The main feature is the ability to form strong specific bonds with DNA.The anticancer activity of the drug was discovered in 1962.
Composition, form and storage conditions
Is available as a concentrate for the preparation of an infusion solution. Produced in bottles of 10, 25 or 50 ml. Cisplatin-Teva is available as a solution for injections.
The period of use depends on the type of release. For a solution, it is 2-3 years. For lyophilizate - 3 years. After the end of this period, the medicine is not used. The product is stored at a temperature of up to 25 degrees.
Manufacturers
Produced by different manufacturers:
| Country | Manufacturer | Form |
|---|---|---|
| Netherlands | Teva / Pharmachemie B.V | Solution for injection 0.5 mg / ml 20ml. |
| Germany | Fresenius Kabi Deutschland GmbH | Concentrate for the preparation of infusions. |
| Israel | TEVA Pharmaceutical Industries Ltd. | Lyophilizate for formulation for injection 10 mg: 1 or 49 bottles. |
| Russia | Lance Pharm | Concentrate for the preparation of a solution for infusions 0.05% |
Indications for use
The drug is commonly used in combination chemotherapy to treat cancer.
Activity is at very high marks in the fight against oncology:
- testis,
- cervical and fallopian tubes,
- ovary,
- lung.
High efficacy is proven in the treatment of cancer of the urinary system, prostate, stomach and esophagus. Moderate activity was found in soft tissue sarcoma, thyroid and breast cancer, in the treatment of melanoma.
Contraindications
Intolerance of compounds, of which platinum is a part.
Can not be taken in any form in case of impaired renal function, oppression of bone marrow hematopoiesis, heart failure or during pregnancy and lactation. The condition may worsen with a decrease in hearing.
Pharmacological action
Active components instantly enter the bloodstream after administration. They are characterized by a rapid distribution in body fluids, various tissues.
High concentrations are determined in the prostate gland. Lower - the bladder, muscles, testicles, spleen. As the agent passes through the BBB, the concentration of the main component in the interracial tumors is lower.
Transformation of cisplatin occurs in the liver due to nonenzymatic transformation. The result is also the formation of inactive metabolites. The remedy is allocated mainly with urine: 15-25% is excreted unchanged.
With the administration of the drug every day there is a danger of the accumulation of free platinum in the blood plasma.
The substance can be withdrawn from the systemic blood stream only by dialysis, using it within the first three hours after the administration of the drug.
Instructions for use Cisplatinum
The agent is used as a monotherapy or in combination with other chemotherapy methods.
To reduce the likelihood of toxic effects on the kidneys, hydration is performed using up to two liters of fluid. If the procedure is not sufficient for a complete diuresis, then a diuretic is administered.
When administered intravenously, the droplet speed should not be more than 1 mg per minute. Prolonged infusions can take place for 6-24 hours. Do not use glucose solutions to dilute Cisplatin.
Aluminum reacts with the active component of the drug. Therefore, it deactivates and precipitates. For this reason, it is important not to use needles, equipment with aluminum during the preparation and during the introduction.
Side effects of
- Possible damage to the kidneys of , accompanied by a disturbance in the work of the renal tubules. This is detected more often in the second week after dosing. Renal insufficiency is moderate or insignificant. The process is reversible.
- From the digestive side of , patients can note the development of nausea, vomiting. They appear within 60 minutes after the administration of the remedy.the symptoms disappear after 24 hours. The severity of the symptoms is reduced by dividing the total dose. There may be abdominal pain and constipation.
- Sometimes, the hematopoiesis of is marked by myelosuppression. With the introduction of standard doses, it is reversible. The lowest level of platelets and leukocytes is observed for the second week and is restored after 4 weeks.
- On the part of the hearing organs , there is a one-sided or two-sided noise in the ears. The defeat of this system depends on the dose. Usually, hearing loss is observed in young and elderly patients.
Overdose of
Among the symptoms that indicate the introduction of large doses, says: vomiting, neuritis, bone marrow depression, dizziness, bleeding.
Treatment is carried out in a hospital.
It is mandatory to monitor vital organs. First, the symptoms are removed. If necessary, blood transfusion is prescribed, the appointment of antibiotics or antiemetics.
Special instructions
When administered, it is essential to monitor the functioning of the kidneys, the number of erythrocytes, white blood cells and neurological status.
The risk of development of anaphylactic reactions, in persons with allergic reactions in the anamnesis, is also taken into account. In juveniles, the probability of developing otoxicity is higher than in adults.
To maintain the sterility of the drug, dilution of the drug is carried out before administration.
Infusion should be completed within a day after the preparation of the solution. In case of accidental contact with the skin and mucous membranes, the affected area is immediately washed with a large amount of liquid.
Pregnant medical personnel should not interact with this medication.
Interaction
The risk of nephropathy increases, if taken jointly by uricosuric anti-arthritis agents.
Antihistamines mask the ototoxic effect. The simultaneous use of cisplatin with antibiotics-aminoglycosides leads to nephrotoxic or ototoxic action.
It is proven that the drug disrupts the excretion through the kidneys of Methotrexate and Blemycin. Therefore, increases their toxicity.
Reviews
Cisplatin is one of the effective ways to cope with cancer. The doctors' comments indicate that the effectiveness of the remedy is very high.
While patients complain of poor health. Immediately after the procedure, repeated vomiting is noted, but it can be defeated using various anti-emetic drugs. Seizures and other serious side effects are usually observed with an improperly selected dose of the drug.
Price of Cisplatinum in Moscow
The most inexpensive cost of a medicine produced in Russia.
High prices for concentrates of foreign production. The price is affected by the volume. So, for example, Cisplatin-Teva for cooking 100 ml costs about 800 rubles. The cost of the Austrian drug for injection goes up to 2121 rubles, and the production of Hungary to 1321 rubles.
Analogues
The analogues of cisplatin include drugs such as:
- Aksiplat,
- Blastostem,
- Displanor,
- Crate,
- Oncoplatinum,
- Platamin,
- Platidiam,
- Platymite,
- Platinum,
- Cisanplat,
- Cisplatin.
Synonyms for
Synonyms include Latidiam, Platinol, DDP, DDR, Platilite, Sisplatin.