Nimesil is a powerful anesthetic that helps with dental, muscular, articular pain, which reduces soreness with dislocations, sprains. Simultaneous reception with alcohol enhances the side effects of Nimesil, causes disturbances in the digestive tract.
Nimesil - properties of
The Nimesil preparation is available in the form of granules with orange, lemon flavor for the preparation of a solution for oral administration. The product is packaged in packets of 1 g containing the active substance nimesulide and auxiliary components.
Pharmacological properties of
Nimesil belongs to the non-steroidal anti-inflammatory agents of the sulfonamide group. The drug inhibits the action of cyclooxygenase 2 - the enzyme responsible for the synthesis of prostaglandins, which trigger inflammatory processes.
The properties of nimesulide include the ability to block enzymes phosphodiesterase, metalloproteinase, involved in the activation of phagocytes - cells of the immune system. These properties allow the use of drugs based on nimesulide for the treatment of joint diseases - osteoarthritis, gouty, rheumatoid arthritis.
Contraindications
Contraindications to taking Nimesil are as follows:
- liver disease;
- diseases of the digestive tract - stomach ulcer, colitis;
- kidney failure;
- diseases of the hematopoiesis;
- heart disease;
- alcoholism;
- age to 12 years;
- pregnancy.
Side effects of
Negative effects of Nimesil on the body most often manifested by the digestive tract. The patient develops an upset stomach, there is vomiting. Less common gastritis, gastric, intestinal bleeding. In extremely rare cases, there is perforation of the stomach.
Less frequently, Nimesil intake affects the cardiovascular, respiratory system, causing:
- tachycardia - increased heart rate;
- sharp changes in blood pressure;
- shortness of breath;
- bronchospasm.
Changes in the nervous system are manifested by dizziness, nervousness, fear, nightmarish dreams, encephalopathy.
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Compatibility with alcohol
Nimesil catalyzes the destructive effect of acetaldehyde on the liver, causes granuloma, leads to acute hepatitis, cirrhosis of the liver.
The main destructive effect of co-administration of the drug and ethanol is manifested by interference in the operation of the stomach. Alcohol provokes irritation of the mucous membrane, gastritis, ulcer.
A dangerous condition that threatens life, arises from the stomach and intestines - internal bleeding when perforating the walls of the organs of the digestive tract. Assume internal bleeding can be in tarry black feces, high ESR.
Influence on Reproductive Health
The uncontrolled use of drugs containing nimesulide is negatively affected by female fertility.
Suppressing the synthesis of prostaglandins, Nimesil:
- disrupts the process of ovulation, prevents the rupture of the wall of the follicle;
- makes it impossible to implant a fertilized egg into the uterus;
- leads to postpartum complications, disruption of the function of the fallopian tubes.
The drug inhibits the synthesis of prostaglandins, causing the fetus to close the arterial duct, which closes normally in the first day after birth. Early closure of the duct leads to the development of congenital heart disease in the child.
Effect on the circulatory system
The drug affects the water-salt balance, causing fluid retention. The same property is also observed in ethyl alcohol. Such a dangerous combination causes swelling, raises blood pressure, disrupts the heart - affects the rhythm, the frequency of myocardial contractions.
One of the side effects of Nimesil is the tides. This action has on the body the presence in the blood of acetaldehyde - a metabolite of ethyl alcohol, causing reddening of the face, a feeling of heat, hot flashes.
By suppressing the synthesis of prostaglandins, nimesulide raises blood pressure. Drinking alcohol also leads to hypertension. With a joint admission, this combination threatens the development of hypertensive crisis, stroke.
Possible consequences
Alcohol intake increases the side effects of Nimesil. Treatment with Nimesil already poses some risk for the woman's reproductive health. Simultaneous reception with a medicine of alcohol-containing beverages can cause the most unpredictable consequences.
And not always the changes caused by the drug are visible. Much more dangerous changes at the level of internal organs, organ systems. The most frequent consequence of taking Nimesil and alcohol is bleeding from the intestine, stomach.
Prostaglandins serve as stimulants for the synthesis of mucus in the stomach. Nimesil blocks the synthesis of prostaglandins, thereby reducing the secretion of mucus in the stomach. This increases the influence of alcohol on the walls of the stomach, increases the risk of ulcers, bleeding.
Rules for taking
How much can I take after ethanol and vice versa? Alcohol can be drunk after taking Nimesil in 6 hours - the half-life of the drug from the body. Nimesil can be treated only after alcohol and the products of its decay leave the body.
Can Nimesil drink with alcohol?
The action of Nimesil is characterized by a number of side effects, similar to the effect on the body of ethyl alcohol and its metabolites. The combination of this drug strengthens each other, retaining the fluid in the body, increasing the pressure.
Doctors say that you can take Nimesil only for the intended purpose, you can not use the drug as an anesthetic, uncontrollably.