Basiron AS: instructions for use, price, reviews, analogs, composition

Baziron AS is a pharmaceutical gel texture product for the treatment of dermatological pathologies in the form of acne, comedones( kind of cystic nodes in the area of ​​hair bulbs formed from sebum and necrotic epidermal cells) and acne. Latin name Basiron AC.

Features of the drug

Medicinal forms

The French company Laboratoires Galderma and the Swiss subsidiary Galderma S.A.produces a medicine in the form of a white gel with a homogeneous structure for external use with a concentration of therapeutic ingredient 2.5, 5.0, 10.0%.

In pharmacies the product comes in polyethylene tubes with a volume of 40 grams, packed in a pack of cardboard, which contains an instruction for use.

Baziron AS( photos before and after application)

Composition Basiron AS AS92PD Active gel is benzoyl peroxide( Benzoyli peroxydum) or benzoyl peroxide.
The amount of active ingredient in 100 grams of the drug is 2.5 grams, 5 or 10 grams according to the percentage of 2.5, 5 or 10%.

Additional gel ingredients: glycerin, dioctyl sodium sulfosuccinate, water, acrylate copolymer, disodium edetate, propylene glycol, carbomer 940, sodium hydroxide, poloxamer 182, anhydrous colloidal silicon.

Price

Estimated cost of Baziron AC depending on the region varies from 699 to 830 rubles with any percentage of Benzoyli peroxydum.

Basiron AS as a preparation, as well as instructions for its use are considered in this video:

Pharmacological action

Pharmacodynamics

The therapeutic ingredient Benzoyli peroxydum is characterized by pronounced antimicrobial action aimed at suppressing the activity of microorganisms causing the process of suppuration in the area of ​​hair bulbs. These include anaerobic Propionibacterium acnes, which produce fatty butyric acid, and epidermal staphylococcus aureus( Staphylococcus epidermidis).And pathogens are not able to produce species that have resistance to the action of benzoyl peroxide.

Therapeutic properties of the drug:

  1. Reduces inflammation and erythema( redness).Studies confirmed that the growth and activity of Propionibacterium acnes after a week of using the gel fell sharply( by 94%), by 14 - 15 days - by 96 - 99%.
  2. Improves nutrition and oxygenation of skin cells.
  3. Suppresses the activity of sebaceous glands and sebum( sebum), reducing the nutrient medium for the bacterium Propionibacterium acne that consumes fatty acids.
  4. It shows keratolytic activity, splitting the horny plates of the epidermis, from which, together with the sebum, acne-forming plugs are formed that clog pores.
  5. Absorbs( absorbs) excess sebaceous secretions.
  6. Dissolves existing comedones, destroying the bacterial film and pulling the sebaceous epithelial plugs from the pores.
  7. The complex of acrylate copolymer and glycerin additionally absorbs excess sebum and moisturizes the epidermis.
  8. Antioxidant properties of benzoyl peroxide provide prevention of tissue aging, beneficially affecting the skin condition.
  9. Eliminates the secondary persistent changes after acne( post-acne) - spots, scars, densities, pigmentation disorders.

Pharmacokinetics

After application of the product on the skin, almost 96% of benzoyl peroxide is transformed into biochemical transformations into an intermediate metabolite - benzoic acid, which after absorption penetrates deep into the epidermis and has a therapeutic effect. Then, through the circulatory system, the metabolite enters the kidneys and is rapidly removed from the body with urine.

There is no evidence of accumulation( accumulation) of the active ingredient in the epidermis and blood flow. This means that the gel has only a local therapeutic effect( on a specific area of ​​the skin) and does not affect the whole organism in any way, if the agent is used in therapeutic doses according to the instructions. That is, there are no system effects from Baziron AC.

Indications

Baziron gel is indicated for the development of the following pathological conditions:

  1. Acne vulgaris( phenomena in the hair follicle zone caused by occlusion of the sebaceous-hair channel), including papulopustular forms( abscesses).Acne and superficial punctual inflammation.
  2. Comedones( closed white and open black).
  3. Trophic ulcers. One of the new properties revealed in the practical use of Baziron in trophic ulcers is activation of blood circulation, nutrition and oxygenation of tissues, which accelerates the healing of the epidermis.

Instruction for Use

Adult

Cleaned from dirt and grease, gently dried skin areas with painful changes are lubricated with a thin layer of gel.
The frequency of using Baziron - 1 or 2 times a day, depending on the severity of the manifestations.

Features

Features:

  1. For single acne and acne, it is optimal to apply the drug point-wise, trying not to affect the clean zones.
  2. Positive changes in the skin are observed already by the 7th - 10th day of therapy, the pronounced effect of the treatment becomes noticeable after 20 - 30 days from the beginning of application of the drug.
  3. The full course of therapy is 12 weeks.
  4. It is undesirable to discontinue Baziron's treatment if improvement occurs earlier, as it is necessary to consolidate the therapeutic effect that occurs by the end of the 3 month therapy.
  5. However, if there is a clear improvement much earlier than the prescribed time, it is allowed to reduce the frequency of application from 2 to 1 times a day or to apply even finer.
  6. With a light and medium course of dermatological pathologies, AC basiron is used as a mono drug( the only agent used).
  7. In severe forms of acne, pustular lesion, the gel is recommended to be applied in combination with other local and general remedies: retinoids, glucocorticosteroids, antibiotics, androandrogens.
  8. . If necessary, an additional course of therapy is performed, but only after appointment by a dermatologist.

