Allergy creates a lot of unpleasant symptoms for the body, including life-threatening. It is possible to remove signs of the disease with medications with the help of tablets, injections, syrups, etc. The drug that effectively eliminates allergic reactions is Loratadin, about the instructions for use, price, reviews, and analogues of which we'll talk today.
Features of the drug
Loratadin is often in the list of prescription drugs when allergic reactions are detected. The effect of the drug on the body is complex. Reduces the level of histamine in the blood, weakening the manifestation of allergy signs: painful sensations are eliminated, puffiness and itching are eliminated.
The drug does not have the property of reducing effectiveness in the case of long-term use. Refers to antihistamine drugs of the second level( first-generation drugs - Suprastin, Clemastin, etc., are considered less effective in modern pharmacy).Side effect on the state of the nervous system, compared with first-generation drugs, is minimized.
Composition of
Loratadine contains a single substance of the same name, regardless of the form of the drug. The qualitative and quantitative composition of auxiliary substances depends on the form of release of the preparation.
In Loratadine syrup, the excipients are distributed in dosage forms as follows:
- syrup - citric acid powder, cherry( apricot) flavor, 1, 2-propanediol, refined sugar, glycerol, sodium benzoate, purified water;
- tablets - povidone, magnesium stearic, potato( corn) starch, talc, lactose monohydrate, silicon oxide in a colloidal anhydrous state;
- tablets , dissolving in water with evolution of gases - dry citric acid, dry sodium carbonate, macrogol 6000, silicon oxide in colloidal anhydrous state, polysorbate 80, povidone, lactose monohydrate.
Dosage forms
There are 3 varieties of Loratadin on pharmacy shelves:
- Syrup , which has a cherry or apricot flavor with a pleasant specific taste and odor. The color of the syrup can vary in shades from colorless to yellowish or greenish.1 ml of syrup contains 1 mg of active ingredient - loratadine. The syrup is packed in a glass or plastic container and a cardboard box. The package includes instructions, a bottle of plastic( glass) and a measuring spoon.
- Tablets of effervescent round form and yellowish color are packed in blisters of polymer materials and foil of 7( 10) pieces. In the packaging of cardboard from 1 to 3 blisters. The amount of active ingredient in one tablet is 10 mg.
- Round tablets with a transverse band in the middle have a yellowish color. In one tablet of the active substance is the same as in the effervescent tablets. There are bulges on both sides of the tablets.
The minimum price of Loratadin in tablets is 43 rubles per 1 blister with 7 pieces. The same blister of Loratadin effervescent will cost from 132 rubles. The drug syrup approximately costs 170 rubles.
Pharmacological action
Pharmacodynamics
Antiallergic drug has a pronounced long-term effect. The physiological effect after taking the drug is achieved by blocking the histamine receptors - H1.
- Reduces the appearance of itching, the formation of exudate and other allergic reactions.
- A marked spasmolytic effect is observed with respect to smooth muscle fibers.
- The development of edema is not allowed, the possibility of chemical penetration through the single-layered capillary tissue is reduced.
The effect of the drug begins within half an hour, repeated intake is required for the next day.
- Alcohol intake does not affect the physiological effect of Loratadin.
- Prolonged use of the drug does not cause addiction.
- No sedative effect was observed.
Pharmacokinetics
Loratadin is rapidly absorbed in the gastric and intestinal epithelium. After 1 hour and 20 minutes, there is an increased concentration in the blood plasma. After 2 hours and 30 minutes, the maximum concentration of the products of its cleavage is detected in the blood plasma. The half-life of such a drug as Loratadine is 8 hours and 15 minutes.
Metabolized products are cleaved within 1 day 4 hours. Excretion of the drug is through the urinary system. Intermediate decay products are found in urine and human feces.
The blood-brain barrier is insensitive to the action of Loratadine.
The following are the indications for the use of Loratadin.
Indications
Loratadine is prescribed for all types of allergic reactions.
- Actively eliminates allergy signs when mosquito bites, stinging and other insects are bitten.
- Shown with:
- Quincke edema,
- bronchial asthma not infectious genesis,
- allergy to medicines and smoking,
- allergic rhinitis,
- scabies( including nodular)
- dermatitis( including oral, sunlight)
- eczema( including varicose, true, microbial)
- conjunctivitis.
Relieves symptoms after taking analogues of histamine.
Next, instructions will be given on the use of tablets and syrups for Loratadin allergies for children and adults.
Instruction for use
If the doctor has not prolonged the course of treatment for 4 weeks, the usual duration of taking Loratadin is 10 to 15 days.
- Children weighing over 30 kg and adults can take 1 tablet( 10 mg) per day or syrup at the rate of 10 mg of the active ingredient.
- Children with body weight below 30 kg tablets are divided into 2 days or take 5 mg of active ingredient Loratadin per day.
Contraindications
- Loratadine is not prescribed to women during the period of gestation or during breastfeeding.
- requires simultaneous administration of Loratadine with Erythromycin( ketoconazole).
- Loratadine requires careful use with medical supervision for renal and hepatic diseases.
- Severe hepatic pathology prevents the use of Loratadine.
- The drug is withdrawn if, after taking an individual intolerance to its components, it becomes clear.
- A pediatrician in the form of a syrup appoints a dosage for breast children.
Side effects of
Adverse events after taking the drug are associated with a dosing disorder or an individual intolerance to the drug. Within this framework, the following reactions are not excluded:
- from the gastrointestinal tract - diarrhea, constipation, anorexia, nausea and vomiting, hepatic necrosis;
- from the genitourinary system - unpleasant sensations when emptying the bladder, vaginitis, change in the color of urine, menorrhagia;
- from the musculoskeletal system - arthralgia and myalgia, convulsive contraction of the calf muscles, pain in the dorsal muscles;
- from the cardiovascular system - heart palpitations, heart rhythm disturbances;
- from the side of the nervous system - finger tremor, hyperexcitability, alarmism, depression, sleep disturbance, tingling and numbness of hands and feet;
- from the respiratory system - inflammation of the mucous respiratory organs is not an infectious genesis.
Special instructions
The pathologies of the kidneys and liver of medium severity require taking Loratadin 2 times less often.
Interaction with other medicinal substances
The dosage of Loratadine is changed by the attending physician if antibiotics that affect gram-negative bacteria are taken, as these antibacterial agents increase the concentration of Loratadine contained in the blood plasma.
Reviews about tablets Loratadin are given below.
Reviews of Loratadin
Analysis of the reviews of patients taking Loratadine, shows a high evaluation of the effect of the drug. However, most people who take an antihistamine drug are advised to get medical advice beforehand.
Analogues
Among the analogs of Loratadin, 2 groups of analog preparations are distinguished:
- Analogues for the active substance. A total of 8 analogues: Claritin, Erolin, Alerpriv, etc.
- Analogues on the physiological effect( Diazolin, Peritol, Desloratadine, etc.).
Health to you and your family!