A drug that can stop the growth of a malignant tumor or even initiate a decrease in its size is called carboplatin. In clinical practice it has been used since 2004.
Composition, form of production and storage conditions
The active substance is carboplatin. It is a chemical compound that is a derivative of platinum.
The temperature regime at which the drug should be stored: 20 ÷ 80. The storage location should be darkened.
Manufacturer
Produces the drug ZAO Biocad, the country - Russia;company Aktavis, country Italy;a factory located in the US, as well as in Australia.
Indications for use
The agent is prescribed for such diseases:
- non-small cell lung cancer,
- oncology of the uterus,
- ovarian cancer,
- small cell lung cancer,
- melanoma,
- malignant mammary gland formation,
- germ cell tumors in both sexes,
- soft tissue damagesarcoma,
- , oncological disease of the bladder.
Contraindications
The agent should not be taken if there is one or more of the following problems:
- marked myelosuppression is a violation when the bone marrow starts to produce blood cells in a reduced amount;
- if the patient has a negative reaction to the active substance,
- kidneys have severe impairment of function,
- in the body shows bleeding.
Mechanism of action
The active substance of the drug has an alkylating effect, which means that the DNA of the tumor cell is affected by the addition of some derivative of the substance to it. This phenomenon has a destructive effect on the ability of the pathological cell to reproduce.
This action on the body is also called platinization of the immune system and is associated with the fact that platinum, which is part of the product, affects the defenses of the body.
The preparation, in addition to the described alkylating action, still has the following effect:
- cytostatic - inhibits cell division;
- antitumor,
- immunosuppressive.
Instructions for use: dosage of carboplatin
The drug is administered intravenously. In order to determine the dose that will be useful for a particular patient, take into account:
- which treatment scheme is chosen,
- which stage of the tumor process is determined,
- according to the reaction of the body to the received help, an adjustment can be made.
When prescribing the amount of the drug for the course of treatment, the same is taken into account:
- in case of kidney problems - creatinine clearance,
- if a decreased bone formation is observed, then the dose is reduced by ¼.
Side effect of
The use of the product can cause disturbances in the body.
This:
- respiratory problems:
- bronchospasm,
- cough;
- negative changes in the functioning of the digestive system:
- abdominal pain,
- disorders in liver function,
- taste change,
- bleeding of the digestive organs,
- nausea,
- significant weight loss;
- from the heart and vascular system:
- cerebrovascular disorders,
- leukopenia,
- anemia,
- myelodepression,
- hypotension,
- thrombocytopenia,
- bleeding,
- neutropenia,
- heart failure;
- skin problems:
- allergic rashes,
- alopecia;
- malfunctions in the processes responsible for the metabolism;changes in the amount:
- total bilirubin,
- urea,
- creatinine clearance,
- level of AST,
- concentration of sodium in blood plasma,
- too calcium,
- too potassium,
- too magnesium;
- the genitourinary system can get malfunctioning:
- obstructed urination,
- functional disorders in kidney function,
- azoospermia,
- hematuria;
- possible problems related to the sensory and nervous system:
- asthenia,
- hearing loss,
- convulsive syndrome.
Overdose of
If this occurs, this can cause:
- hepatotoxicity,
- nausea,
- bone marrow depression,
- bleeding.
To remove the effects of overdose treatment in a hospital:
- vital functions are checked,
- specialist, if there is evidence, then recommends the procedure for blood transfusions( components);
- is prescribed symptomatic therapy,
- antibiotics can be used.
Special instructions
Treatment with the use of the drug is carried out only according to the purpose of the specialist and under his close supervision. Follow:
- for changes in blood,
- for kidney function,
- for the nervous system.
After the radiotherapy, the drug can be used, but care should be taken.
If the patient has been ill or has infectious diseases, including herpes zoster, chickenpox, then during the course the specialist pays him special attention.
Do not vaccinate patients who are on treatment with carboplatin.
Interaction
For the introduction of carboplatin, do not use tools where the needle is aluminum. If this condition is not met, then when the medicinal solution comes into contact with the metal, a black precipitate is released.
Carboplatin interacts well with vindesine and etoposide. And as a whole the preparation should not be combined for complex treatment.
Patient Reviews
Patients who underwent a course of treatment with carboplatin note that the agent has an effective effect. Particularly noticeable positive results were obtained by patients suffering from ovarian cancer.
There are cases when side effects complicate the general condition. The consequences were removed by symptomatic therapy.
Price in Moscow
The bottle with concentrate, capacity of 45 ml, has an average cost of 2050 rubles.
Carboplatin analogs
This:
- exurum,
- eloxatin,
- platicide,
- oxter,
- displanor.
Synonyms for
This is:
- para-platinum,
- carboplatinium,
- blastocarb,
- cyclopatin,
- para.
- kemokarb;