Choice of gel concentration

Practical studies show that the effectiveness of the drug is related to the concentration of the therapeutic component. However, to avoid severe irritation or undesirable resistance to the medication, do not start treatment, immediately applying Basiron AC at a concentration of 10 or 5%.

  • For primary use, the optimum percentage of benzoyl peroxide is 2.5%.
  • If necessary, a 5% gel can be applied.
  • The pharmacological product with a higher concentration( 10%) should be used:
    • with severe skin manifestations that do not eliminate the use of a gel with a therapeutic substance content of 5 and 2.5%.
    • if there are no positive changes at a lower dosage.

For children and newborns

Basiron AC is not used under any conditions for treatment of children under 12 years, especially - breast and newborn.

In pregnancy and lactation

No special studies have been conducted on external topical use of benzoyl peroxide in women bearing fetuses. Therefore, there is no confirmed medical information about the effects of Baziron on the embryo and fetus, the course of labor and the degree of teratogenicity( development of embryonic deformities).
To avoid unexpected reactions, the gel is not used during pregnancy.

There is no clinical experience on the isolation of benzoyl peroxide with human milk, so a sufficiently high risk for babies can not be ruled out. To prevent the ingestion of the active substance in the baby's mouth during breastfeeding, the mother should not use the gel to apply to the mammary glands.

Contraindications

Basiron AC is not used:

  • with special individual intolerance of any ingredients in the composition of the pharmaceutical product;
  • in children and adolescents younger than 12 years;
  • in pregnant women.

In this video, the girl Katya will talk about her experience using Basiron AS:

Side effects of

In most patients, adverse reactions from the gel, which are used according to the indications and in the recommended dosages, are either mildly expressed or absent.

  • In 1 - 3 patients out of 10 there is dryness, redness, peeling, burning of the skin.
  • In 2 to 4 patients receiving local treatment with Baziron, itching, tingling, soreness on the gel application areas, contact dermatitis may develop.
  • Very rarely there is an allergic reaction in the form of allergic dermatitis( less than 2 to 3 cases out of 1000).

All unpleasant reactions found during treatment are reversible and are usually eliminated or reduced with the coloring frequency of the gel application. With the withdrawal of therapy, they completely disappear.

Special instructions

  • At the first application of the gel, the patient sometimes has a feeling of slight tingling, burning, redness, and peeling of the skin for 3 to 5 days. These phenomena, if they are weak, are not dangerous and, as a rule, disappear in a few days or for 1 to 3 days with a temporary withdrawal of treatment.
  • If severe skin irritation is observed, immediately stop using the drug until the discomfort disappears. Then try to apply again, reducing the number of applications per day or concentration. If unwanted reactions are resumed, the use of the gel is completely stopped.
  • Excessive application of the gel with a thick layer does not lead to a faster or more pronounced therapeutic result, but causes a strong overdrying of the epidermis, irritation and accelerated addiction.

In the course of treatment, the following features are taken into account by Basiron:

  1. The gel is not applied to areas with erosion, damages, wounding.
  2. If the product enters the mouth, nose, eyes, mucous membranes, rinse well with warm water.
  3. During treatment, active sunlight is avoided on gel-treated areas to avoid hyperpigmentation and irritation, since benzoyl peroxide increases the sensitivity of the epidermis to ultraviolet light. Devices with high protection from the sun, visors, darkened large glasses are desirable.
  4. During the treatment period, do not use products containing alcohol and drying the skin.
  5. It should be noted that touching the hair with colored hair and materials can lead to a change in color.

Interaction with other drugs

There is no information on the interaction of the gel with other medications for local and general use.

Reviews

Most of the patients receiving external treatment with Baziron AC, positively assess the properties of the gel, noting that the pharmacological product really saved them from acne and acne. In the reviews, various periods are mentioned, under which there was a clear improvement, which is due to the severity of the process and the presence of internal provocative diseases and to whether all recommendations on the use of the product were observed.

Among the shortcomings are the irritation of the epidermis after the application of the gel, the drying of the skin and the need for a sufficiently long course for a sustainable effect. In some cases, Baziron gives a very pronounced and rapid improvement, but some deny any positive effect at all.

Dermatologists explain that the absence of a noticeable therapeutic result can be the result of an illiterate use of the drug. For example, patients use the product as a mono drug against a background of serious hormonal disorders, severe infection, pustular infection. And with a complicated acne process, it is necessary that the gel is used only in combination with other drugs. It can be retinoids, hormones, antibiotics for local or systemic use, which will eliminate the causative factor of skin changes. But these funds are assigned by a specialized specialist, based on the survey data.

Analogues of

Analogues of

Among analogs of Baziron AC, that is, preparations with a similar therapeutic effect, but not necessarily with a similar active ingredient, dermatologists distinguish:

  • Epiduo,
  • Zinerite,
  • Bezacne,
  • Differin,
  • Desquam,
  • Benzoyl peroxide,
  • Skinoren.

This video is an overview of the Baziron SS:

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