Salofalk is a non-steroidal anti-inflammatory drug. As an active ingredient in colitis, mesalazine acts, suppressing the activity of neutrophilic lipoxygenase, as well as the beginning of the formation of arachidonic acid metabolite, which are a proinflammatory mediator. It can inhibit the secretion of lymphocytes by immunoglobulins, and also affects the migration, phagocytosis and degranulation of neutrophilic granulocytes. Presence of antioxidant effects in colitis.
Salofalk in colitis, depending on how the use method was applied, will be released in the colon cavity and in the terminal section of the small intestine. It can also be released into the cavity of the rectum and colon.
Salofalk is used in case of detection of Crohn's disease and colitis of ulcerative form. Produced in several forms: tablets, granules, suppository and enema. To choose the place of administration of the drug, the duration of the affected intestinal tract and the localization of pathological processes are determined. In combing the treatment of colitis, Salofalk is mainly given in the form of tablets or granules. In the case of proctitis or proctosigmoiditis, rectal administration is recommended as an enema or suppository. Adults are prescribed 500 mg 3 times a day for an hour before meals. As preventive manipulation in colitis, Salofalk can be used in a daily dose of 1500 mg.
Suppositories in case of acute form of the disease are introduced into the rectal cavity at 500 mg 3 times a day. In very pronounced form, the dosage is doubled. In the event that there is a long-term treatment, it is recommended to use 250 mg 3 times a day. The period of therapy is 8-12 weeks.
The enema slurry is applied at a dosage of 60 g 1 time per day at bedtime after preliminary intestinal cleaning.
Before Salofalk is prescribed for colitis, and after 2 weeks of admission, the doctor will be assigned to conduct a clinical blood test and a general urine test. The same survey program is conducted 4 weeks later several times. If good control results are shown, the survey is conducted once every 3 months. Periodically, a determination of the concentration of creatine and urea in blood serum is required. The urinary sediment is also examined. Use Salofalk in colitis need with extreme caution to those who have lung diseases with a violation of their functionality.