production of glucocorticoids by the adrenal cortex, mental abnormalities, decreased immunity, menstrual cycle failure, etc.
Special instructions
- The use of Dermozolone requires prior consultation with a dermatologist.
- When applying the drug, it should be noted that the contact of the ointment with the fabric of clothing can leave traces in the form of a change in its color.
- Prolonged use of the ointment is fraught with not only strong side effects, but also the resistance of pathogenic bacteria to the constant effects of clioquinol.
- The term of the drug is 4 years. Store Dermozolone in a dark place at a temperature below room temperature.
There are no side effects from the interaction of Dermosolon with other medications.
Reviews
Patients who used Dermazolone note the speed and effectiveness of the drug.
The only negative about which many users write is a small production of ointment and its frequent absence in pharmaceutical points. The use of analogues of Dermozolone, according to patients, is less effective.
Analogues
The closest analogues of the ointment for the chemical composition are Lorinden and Candide, the cost of which ranges from 320 to 760 rubles per 15 g tube.