Being one of the most effective antifungal drugs of the latest generation, Itraconazole has a wide range of uses, with the minimum amount of adverse events, and is allowed to use even in childhood. This is due to the balance and thoughtfulness of the composition of the product, its ease of use and the choice of dosage form. At the same time, all the varieties of itraconazole offered today have a pronounced effect on the neutralization of all kinds of fungal infections.
With the help of the given preparation it is possible to treat the skin even in remote places, even sensitive parts of the skin and deep folds do not show allergic manifestations when using the drug Itraconazole. The localization of the pathological process does not matter: everywhere the drug destroys the fungal infection, cleaning the skin and eliminating the traces of inflammatory processes that can accompany these lesions. Today we will consider the instructions for use and the price of Itraconazole, reviews about it and analogues of the drug.
Features of the preparation
The use of Itraconazole is not difficult: the ointment and cream are well absorbed by the skin, the capsules and tablets are quickly absorbed in the gastrointestinal tract, and the decay products are excreted by the kidneys within a month after starting the drug. The treatment regimen should be appointed by the attending physician-dermatologist, who before that should conduct a full examination of the affected skin areas, take into account the general health of the patient.
Neutralizing and suspending the process of production by the body of ergosterol, which is necessary for the normal development and functioning of pathogenic microflora, the active substance of the preparation quickly eliminates the possibilities for the action of fungal infections. At the same time, even when the drug comes into contact with areas with healthy skin, there is no adverse effect.
Composition of Itraconazole
The balance of the composition determines both the high degree of effectiveness of Itraconazole and its speed, which is important in the advanced stages of fungal lesions. The active substance of the drug is Itraconazole, which is contained in equal proportions in various dosage forms of the drug.
The following ingredients should be referred to excipients:
- hypromellose( hydroxypropylmethylcellulose E-5);
- methyl methacrylate copolymer;
- dimethylaminoethyl methacrylate;
- butyl methacrylate;Saccharose
- or sugar.
These substances are included directly in the capsules or ointments;the capsule shell itself consists of a gelatin base, a titanium dioxide.
Dosage forms
In the sale of the drug is offered in several varieties that have the same pronounced therapeutic effect and allow in a short time to get rid of the manifestation and cause of the fungal infection. Tablets, capsules, suppositories, ointment and cream are medicinal forms of the release of the drug Itraconazole provide a complex effect on the body with different localization of the pathological process.
- Capsules and tablets are offered in polymer blisters for 5-15 pieces each, with the blister packaged in a cardboard box on the surface of which there is information on the name of the drug, the manufacturer and the expiration date of the product.
- Ointment and cream are offered in aluminum tubes weighing 15 grams, which are also located in a cardboard package.
The cost of the drug may vary slightly among different vendors, and its price can range from 355 to 890 rubles per package.
Pharmacological action of
Neutralization of the microflora of a fungal infection is due to the composition of the drug, the balance of its components. Rapid action in the form of elimination of edema of tissues, a decrease in the sensitivity of affected areas of the skin, removal of inflammation that accompanies fungal lesions - the main manifestations of the antifungal drug in question. The agent Itraconazole differs from the analogues with a high degree of efficiency, which is due to the good reactivity of the active substance and the balanced composition.
Pharmacodynamics
The penetration of the active substance into both the skin layers and the mucous membranes occurs immediately after administration or application of the agent - this explains the high degree of effectiveness almost immediately after the beginning of the use of this agent.
Pharmacokinetics
After completion of the application, the constituent components are excreted for a short time by the kidneys. Because of its high effectiveness, Itraconazole should be applied in a course, the duration of which is determined by a dermatologist, and which should be at least two weeks.
Indications
To indications for the use of the drug Itraconazole should include any type of violation of the integrity of the skin due to its mechanical damage with the development of fungal infection on it and the presence of inflammatory processes of varying intensity. Also due to its composition, the drug can be used to relieve swelling of the skin, reduce itching and burning.
Indications for the use of Itraconazole include the following pathological conditions:
- dermatoses;
- candidiasis;
- flat lichen;
- keratomycosis;
- pityrious and multicolored lichen;
- mycotic eczema( large lesion area);
- dermatophytosis;
- sporotrichosis;
- mycoses of various varieties( including chromomycosis, onychomycosis).
Indications for the use of the drug in various dosage forms are fungal infections that affect the skin and mucous membranes, as well as nail plates.
Instructions for use
The use of the drug is carried out by applying it on the affected surface, without the need for rubbing it and applying a fixing bandage. This applies to cream and ointment. The frequency of application can be different: 1-3 times a day, depending on the state of the affected surface. The method of use is determined by a dermatologist in accordance with the number of symptoms and the skin condition of the patient. The instructions accompanying the drug allow us to understand the scheme of application for each specific skin lesion.
Capsules and tablets are taken orally by drinking plenty of drinking water. The dose should also be determined by the doctor to prevent the occurrence of side effects. Usually 1 tablet or capsule is prescribed 3 times a day. The duration of taking tablets and capsules is from 1-2 to 4 months without breaks, then, after a break, a second course of treatment can be prescribed.
The following describes the side effects of Itraconazole.
Side effects of
The side effect is the probability of appearance of pigmentation in the treated area of the skin in case of using ointment or cream, increasing its sensitivity to mechanical influences, as well as the appearance of acne of varying intensity. There may be increased dryness of the skin, its peeling.
Contraindications
To situations where the use of this drug may not be indicated, include increased sensitivity of the skin, individual intolerance of the components of the drug, kidney or liver failure.
Special instructions
- Pregnancy requires extreme accuracy when using Itraconazole: its increased activity when applied to the skin can cause irritation of the skin, but its components do not penetrate into the placenta and can not adversely affect the developing child.
- Lactation and child age are also situations that require monitoring of the use of Itraconazole under the supervision of a physician.
Interaction with other medications
A comprehensive approach to treatment allows you to get the fastest and most pronounced results, which is especially important when the body fungus infection and the neglect of the pathological process. The absence of negative manifestations when using Itraconazole with drugs with a similar effect makes it possible to assign it a parallel course.
- The suppressing isozyme CYP3A4 Itraconazole enhances the effect of Iressa.
- Itraconazole is able to cause an increase in the concentration of the drug Spreisel in the blood, so they can not be combined.
- Simultaneous administration of Vincristine with Itraconazole results in neuromuscular disorders.
Reviews about the drug Itraconazole from the fungus of nails, with thrush and other ailments are given below.
Reviews
- According to reviews of those who have already used the drug Itraconazole in the fight against fungal infection, this tool is not only easy to use, but also has a quick effect even with a neglected pathological process: the symptoms of the underlying disease are significantly reduced,as a swelling of the skin, its inflammation and peeling.
- Nails with a complex use of Itraconazole quickly restore its structure and appearance, become stronger, eliminates their stratification and crumbling. And the availability of value can be called an additional advantage of using the drug.
- According to specialists in dermatology, Intarconazole is well suited for those who have increased sensitivity of the skin, since it rarely shows cases of allergic manifestations.
Do itraconazole analogs are cheaper, we will tell below.
Analogues
Similar preparations for the control of various types of fungal infection are the preparations Flucinar, Sinaflat, Flucort, which showed good results in both complex therapy and monotherapy.
A lot of controversy concerns the question of what is best, Itraconazole or Irunin, or Fluconazole. But there is no consensus.