Amoxicillin is a broad-spectrum antibiotic used to treat various bacterial infections. Today it is produced by many companies, therefore it is presented in a wide range of prices and forms.
Composition, form of release, packing
Available in different forms: tablets, capsules with powder inside. There are also granules used to prepare the suspension. The main active substance is amoxicillin in the form of trihydrate. Excipients: polyvidone, magnesium stearate, talc, sodium carboxymethyl starch, titanium dioxide and hypromellose.
A semisynthetic drug from the penicillin group has a cardboard package. Tablets are oval or oblong with notches on both sides. Capsules are 250 and 500 mg each. In one package 16 pieces. The granules are immediately in the vial. The introduction of antibiotics by injection is not provided.
On the photo of the form of the release of Amoxicillin
Manufacturer
The drug is produced by several companies:
- Biochemist,
- Hemofarm( Serbia),
- Natur Produkt Europe B.V.(Netherlands),
- ABVA-RUS,
- Barnaul Medical Products Plant,
- Dalhimfarm,
- Organic,
- STI-MED-SORB( Russia).
Indications
Used for the treatment of infectious inflammatory processes caused by microorganisms sensitive to the main active substance. It is mainly prescribed for:
- bronchitis,
- angina,
- pyelonephritis,
- pneumonia,
- cystitis,
- bacterial infections of the digestive system,
- gynecological problems.
Contraindications
It is necessary to refuse treatment with Amoxicillin for:
- Hypersensitivity to the components of the drug.
- In case of allergic reactions to penicillin and other beta-lactam antibiotics.
- Severe digestive disorders.
- Acute lymphoblastic leukemia.
- Aged to three years.
You can not drink tablets and those who suffer from infectious mononucleosis, bronchial asthma. Will not bring the desired result and with viral infections, acute respiratory infections, colds.
Mechanism of action
Amoxicillin is an antibacterial, acid-fast, broad-spectrum agent. Due to this, it affects both gram-positive and gram-negative microorganisms. It is also active against microorganisms that have shown sensitivity to penicillin G. These include streptococci, staphylococci, which do not produce penicillinase.
The medicine is not destroyed under the influence of gastric juice, completely absorbed from the digestive tract. The maximum amount in the plasma is reached after about 1-2 hours. The binding of the active component to plasma proteins is 20%.The drug is distributed to all tissues and body fluids.
Instructions for Use
Tablets are given in a dosage of 500 mg three times a day. This scheme of admission is suitable for adults and adolescents over 12 years. In severe bacterial infections, dosage may be increased, but not more than 6 g.per day.
High doses should be taken with typhoid fever, leptospirosis. The course of treatment continues after the disappearance of symptoms for another 2-3 days. Usually it is from 5 to 12 days.
Suspension is used by children. It is prepared immediately before the beginning of treatment. To do this, add cold water to the bottle. Then the mixture is shaken. Store the finished suspension can be no more than two weeks.
Children under 2 years can take no more than 20 mg / kg. Up to five years, a dose of 125 mg is prescribed. Children up to 10 years of single dose increases to 250 mg.
Instructions for Use Amoxicillin:
Side effects of
Side effects are expressed in different reactions. With prolonged admission, dizziness, confusion, depression may develop. Sometimes it is noted:
- Allergies( urticaria, Quincke's edema, rhinitis, conjunctivitis).
- Superinfection. It is characteristic for patients with chronic diseases.
- Negative reaction of the digestive system. It is expressed by nausea, vomiting, dysbiosis, taste change.
Side effects from the central nervous system are extremely rare.
Overdose
The probability of overdose is very small. Among the symptoms of severe diarrhea. For treatment, the medication is stopped and symptomatic treatment is prescribed. Amoxicillin can be removed from the bloodstream by hemodialysis.
Specific instructions
Suspension contains sucrose, so gently it should be taken to people suffering from diabetes mellitus. After use, you should drive the car with care or manage potentially dangerous mechanisms.
Persons under 18 years of age, as well as patients with renal and hepatic problems, are not recommended to combine the drug with Metronidazole. During pregnancy, the drug is prescribed only if the benefit exceeds the possibility of harm to the child.
No cases of negative influence of amoxicillin on the course of pregnancy and childbirth have been revealed. The active ingredient penetrates into breast milk, can cause allergic reactions in the newborn and the violation of its microflora.
Children are allowed to give an antibiotic from 4 weeks in suspension. It is necessary not only to comply with the dosage, but also to maintain the gap between the medications. It must be at least 8 hours.
Drug Interaction
The drug reduces the effectiveness of oral contraceptives. If it is taken simultaneously with other antibiotics, a synergistic( intensifying) effect is noted. In combination with bacteriostatic drugs, antagonism is noted.
The drug stimulates the effect of anticoagulants, reduces the prothrombin index. When interacting, the effect of medications is reduced, in the process of metabolism which manifests itself PABC.
When combined with clavulanic acid, there is no change in pharmacokinetics. The microorganisms producing penicillinase are resistant to the main active substance.
Rules for taking antibiotics in our video:
Reviews for
Often Amoxicillin is prescribed for sore throats. This allows not only to reduce the total time of the disease, but also to avoid the occurrence of consequences. Reviews about the drug are mostly good.
Price for Amoxicillin
The cost of tablets is low. Tablets of 250 mg will cost 35-50 rubles( 20 pcs.).Capsules are slightly more expensive - about 100 rubles. Granules have about the same cost as the capsules. The price depends on the manufacturer. The cheapest tablets produced by JSC Avva Rus.
Analogues of
There are several drugs that contain a similar main component:
- Amoxicillin trihydrate,
- Amoxicillin Sandoz,
- Flemoxin Solutab,
- Amoxicillin Sulbactam,
- Amoxisar.
Cheap
The cheapest is Amoxicillin itself. Inexpensive cost have:
- Ecobol,
- Amosin,
- Ospamox.
Synonyms of medication
Amine, Amoxylate, Apo-Amoxi, Gonoform, Grunamox, Dedoxyl, Izoltil.
Analogues of Amoxicillin
Conditions for dispensing from pharmacies
It is only available by prescription.
Storage conditions and shelf life
Store in a dark place at a temperature below 25 degrees. Shelf life is up to three years from the date of manufacture.