Thanks to the choice of drugs with antitumor effect, today it is possible to make the most effective scheme of medicinal and therapeutic effects in the formation of an oncological tumor in the body.
However, among the analogues that have a number of contraindications and possible negative manifestations during admission, one should separately focus on a drug with a pronounced anti-cancer effect of mitotane.
Its excellent performance makes it possible to evaluate the spectrum of action, and ease of use makes it possible to use it even by persons with a high degree of sensitivity to many components.
A state-of-the-art drug, Mitotan, refers to the latest generation of medicines that have been developed with the latest research in the field of cancer treatment and prevention.
The composition of the drug is explained by its high degree of effectiveness, and it is this quality that should be considered fundamental when choosing agents with anti-cancer effect. After all, with the help of mitotane it
becomes possible to reduce both the area of the lesion and reduce the likelihood of rapid spread of the tumor process.
At the same time, the absence of negative influence on healthy tissues allows to preserve their health and reduce the number of negative manifestations when taking the drug.
Form, Composition and Packing
The balance of the formulation affects the degree of its effectiveness. Many doctors noted the excellent ability of its active substance to stop the process of dividing pathologically changed cancer cells, thereby stopping even the started process of the disease course.
The drug is given in the form of white round-shaped pills. The tablets are coated with a film membrane, which dissolves quickly when ingested into the oral cavity.
Tablets are prescribed by a doctor in the treatment of this disease( oncologist), with purchase can be sold in case of prescription.
The norm in the treatment of any type of cancer is prescribed by the doctor, taking into account the individual characteristics of the organism and the sensitivity to the active substance of the drug. The effectiveness of any drug is determined by the content of the active substance in it.
And the composition of the drug Mitotan medics is considered optimal both in terms of the number and mass fraction of the components contained, and in the balance: the auxiliary substances allow to show the medicinal potential of the active component at full capacity.
Mitotan has the following composition:
- The active component is mitotane. When it affects cancer cells, there is a sharp slowdown in their division, stabilization of the patient's condition, and a decrease in soreness.
- Excipients - magnesium stearate, microcrystalline cellulose, crospovidone, povidone.
- The shell consists of the following components: calcium stearate, titanium dioxide, hypromellose, dye.
The listed components form the maximally active substance that perfectly copes with many manifestations of the current pathological process, because it is most often recommended for the treatment of many tumoral diseases.
The drug Mitotan against cancer of the adrenal cortex is on sale in the form of white, convex-shaped tablets that are in a polymer contour blister, each blister contains 10 pieces of the drug tablets.
Blisters are packaged in cardboard. In the carton box there is also an instruction, the presence of instructions allows you to correctly apply this drug.
The package( cardboard) contains the name of the preparation, the country and company of the manufacturer, the active substance content in one tablet and the terms of production and its validity.
The manufacturer of this antitumor agent is HRA Pharma. Also on offer are analogues having a similar pharmacological effect and the same active substance.
Indications for use
Since the preparation of Mitotan has proved itself to be effective in treating various degrees of cancer in the adrenal cortex, it provides the best results in the use of complex-effect methods.
Depression of the main function of the adrenal cortex allows to significantly stop the pathological process of cell division, which facilitates the patient's condition and increases the chances of survival.
To contraindications for the appointment and further use of mitotane, the following conditions of the body and diseases should be attributed:
- kidney damage;
- pathological and inflammatory processes in the liver;
- metabolic disorders( eg, diabetes mellitus);
- acute inflammatory processes in the body;
- Hypersensitivity to the components of the agent;
- susceptibility to allergic reactions;
- kidney failure;
- lesions and failures in the work of the digestive system.
Also to contraindications include the time of breastfeeding, the presence of the last stage of cancer of the digestive tract.
Contraindication can be considered the state of pregnancy, the period of breastfeeding.
Mechanism of action
The use of the drug, according to the opinions of patients and oncologists, is very effective in almost all cases of diagnosing the tumor process in the tissues of the adrenal glands. This is explained by the mechanism of action of the active substance on the altered cells. In this case, the general condition of the patient is improved, the area of the lesion is reduced.
The use of the drug is indicated in the presence of any positive results of treatment.
Instruction for use of mitotane
The use of the drug is simple: the pill should be taken once a day with water. To chew or grind before taking them is not recommended.
However, in particularly severe stages of the disease and with the availability of additional funds to influence the disease, the dose may vary: it is established by the attending oncologist.
At the first stages of the pathological process of developing a cancerous tumor of the adrenal cortex, the following dosage and duration of the drug should be adhered to: during the first 1-2 weeks, the medication is taken once a day in a minimal dosage( 150 mg per day).
In the presence of a positive effect, the same dosage remains with further treatment. In the absence of a pronounced result, the dosage after 2 weeks is increased to 250 mg per day. The duration of such treatment should be at least 3 weeks.
The third stage of adrenal cortex cancer requires a more serious initial dose: during the first week, the doctor usually prescribes a daily dose of 250 mg, which after 1 week increases to 500 mg.
Side effects of
The most frequently reported side effects when using the drug Mitotana in both monoprimony and in complex effects are:
- on the part of the digestive tract may occur such manifestations as belching, bloating and flatulence, vomiting, nausea;
- skin rashes, which are accompanied by itching, redness of the skin and burning;
- increased heart rate activity;
- change in the direction of increasing the heart rate;
- exacerbation of gastritis;
- dysfunction of the gallbladder;
- worsening of liver function, failures in the work of the kidneys with exacerbations.
Nasal bleeding may also occur with this medication. For particularly severe forms of the disease and individual intolerance to the drug, its use should be abolished with the replacement of a similar medication.
In cases of overdose, it is required to urgently clean the intestines and stomach, take the emetic. In case of an overdose, all symptoms characteristic of food or drug poisoning are noted.
The age limit is also less than 18 years, pregnancy. At this time, the sensitivity of the body to individual components of the drug increases, resulting in the appearance of allergic manifestations in the treatment with the drug in question.
Elderly age also requires increased attention during admission, as the body loses some of its protective functions, becoming more susceptible to many of the aggressive components of the drug.
The drug can be used in complex therapy with antitumor agents to enhance therapeutic effect. However, with funds that have arsenic in their composition, Mitotan should not be appointed: the probability of occurrence of side effects is high.
Most patients respond positively to the effectiveness of the drug. The possibility of obtaining a positive result with oncological lesions of the adrenal cortex, the possibility of using in complex therapy made the drug Mitotan the most popular in this case.
Prices for Mitotan drug
Today at the pharmacies of Mitotan is sold at a price of 65 000 rubles per package.
Currently no drugs with the same action and the same active substance are on sale. Therefore, in the selection of individual treatment requires agreement with the doctor.
Lysodren( Lysodren) and Chloditan( Chloditan) are synonyms for the agent in question.
Conditions for dispensing from pharmacies
The drug is dispensed in pharmacies only if there is a prescription from the doctor.
Storage conditions and expiration date
Storage of the preparation requires certain conditions, which allows maintaining a high degree of efficiency in the treatment. Store the drug is recommended in a dark room, with a low moisture content at low temperature changes. It is necessary to protect it from children.