Antibacterial drug Amoxicillin in an ulcer is prescribed due to the confirmed property of the drug to provide an effective bactericidal action in an acidic environment. Antibiotic refers to the pharmacological group of penicillins, which actively destroy the integrity of the cellular structures of pathogenic microorganisms. The spectrum of sensitive bacteria to the antibiotic is very wide.
Antibiotic Amoxicillin with gastric ulcer disrupts the supporting protein of cellular systems precisely during the period of growth and division, thereby ensuring the inhibition of microorganisms. When administered orally in the form of tablets with a dosage of 500 mg, quickly and stably absorbed in conditions of increased acidity of the digestive organ. Eating does not affect the ability of penetration and concentration in the mucous epithelium.
Parenteral drug administration, that is, bypassing the gastrointestinal tract, is possible with complications of peptic ulcer. In this case, the maximum concentration in the blood plasma and distribution in the tissues of the body occurs within 60 minutes, in principle, as with oral capsules. The active substance easily overcomes the histohematological obstructions between blood and tissue, and accumulates in the contents of erosive defects of the intestinal mucosa. The therapeutic effect lasts for 7-8 hours.
Features of the use of Amoxicillin for ulcer
During clinical trials, data were obtained that Amoxicillin in peptic ulcer effectively kills the main cause of the pathology of the intestinal mucosa - Helicobacter pylori, in combination with an additional antibacterial drug. Most often in the treatment plan include the antibiotic Clarithromycin or Metronidazole. Such measures are necessary to prevent the development of microbe resistance to the drug. The H. Pillory microorganism can immediately adapt to a single-antibiotic therapy regimen.
Usually, an increased dosage of Amoxicillin is prescribed for ulcers - this is 500 mg 3 times a day. A special point of eradication therapy is the combination of Amoxicillin and Omeprazole in order to neutralize excess hydrochloric acid, which prevents scarring of mucosal epithelial defects. Healing of the inflamed coat can not occur with increased acidity.
Now a very convenient dispersible form of the drug appeared on the pharmacological market - Amoxicillin solutab. Tablets dissolve in the mouth under the influence of saliva, which provides undeniable advantages in the convenience of use and high bioavailability of the drug.