Such a drug is developed in the form of ointments and rectal suppositories in proctology. And in this article, we'll talk about the instructions for using Bufexamak, its analogs, the price and feedback of doctors and patients about it.
Features of the preparation
This drug is successfully used in both proctology and dermatology. About this and talk.
Composition of Bufexamak
- Composition of rectal suppositories is saturated with active substances( bufexamak 0.25 g, titanium oxide TiO2 0.1 g, bismuth salt gallic acid 0.1 g, lidocaine hydrochloride monohydrate 0.01 g) andauxiliary substances for the desired consistency of candles and better absorption of basic substances( wax, solid fat, isopropyl palmitic acid ester).
- 20 g ointments Bufexamac contain 1 g of bismuth salt of gallic acid, 1 g of bupexamac, lidocaine hydrochloride - 100 mg, titanium oxide - 1 g. As auxiliary substances, polycos, water, palmitic acid isopropyl ester, liquid paraffin, wax, additive E491( SPEN 60), which is a sorbitol ester of stearic acid, are used.
Dosage Forms
A medicinal preparation is known in the form of two forms: ointments under the trademark Proctosan, produced by Germany and the rectal suppositories of Proctosan.
- Candles can be bought in Russian pharmacies at a price of 230-260 rubles per package with 10 suppositories.
- Ointment, which is a package with an applicator and a 20-gram tube, costs about 280 rubles.
Pharmacological action
Farmakodinamika
Bufeksamak, being a derivative of acrylic acid, is included in the category of non-steroidal anti-inflammatory drugs. Inflammatory processes with external and rectal use of Bufexamak terminate under the action of blocking the activity of substances that are the cause of the development of inflammatory reactions - mediators of inflammation. Mediators trigger chain reactions in violation of the selective permeability of cell membranes, metabolic processes in cells and tissues, and the functioning of organs.
The task of bufexamak, as a non-steroidal anti-inflammatory drug, is to inhibit the secretion of the cyclooxygenase enzyme responsible for the synthesis of the main mediator of inflammation, arachidonic acid, in the tissues. After inhibition of the production of arachidonic acid, inhibition of the synthesis of prostaglandins is initiated.
Pharmacokinetics
No data are available on intermediates, maximum concentration and period of exposure. The half-life of the compound is about 5 hours.
The indications for use of Bufexamak are given below.
Indications
As an external agent, Bufexamak is used in the treatment of neurodermatitis and eczema of chronic form. Also, Bufexamak is used in the treatment of hives, cold, warm. In the progress of diseases, substitutes for the new generation of glucocorticosteroids( non-halogenated forms) are used. Their preference is due to the lack of a thinning effect on the epidermis and dermis of the skin.
The result of treatment with these drugs is an approach to the remission stage, which is supported by balneotherapy, selective phototherapy and the use of non-steroidal anti-inflammatory drugs such as Bufexamaka. In dermatological practice, Bufexamac has limited use only in those areas of skin eczema that are adjacent to the anus. Indications for use of the preparation are cracks on the surface of the anal opening.
Most cases of use of Bufexamak is associated with hemorrhoids in stages 1 and 2 of the degree of progress. Good progress in treatment is achieved with inflammatory processes in the rectum( proctitis, etc.).
Instruction for use
- Before using suppositories and Bufexamak ointment, the affected area of the surface is washed with warm water using a baby soap. The number of procedures with applying Bufexamak ointment - 2 times. When hemorrhoids ointment is used twice a day, injecting it with the help of an applicator into the ampoule of the rectum deeply.
- The course of treatment usually lasts for 10 days, unless the doctor appoints a different period and periodicity. With incomplete disappearance of symptoms, two courses of treatment without an interval are not excluded. Rectal suppositories are administered after a preliminary act of defecation.
Contraindications to the use of Bufexamak are given below.
Contraindications
- Due to the high absorption of Bufexamak into the blood and easy penetration through the hematoplacental, hemato-milk and blood-brain barrier, the period of fruiting and lactation in women creates an obstacle for its use in this category of patients.
- The drug is not used and with individual intolerance to the components of a non-steroidal anti-inflammatory drug.
- For children until adolescence, the drug is replaced with analogues with a softer effect on the skin.
- There are a number of contraindications for specific inflammations in proctology and dermatology with lesion localization near the anus.
Side effects of
If the patient does not have any cases of allergic reactions to the components of the drug, adverse reactions to suppositories and Bufexamak ointment are not noticed. Allergic reactions may be accompanied by reddening of the area after application of the drug, as well as mild itching and burning, the formation of acne and vesicles.
Special instructions
Bufexamak is not used in the acute phase of the disease. To this end, treatment is reduced to hormonal therapy( the intake of glucocorticoids that remove inflammatory processes).After eliminating inflammation, treatment with non-steroidal anti-inflammatory drugs( Proctosan, Bufexamac, etc.) is allowed.
Interaction with other drugs
There is no data on the drug interaction of Bufexamak with other drugs.
Reviews
No negative feedback is given regarding the effectiveness of the drug in the pathologies indicated in the indications. There is information about the rapid relief of the symptoms of diseases after the application of Proctosan and Bufexamak. The scheme of the drug and the absence of adverse reactions are indicated by all users who have left comments on the forums.
Some users attribute the high costs to the shortcomings of the use of the remedy, which is explained by the low level of income of these users( retirement age).A cosmetic drawback of the remedy is the smearing of underwear after the use of rectal suppositories and ointments. Traces in the toilet bowl with plain cold water are not completely washed away.
Analogues
In addition to Bufexamak, as a non-steroidal anti-inflammatory drug, ointment and rectal suppositories of Proctosan are used in indications.